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Myelosafe Capsule

Prescription Required
SALT COMPOSITION

Overview

Introduction

Myelosafe Capsule is used in the treatment of multiple myeloma and lepra reaction. This medicine belongs to a group of medicines which affect how your immune system works.

Myelosafe Capsule can be taken with or without food, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

Some common side effects of this medicine include headache, weakness, nausea, rash, and dizziness. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections or bleeding. Hence, take caution while performing the activity that might increase your chances of bleeding or avoid contact with people suffering from infection such as cold. Regular blood tests are required to check your blood cells while on treatment.

Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. You are advised to drink plenty of fluids to stay hydrated while taking this medicine.

Uses of Myelosafe Capsule

Side effects of Myelosafe Capsule

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Myelosafe

  • Headache
  • Weakness
  • Nausea
  • Rash
  • Dizziness
  • Sleepiness
  • Edema (swelling)
  • Loss of appetite
  • Decreased white blood cell count
  • Decreased calcium level in blood
  • Weight gain
  • Muscle weakness
  • Fatigue
  • Fever
  • Anxiety
  • Blood clots
  • Dry skin
  • Weight loss
  • Confusion
  • Decreased white blood cell count (neutrophils)
  • Neuropathy
  • Constipation
  • Tremor

How to cope with side effects?

The occurrence of side effects varies from person to person. The following are a few ways of dealing with some of the common side effects. However, consult your doctor if these persist.

  • Coping with Headache
    Make sure you rest and drink plenty of fluids. Rest in a quiet, dimly lit room. Do not sleep more than you normally would. Do not strain your eyes (for example by looking at a screen). Do not drink alcohol. Headaches are usually temporary and usually go away with time. But, if they last longer or get worse, ask your doctor to recommend a painkiller.
  • Coping with Weakness
    Make sure you rest and drink plenty of fluids. Eat a well-balanced diet to keep your energy levels up. Do not drink too much alcohol. Do not drive or use tools or machinery until you feel better. Other things that can help include doing some gentle exercise every day, prioritizing and pacing your activities and having a short nap if you need to. If you are still having problems after a week, speak to your doctor, as they may want to change you to a different type of medicine.
  • Coping with Nausea
    You can help yourself by eating small, frequent meals rather than large ones and drinking plenty of fluids. Eat slowly. Avoid fatty, fried, spicy and very sweet foods. Eat cold or slightly warm food if the smell of cooked or cooking food makes you feel sick. Get plenty of fresh air. You could also try chewing ginger or drinking ginger tea. Eat bananas to replace potassium in your blood which can drop if you are sick (vomit). Use oral rehydration salts to replace vitamins and minerals lost through being sick. There are some medicines that can help you stop from feeling sick. Speak to your doctor if your condition does not improve.
  • Coping with Rash
    There are many treatments for a wide range of skin problems. Avoid hot showers or baths because hot water can irritate the skin. Make sure to pat dry your skin after a bath or shower. Do not rub or scratch the affected area. Leave the skin exposed to the air as much as possible. Do not use perfumed soaps or deodorants. Water containing chlorine can make most skin problems worse, so avoid swimming. Avoid spicy foods, alcohol, tobacco smoke and caffeine as it may also make itching worse. Avoid excessive sun exposure. Always use sunscreen and protective clothing when outdoors. Moisturizers can be used regularly to soothe and hydrate the affected area. If it does not get better within a week, speak to a pharmacist or doctor.
  • Coping with Dizziness
    This is usually short-lived and should go away within a few days. If this happens, stop what you are doing and sit or lie down until you feel better. Lying still in a dark, quiet room may help reduce the spinning feeling. Sleep with your head slightly raised on two or more pillows. Get up slowly from a lying or sitting position. Get plenty of rest and try to relax as being anxious can make it worse. Try taking this medicine at bedtime to reduce the symptoms. Drinking plenty of water and ginger tea may also help. Avoid alcohol, caffeine and smoking as it will make you feel worse. Avoid driving or using tools or machinery until you feel better.
  • Coping with Sleepiness
    If the medicine is making you drowsy during the day, stop what you are doing and sit or lie down until you feel better. You can also consider taking a nap. Physical exercises such as walking may be helpful. Do not drink alcohol, as it will make you feel more tired. Avoid driving or operating heavy equipment when you are feeling drowsy. This problem usually goes away as your body gets used to the medicine. However, if it does not, ask your doctor if you can take your medicine at bedtime or whether the dose can be reduced.
  • Coping with Loss of appetite
    It is important to eat, even if you do not feel like it. You might try switching to smaller meals and frequent snacks. Try eating healthy and nutritious snacks that are high in calories and protein, such as dried fruit and nuts. It is important to drink even if you cannot eat. But, do not fill your stomach with liquid before eating. Eat when you are most hungry. Exercise such as a short walk may also increase your appetite. Talk to your doctor about possible medication or supplements if your condition does not improve.
  • Coping with Decreased white blood cell count and Decreased white blood cell count (neutrophils)
    If you have a low level of white blood cells, you are more likely to get infections. There are several ways to reduce your chances of catching or spreading an infection. Avoid unnecessary exposure to germs when you can. Wash your hands frequently and thoroughly with soap or use a sanitiser. Avoid crowds and avoid contact with people who are ill or have infections. Use disposable tissues for coughs and sneezes. Consider using an appropriate face mask. Do not share personal items like cutlery, glasses, towels or toothbrushes with others. Get enough rest and eat a well balanced healthy diet.
  • Coping with Weight gain
    Try to eat a healthy balanced diet without increasing your portion sizes. Avoid processed meat or poultry and seafood. Eat small, frequent meals and eat slowly. Do not snack on foods that contain a lot of calories such as crisps, cakes, biscuits and sweets. If you feel hungry between meals, eat fruits and vegetables which have low calories. Avoid reaching for a sugary drink if you feel stressed. Fasting once a week can be an effective way to lose weight. Make sure you get enough sleep. With proper diet and lifestyle changes, you might not gain any weight or may gain only a small amount. Even then if it bothers you, ask your doctor if there are any alternative medicines that do not have this side effect.
  • Coping with Muscle weakness
    Tell your doctor straight away because sometimes the muscle pain may be a sign of something more serious. A lower dosage or a different medication might be needed. Try to relax the cramping muscle by stretching it and holding the stretch. You might massage the muscle or apply a heat pad to the area after stretching. Avoid exercising too much. Stay well-hydrated. Do not take over-the-counter pain relievers unless the doctor prescribes it. Your doctor may also suggest taking supplements, such as calcium, magnesium oxide or potassium oxide depending on your needs.
  • Coping with Anxiety
    This often disappears when the condition you are being treated for is managed. You could ask your doctor about changing the dose of your medicine or alternatives if it is affecting your daily life or causing you distress. Psychological treatments may be available. Some things you can do to help yourself include stopping smoking, cutting down the amount of alcohol and caffeine you drink, and doing regular exercise. You should also eat a healthy diet and find out how to get sleep if you are having trouble. Try talking to a friend or family member. Calming breathing exercises and other relaxation techniques may also help.
  • Coping with Dry skin
    Use mild cleansing creams or soaps rather than harsh or perfumed ones. Use warm water (not hot) and do not spend too long in the bath or shower. Long bathing hours or using harsh soaps can wash away natural oils. Dry your skin gently with a towel and apply moisturizer immediately after washing. Do not use alcohol-based products on your skin. Choose clothing fabrics that will not irritate your skin.
  • Coping with Weight loss
    As a general rule, speak to your doctor if you lose weight while using this medicine. Losing too much weight can lead to malnutrition. Increase the amount of food you eat. Try eating foods that are high in calories and protein. Drink warm milk instead of tea every so often. Eat smaller meals and eat more often. There may be medicines and physical activities that can improve your condition.Speak to your doctor about this.
  • Coping with Confusion
    If this medicine makes you feel this way, stop what you are doing and sit or lie down until you feel better. If the feeling does not go away or troubles you, do not take any more medicine and speak to a pharmacist or your doctor.
  • Coping with Constipation
    Try to eat foods which are high in fiber such as fresh fruits, vegetables and cereals to increase the bulk and consistency of bowel movements. Drink plenty of water or non-alcoholic drinks and stay hydrated to promote healthy digestion. Increasing physical activities such as walking, yoga and regular exercise can also be helpful. If your condition does not improve, you can ask your doctor to prescribe you laxative medicine.
  • Coping with Tremor
    These symptoms can be a sign that the dose is too high for you. It may help to change your dose or take your medicine at a different time of the day. There are also exercises that can improve muscle strength, control and coordination. In terms of lifestyle, avoid caffeine (in coffee, tea and chocolate), alcohol, and ask your doctor about other techniques to help you relax and manage stress. Talk to your doctor if this bothers you. Your doctor may be able to prescribe you medicines that can help.

How to use Myelosafe Capsule

Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Myelosafe Capsule may be taken with or without food, but it is better to take it at a fixed time.

How Myelosafe Capsule works

Myelosafe Capsule is an anti-cancer medication. It works by enhancing the immune system that indirectly attacks the cancer cells. It prevents the growth of new blood vessels within the tumor. It also restricts the production of chemical messengers (cytokine and growth factor) which are responsible for the growth of cancer cells. This is how it works against cancer.

Safety Advice

Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Myelosafe Capsule. Please consult your doctor.
Pregnancy
UNSAFE
Myelosafe Capsule is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
Breastfeeding
CONSULT YOUR DOCTOR
Myelosafe Capsule is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
UNSAFE
Myelosafe Capsule may cause side effects which could affect your ability to drive.
You may feel dizzy, tired, sleepy, have vertigo or blurred vision after taking Myelosafe Capsule and this may affect your ability to drive.
Kidney
CAUTION
Myelosafe Capsule should be used with caution in patients with kidney disease. Dose adjustment of Myelosafe Capsule may be needed. Please consult your doctor.
Liver
CAUTION
Myelosafe Capsule should be used with caution in patients with liver disease. Dose adjustment of Myelosafe Capsule may be needed. Please consult your doctor.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
No alternate brands found for this medicine

Quick Tips

  • You may be monitored with regular blood tests before and during the treatment as lenalidomide may cause a fall in the white blood cells and platelets, required to fight infection, Hemoglobin and blood clotting.
  • Avoid activities that may cause bruising or injury and avoid contact with people who have colds or infections.
  • It makes your skin sensitive towards sunlight. Apply sunscreen or wear protective while going out. 
  • It may cause dehydration. Drink plenty of water to stay hydrated while taking medication.
  •  It is not recommended for use in children and adolescents under 18 years.
  • You should use proper contraceptive methods at least 4 weeks before, during and until 4 weeks after stopping treatment. 
  • Woman of childbearing potential will be required to undergo pregnancy tests before and after the treatment.
  • You should inform your doctor or dentist that you are taking Myelosafe Capsule before you receive any medical or dental care, emergency care, or surgery.
  • It may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
  • You may be at risk of developing acute myelogenous leukemia, Hodgkin lymphoma tumor lysis syndrome, fatal liver problems, severe skin reactions, and fatal heart problems during treatment with Myelosafe Capsule. You should discuss in advance the benefits and risks of taking this medicine. 

Patient Concerns

arrow
Please tell me the interpretation of the attach report, if possible. Also guide for further treatment process.
Dr. Sanjay Singh Rai
Medical Oncology and Hematology
U r having multiple myeloma
Multiple myeloma can be cured or not
Dr. Rohan Khandelwal
Surgical Oncology
Yes, if diagnosed at the right stage
arrow
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FAQs

Q. Can I take Myelosafe empty stomach?

Myelosafe may be taken with or without food. Always take it exactly as prescribed by your doctor. Do not crush, cut or chew the capsules. Swallow it whole with water. You should take Myelosafe at about the same time on the scheduled days.

Q. Can Myelosafe be given to patients who are on dialysis?

Yes, Myelosafe is given to dialysis patients after the dialysis is done. However, the doctor may adjust the dose if needed in patients undergoing.

Q. What are the side effects of Myelosafe?

Myelosafe may cause side effects which include diarrhea, constipation, stomach pain, loss of appetite, weight loss, weakness, dizziness, change in ability to taste, and pain or burning of the tongue, mouth, or throat. The medicine may also cause decreased sense of touch, burning or tingling in the hands or feet, difficulty falling asleep or staying asleep, depression, and joint, muscle, bone, or back pain. You may also experience sweating, dry skin, abnormal hair growth in women, uncontrollable shaking of a part of the body, decrease in sexual desire or ability or painful, frequent, or urgent urination. Tell your doctor if any of these symptoms are severe or do not go away.

Q. What are the serious side effects of Myelosafe?

The serious side effects of Myelosafe include difficult breathing or swallowing, hoarseness or swelling of the face, throat, tongue, lips, eyes, arms, hands, feet, ankles, or lower legs. Some of the serious side effects may also include seizures, rash, skin pain, fast, slow, pounding, or irregular heartbeat or blistering, peeling, or shedding skin. It may also cause swollen glands in the neck, muscle cramps, pain in the upper right part of the stomach, yellowing of the skin or eyes, dark colored urine, tiredness, or bloody, cloudy, or painful urination and increased or decreased urination. Call your doctor immediately if you get any of these side effects.

Q. Can Myelosafe cause cancer?

People with multiple myeloma (a form of cancer that begins in plasma cells, a type of white blood cell) who receive melphalan (chemotherapy) and a blood stem cell transplant with the addition of Myelosafe have a higher risk of developing new cancers. These types of cancers may include certain blood cancers (acute myelogenous leukemia or AML) and a type of lymphoma called Hodgkin lymphoma. Talk to your doctor about your risk of developing new cancers if you are taking Myelosafe.

Q. Do I need to get any blood tests done while on Myelosafe?

Your doctor will ask you to have a blood test before treatment and every week for the first 8 weeks of treatment. You may need to continue taking the blood tests at least every month after treatment with Myelosafe ends. Frequent blood tests are important as Myelosafe may decrease the blood cells that help fight infection (white blood cells) and help the blood to clot (platelets).

Q. Do I need to use birth control methods while using Myelosafe?

Women who can become pregnant must use two acceptable forms of birth control for 4 weeks before they begin taking Myelosafe. Continue using contraceptives during your treatment, including the times when your doctor tells you to temporarily stop taking Myelosafe, and for 4 weeks after your final dose. In men, Myelosafe may pass into the semen while they are on treatment. Therefore, men must always use a latex condom every time they have sexual contact, even if they have had a vasectomy (surgery that prevents a man from causing a pregnancy). Use the contraceptive while you are taking Myelosafe, during any breaks in your treatment, and for 4 weeks after your final dose.

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Disclaimer:

1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Chabner BA, Barnes J, Neal J, et al. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1742.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 784-85.
  3. Lenalidomide. Summit, New Jersey: Celgene Corporation. [Accessed 26 Mar. 2019] (online) Available from:External Link
  4. Central Drugs Standard Control Organisation (CDSCO). [Accessed 26 Mar. 2019] (online) Available from:External Link

Manufacturer/Marketer Address

NO.21, V CROSS,VENKATESA NAGAR EAST, PONDICHERRY 605008 605008 PY 605008 IN , - , .
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