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Mitobulin Solution for Injection

Written By Dr. Sakshi Jain, MS, BDS
Reviewed By Dr. Rajeev Sharma, MBA, MBBS
Last updated on 07 Apr 2026 | 03:01 PM (IST)
Mitobulin Solution for Injection is used in the treatment of breast cancer. It is used to treat adults with breast cancer that has spread to other parts of the body, and who have already received other anticancer medicines after the cancer has spread.
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General Information

Contains

Eribulin Mesylate (0.5mg/ml)

Marketer

Cipla Ltd

Storage

Store below 30°C
The content is shown in English
Mitobulin Solution for Injection image
Mitobulin Solution for Injection image

Product introduction

Mitobulin Solution for Injection can be used on its own, or sometimes given together with certain other medicines as part of combination chemotherapy. It is given as injection under the supervision of doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine include weakness, hair loss, nausea, and constipation. This medicine may reduce the number of blood cells (decrease red blood) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid and electrolytes levels. You might experience numbness, tingling or pricking sensations in your hands and feet. Consult with your doctor immediately if it bothers you or would not go away on their own.

Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Mitobulin Solution for Injection

  • Treatment of Metastatic breast cancer

Benefits of Mitobulin Solution for Injection

Treatment of Metastatic breast cancer
Mitobulin Solution for Injection helps to treat breast cancer and it may be used alone or in combination with other medicines or treatment modalities like chemotherapy. This medicine is used when other medicines have not shown significant improvement and the cancer has spread to other parts as well. It relieves the symptoms of breast cancer such as breast lumps, bloody discharge from nipples or changes in the shape or texture of the breast. Mitobulin Solution for Injection kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. Discuss with your doctor if any of the side effects bother you.

Side effects of Mitobulin Solution for Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Mitobulin
  • Anemia (low number of red blood cells)
  • Weakness
  • Hair loss
  • Nausea
  • Constipation
  • Decreased white blood cell count
  • Fatigue
  • Peripheral neuropathy (tingling and numbness of feet and hand)

How to use Mitobulin Solution for Injection

Your doctor or nurse will guide you how to use this medicine.

How Mitobulin Solution for Injection works

Mitobulin Solution for Injection is an anticancer medication. It works by interfering with the microtubule structures which help the cancer cells to divide and multiply. This blocks the growth cycle (cell cycle) of cancer cells and eventually kills them.

Quick tips

  • Mitobulin Solution for Injection helps treat breast cancer that has spread to other areas of the body.
  • It is given by an injection into a vein (intravenously).
  • It may cause dizziness and tiredness. Do not drive or do anything requiring concentration until you know how it affects you.
  • Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine and for three months after you stop taking it.
  • Your doctor may get regular blood tests done to monitor your blood cells and electrolyte levels during treatment with this medicine.
  • Inform your doctor immediately if you notice any signs of infection such as fever, sore throat, rash or severe diarrhea while taking this medicine.
  • It may cause numbness, tingling or pricking sensations in your hands and feet. Inform your doctor if this bothers you.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Mitobulin Solution for Injection. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Mitobulin Solution for Injection is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding

Breast feeding

UNSAFE
Mitobulin Solution for Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving

Driving

UNSAFE
Mitobulin Solution for Injection may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

CAUTION
Mitobulin Solution for Injection should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Liver

Liver

CAUTION
Mitobulin Solution for Injection should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Mitobulin with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Severe

Isoflurane (Inhalation Route)

Your doctor may regularly monitor your blood potassium levels and ECG during the simultaneous use of these medicines.
Severe

Mizolastine (Oral Route)

Do not consume Mizolastine with Eribulin Mesylate.
Severe

Ribociclib (Oral Route)

Concurrent use should be avoided. Please consult with your doctor.
Severe

Arsenic Trioxide (Injection Route)

Concurrent use should be avoided. Please consult with your doctor.
Severe

Amiodarone (Oral Route)

Concomitant use may affect heart rhythm and may be fatal.

Frequently asked questions

Hair loss is a common side effect of Mitobulin Solution for Injection. It could be reversible but the severity of hair loss varies from person to person. Consult your doctor if you have any concerns regarding hair loss.
Mitobulin Solution for Injection is usually given on Days 1 and 8 of each recommended 21-day cycle. The duration of treatment varies from person to person. The number of cycles required for effective treatment will be decided by your doctor. Depending on the results of your blood tests, the doctor may need to delay administration of the medicine until the blood tests return to normal. If required, the doctor may also decide to reduce the dose you are given.
Mitobulin Solution for Injection will be given to you by a doctor or healthcare professional as an injection into a vein, over a period of 2 to 5 minutes. The dose required will be decided based on your body surface area (expressed in square metres, or m2) which is calculated from your weight and height. The doctor may adjust the usual dose based on your blood test results or other factors. To ensure that the whole dose of Mitobulin Solution for Injection is given, it is recommended that a saline solution is flushed into the vein after Mitobulin Solution for Injection is given.
Mitobulin Solution for Injection can cause serious side effects which include low white blood cell count (neutropenia). This can lead to serious infections that could lead to death. It can also cause numbness, tingling, or pain in your hands or feet (peripheral neuropathy). Peripheral neuropathy is common with Mitobulin Solution for Injection and sometimes can be severe. It can cause harm to the baby when administered to a pregnant woman.
Women of childbearing age should use effective contraception during and up to 3 months after treatment with Mitobulin Solution for Injection.It may cause serious birth defects and should not be used if you are pregnant unless it is thought clearly necessary after carefully considering all the risk to you and the baby.
Mitobulin Solution for Injection should be handled carefully. Avoid any contact with skin, eyes, mouth and insides of nose. It is recommended to use gloves, goggles, and protective clothing while handling the medicine. If the skin comes into contact with the solution, it should be washed immediately and thoroughly with soap and water. Similarly, if your eyes, mouth or nose come in contact with Mitobulin Solution for Injection, flush the area thoroughly with water. Pregnant staff should not handle Mitobulin Solution for Injection.
Mitobulin Solution for Injection may be diluted in up to 100 ml of sodium chloride 9 mg/ml (0.9%) solution and not in 5% dextrose. It should be given under the supervision of a physician experienced in giving cancer chemotherapy and should be administered by a health care professional only.

Fact Box

Chemical Class

Halichondrins

Habit Forming

No

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Antimicrotubule agents- Non Taxanes

References

  1. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 489.
  2. Central Drugs Standard Control Organisation (CDSCO). [Accessed 27 Mar. 2019] (online) Available from:
  3. Eribulin Mesylate. Frankfurt am Main Germany: Eisai GmbH; 17 Mar. 2011 [revised Jan. 2019]. [Accessed 27 Mar. 2019] (online) Available from:
  4. Cancer Research Uk. Eribulin Mesylate. [Accessed 27 Mar. 2019] (online) Available from:
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Cipla Ltd
Address: Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013

Vendor Details

Country of origin: India

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