Metadoxil Injection

Metadoxine (300mg)

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Metadoxil Injection is an antioxidant medicine used to treat alcoholic fatty liver. It works by protecting the liver from harmful chemical substances and also increases the alcohol elimination from blood and tissues.

Written By Dr. Anuj Saini, MMST, MBBS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 13 Jan 2026 | 09:26 PM (IST)

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General Information

Contains

Metadoxine (300mg)

Marketer

Micro Labs Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Metadoxil Injection should be given by the healthcare professional. The dose will depend on what you are being treated for and your body weight. This medicine needs to be taken regularly to get the most benefit and you may have to take it for several months or longer, so try to get into a routine. Keep using it as prescribed even if your symptoms disappear.

The most common side effects are nausea, upset stomach, and diarrhea. Not everyone gets side effects. If you are worried about them, or they do not go away, let your doctor know. If you have problems with diarrhea your doctor may reduce the dose or stop the treatment. Drink enough water or fluids to stay hydrated in case of severe diarrhea.

Before taking this medicine, you should tell your doctor if you are pregnant, planning pregnancy or breastfeeding. Using this medicine can reduce or increase the effect of some other medicines so tell your doctor, all other medicines you are taking.

Uses of Metadoxil Injection

Alcoholic fatty liver disease

Benefits of Metadoxil Injection

Alcoholic fatty liver disease
Metadoxil Injection belongs to a class of drugs known as hepatoprotectives. It fastens clearance of alcohol from the blood and therefore helps in the treatment of fatty liver due to alcoholism. In the long term, it protects the liver from damage against harmful chemicals known as free radicals, thereby improving the overall health of the liver.

It is given as an injection by your doctor or healthcare provider. Take it in the dose and duration advised by the doctor. To make the medicine more effective and for general health benefits, stop smoking, maintain a healthy weight, and do not drink too much alcohol.

Side effects of Metadoxil Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Metadoxil

Nausea
Upset stomach
Diarrhea

How to use Metadoxil Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Metadoxil Injection works

Metadoxil Injection is an antioxidant. It works by protecting the liver from harmful chemical substances (free radicals). It also works by increasing alcohol elimination from the blood and tissues, thus preventing liver damage.

Quick tips

It protects the liver cells from toxins and helps the liver to perform its normal functions.
It is given as an injection under the supervision of a healthcare professional.
Diarrhea may occur as a side effect. Drink plenty of fluids and inform your doctor if diarrhea persists or if you find blood in your stools.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Metadoxil Injection. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Metadoxil Injection during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Metadoxil Injection during breastfeeding is not available. Please consult your doctor.

Driving

CONSULT YOUR DOCTOR

It is not known whether Metadoxil Injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.

Kidney

CONSULT YOUR DOCTOR

There is limited data available on the use of Metadoxil Injection in patients with kidney disease. Please consult your doctor.

Liver

CONSULT YOUR DOCTOR

There is limited data available on the use of Metadoxil Injection in patients with liver disease.

Interaction with drugs

Taking Metadoxil with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Altretamine (Oral Route)

Do not consume Altretamine with Metadoxine. Metadoxine may reduce the efficacy of Altretamine.

Moderate

Phenytoin (Oral Route)

Talk to your doctor if you notice any unusual symptoms.Doctor may monitor your liver function. Metadoxine may raise blood levels of Phenytoin.

Moderate

Phenytoin (Injection Route)

Talk to your doctor if you notice any unusual symptoms.Doctor may monitor your liver function. Metadoxine may raise blood levels of Phenytoin.

Moderate

Levodopa (Oral Route)

Talk to your doctor if you notice any unusual symptoms. Metadoxine may slow down the removal of Levodopa from the body.

Mild

Nitrofurantoin (Oral Route)

Talk to your doctor if you notice any unusual symptoms. Metadoxine may reduce blood levels of Nitrofurantoin.

Frequently asked questions

What is Metadoxil Injection? What is it used for?

Metadoxil Injection belongs to a class of medicines known as hepatoprotective medicines which means that they protect the liver. It is used to treat chronic and acute alcohol intoxication. Metadoxil Injection accelerates alcohol clearance from the blood and therefore, also helps in the treatment of fatty liver due to alcoholism.

How does Metadoxil Injection work?

Metadoxil Injection works by increasing the rate of alcohol clearance from blood and tissues, which leads to faster recovery from alcohol intoxication. This in long term protects the liver from damage against harmful chemicals known as free radicals, thereby improving overall health of the liver.

How to use Metadoxil Injection?

Metadoxil Injection is given by or under the supervision of a healthcare professional. It should not be self administered. The dose will depend on the condition you are being treated for and your total body weight. Hence it may vary from person to person. Follow your doctor’s instructions carefully to get maximum benefit of Metadoxil Injection.

What are the side effects of Metadoxil Injection?

The most common side effects associated with Metadoxil Injection include nausea, upset stomach and diarrhea. However, these effects are not observed in all patients. If you are worried about them or they do not go away, let your doctor know. If you have problems with diarrhea your doctor may reduce the dose or stop the treatment. Drink enough water or fluids to stay hydrated in case of severe diarrhea.

Can Metadoxil Injection be used in pregnancy and lactation?

Metadoxil Injection is not advised to be taken by pregnant and breastfeeding women. Consult your doctor before taking Metadoxil Injection if you are planning to conceive, pregnant or breastfeeding to prevent harmful effects on the baby.

Fact Box

Chemical Class

Pyridoxine derivative

Habit Forming

Therapeutic Class

NEURO CNS

Action Class

Hepatoprotective Agents

Related lab tests

Bilirubin Total

Liver Function Test

References

Stefanini GF, Addolorato G, Caputo F, et al. Treatment of alcoholic fatty liver: is the metabolic effect of metadoxine the only reason for improved liver function? J Hepatol. 1999 Apr;30(4):739-40. [Accessed 13 Jan. 2026]. Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Micro Labs Ltd
Address: 27, RACE COURSE ROAD, BANGALORE-560 001, INDIA

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Metadoxil Injection

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Metadoxil Injection

Benefits of Metadoxil Injection

Side effects of Metadoxil Injection

How to use Metadoxil Injection

How Metadoxil Injection works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Altretamine (Oral Route)

Phenytoin (Oral Route)

Phenytoin (Injection Route)

Levodopa (Oral Route)

Nitrofurantoin (Oral Route)

Frequently asked questions

What is Metadoxil Injection? What is it used for?

How does Metadoxil Injection work?

How to use Metadoxil Injection?

What are the side effects of Metadoxil Injection?

Can Metadoxil Injection be used in pregnancy and lactation?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Bilirubin Total

Liver Function Test

References

User feedback

What are you using Metadoxil Injection for?

How much was the improvement?

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

Related/Popular tests