Melitus 2.5mg/400mg Tablet


Overview

Uses of Melitus Tablet
Melitus 2.5mg/400mg Tablet is used in the treatment of type 2 diabetes.
Melitus Tablet side effects
Common
  • Hypoglycemia (low blood sugar level)
  • Taste change
  • Nausea
  • Diarrhoea
  • Stomach pain
  • Headache
  • Upper respiratory tract infection
How to use Melitus Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Melitus 2.5mg/400mg Tablet is to be taken with food.
This medicine may cause stomach upset if taken empty stomach.
How Melitus Tablet works
Melitus 2.5mg/400mg Tablet is a combination of two antidiabetic medicines: Glibenclamide and Metformin. Glibenclamide is a sulfonylurea which works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Metformin is a biguanide which works by lowering glucose production in the liver, delaying glucose absorption from intestines and increasing the body's sensitivity to insulin.
Melitus Tablet related warnings
Alcohol
CAUTION
Taking metformin with alcohol can cause lactic acidosis and you may experience malaise, respiratory distress, slow or irregular heartbeat, sleepiness, stomach upset, or other unusual symptoms.
Pregnancy
PROBABLY SAFE
Melitus 2.5mg/400mg Tablet is probably safe to use during pregnancy.
Animal studies have shown low or no adverse effect on the foetus, however, there are limited human studies. Please consult your doctor.
Lactation
Melitus 2.5mg/400mg Tablet is probably safe to use during lactation. Limited human data suggests that the drug does not represent a significant risk to the baby.
Driving
Your ability to drive may be affected if your blood sugar is low or high. If this happens, do not drive.
Kidney
UNSAFE
Melitus 2.5mg/400mg Tablet is probably unsafe to use in patients with kidney disease and should be avoided. Please consult your doctor.
Liver
CAUTION
Melitus 2.5mg/400mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Melitus 2.5mg/400mg Tablet may be needed. Please consult your doctor.
Melitus 2.5mg/400mg Tablet is generally started with low dose in patients with mild to moderate liver disease and its use is not recommended in patients with severe liver disease.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
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Expert Advice

  • You have been prescribed this combination medicine as it can control blood sugar better than metformin alone.
  • You should continue to exercise regularly, eat a healthy diet, and take your other diabetes medicines along with Melitus 2.5mg/400mg Tablet.
  • Take it with food to lower your chance of having an upset stomach.
  • Monitor your blood sugar level regularly while you are taking this medicine. 
  • Inform your doctor about your diabetes treatment if you are due to have surgery under a general anaesthetic.
  • It can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal. 
  • Tell your doctor immediately if you experience any deep or rapid breathing or if you have persistent nausea, vomiting, and stomach pain as Melitus 2.5mg/400mg Tablet may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood.
  • Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).

Patient Concerns

Questions Related to Melitus

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He is my father who has been suffering from diabetes and now he is unable to walk freely due to burning of feet & leg pain. Attending Dr. said that nerves of the feet has been damaged. The prescriptions & reports are not available with me right now. But I can send it's soft copy later.
Dr. Sanjay Bhatt
Diabetes Specialist
it is happening because of diabetes melitus Continue medicine ad priscribed by doctor. Try to keep blood sugar level in normal limits
High cholesterol and lipid. Also type 2 diabetes under control. Vegetarian. Pls advise on dite
Dr. Waseem Mirza
Sexologist
Per day calorie intake should be between 1,500-1,800 calories with a proportion of 60:20:20 between carbohydrates, fats and proteins, respectively, take Healthy fats from raw nuts, olive oil, fish oils, flax seeds etc, fresh Fruits and vegetables,whole grains, legumes and other high-fibre diet, avoid refined carbohydrate diet,if u eat non veg u can take fish, poultry egg white, pulses whereas avoid red meat, avoid saturated fats like ghee, butter, avoid sweet foods, take small but frequent meals, supplements containing omega 3 fatty acids like Multivite fm omega capsule Quit smoking, avoid too much alcohol intake, find ways to reduce stress like meditation, yoga, etc. Moderate exercise daily like a brisk walk for 1 km. hope it helps
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FAQs

Q. What is Melitus?
Melitus is a combination of two medicines: Glibenclamide and Metformin. This medicine is used in the treatment of type 2 diabetes mellitus (DM) along with diet and exercise to improve blood glucose levels in adults. Glibenclamide lowers the blood glucose levels by increasing the release of insulin from the pancreas. Metformin works by lowering the glucose production in the liver and improving insulin sensitivity. This combination is not indicated for the treatment of Type 1 DM.
Q. What is type 2 diabetes?
Type-2 diabetes, which is the most common form is a condition when the body is not able to make enough insulin, and the insulin produced by the body does not work well. When this happens, the level of glucose rises in the blood that leads to serious medical problems. Symptoms of high blood sugar include frequent urination, increased thirst, and increased hunger. Diabetes, if not treated properly, can cause long-term complications like neuropathy (nerve damage), nephropathy (kidney damage), eye damage (retinopathy), foot problems and also develop higher risk of heart diseases.
Q. What are the possible side effects of Melitus?
The use of Melitus is associated with common side effects like hypoglycemia (low blood sugar level), altered taste, nausea, stomach pain, diarrhea, headache and upper respiratory tract infection. Its use can also lead to serious, but rare side effects like lactic acidosis. On long-term use, it can also lead to Vitamin B12 deficiency.
Q. Can the use of Melitus cause hypoglycemia?
Yes, the use of Melitus can cause hypoglycemia (low blood sugar level). Symptoms of hypoglycemia include nausea, headache, irritability, hunger, sweating, dizziness, fast heart rate and feeling anxious or shaky. It happens more often if you miss or delay your food, drink alcohol, do more than routine exercise or take other antidiabetic medicine along with. So, regular monitoring of blood sugar level is important. Always keep a quick source of sugar like glucose tablets, honey or fruit juice with you.
Q. Can the use of Melitus cause lactic acidosis?
Yes, the use of Glipenclamide+Metformin can lead to lactic acidosis. It is a medical emergency which is caused by increased levels of lactic acid in the blood. It is also known as MALA (Metformin associated lactic acidosis). It is a rare side effect associated with the use of metformin and therefore, it is contraindicated in patients with underlying kidney disease, old age patients or who take large amounts of alcohol. Symptoms of lactic acidosis may include muscle pain or weakness, dizziness, tiredness, feeling of cold in arms and legs, difficulty in breathing, nausea, vomiting, stomach pain or slow heart rate. If you have these symptoms, stop taking Glipizide+Metformin and immediately consult your doctor
Q. Can the use of Melitus lead to Vitamin B12 deficiency?
Yes, the use of Melitus can cause vitamin B12 deficiency on long-term use as it interferes with absorption of vitamin B12 in the stomach. If untreated, it may cause anemia and nerve problems and the patient can have tingling sensation and numbness in hands and feet, weakness, urinary problems, change in mental status and difficulty in making balance (ataxia). To avoid such problems, some researchers suggest an intake of vitamin B12 from outside at least once every year.
Q. Are there any specific conditions in which Melitus should not to be taken?
The use of Melitus should be avoided in patients with known allergy to any of the component or excipients of this medicine, in patients with moderate to severe kidney disease and in patients with underlying metabolic acidosis including diabetic ketoacidosis.
Q. Is it safe to take alcohol while I am also taking Melitus?
No, it is not safe to take Melitus along with alcohol, as it may lower your low blood sugar levels (hypoglycemia) and can increase the chances of lactic acidosis.
Q. What are the instructions for storage and disposal of Melitus?
Keep this medicine in the container or pack it came in, tightly closed. Store it as mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children, and other people.
Information last updated by Dr. Varun Gupta, MD Pharmacology on 6th Sep 2018.
The medicine details are for information purpose only. Consult a doctor before taking any medicine.
Manufacturer/Marketer Address
16th Floor, Godrej BKC, Plot – C, “G” Block, Bandra-Kurla Complex, Bandra (East), Mumbai – 400 051, India
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MRP
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10 tablets in 1 strip
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