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    Glibenclamide + Metformin

    Information about Glibenclamide + Metformin

    Glibenclamide + metformin uses

    Glibenclamide+Metformin is used in the treatment of type 2 diabetes mellitus.

    How glibenclamide + metformin works

    This is a combination of two antidiabetic medicines: Glibenclamide and Metformin. Glibenclamide is a sulfonylurea which works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Metformin is a biguanide which works by lowering glucose production in the liver, delaying glucose absorption from intestines and increasing the body's sensitivity to insulin.

    Common side effects of glibenclamide + metformin

    Hypoglycemia (low blood sugar level), Taste change, Nausea, Diarrhea, Stomach pain, Headache, Upper respiratory tract infection
    Content Details
    Written By
    Dr. Betina Chandolia
    MDS, BDS
    Reviewed By
    Dr. Ashish Ranjan
    MD (Pharmacology), MBBS
    Last updated on:
    27 Sep 2019 | 11:32 AM (IST)
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    Read Our Editorial Policy

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    Expert advice for Glibenclamide + Metformin

    • Take it with food to lower your chance of having an upset stomach.
    • You should continue to exercise regularly, eat a healthy diet, and take your other diabetes medicines along with Glibenclamide + Metformin.
    • It can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal. 
    • Inform your doctor about your diabetes treatment if you are due to have surgery under a general anesthetic.
    • Tell your doctor immediately if you experience any deep or rapid breathing or if you have persistent nausea, vomiting, and stomach pain as Glibenclamide + Metformin may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood.
    • Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).

    Frequently asked questions for Glibenclamide + Metformin

    Glibenclamide + Metformin

    Q. What is Glibenclamide+Metformin?

    Glibenclamide+Metformin is a combination of two medicines: Glibenclamide and Metformin. This medicine is used in the treatment of type 2 diabetes mellitus (DM). It improves the blood glucose levels in adults when taken along with proper diet and regular exercise. Glibenclamide lowers the blood glucose levels by increasing the release of insulin from the pancreas. Metformin works by lowering the glucose production in the liver and improving insulin sensitivity. This combination is not indicated for the treatment of Type 1 DM.

    Q. What is type 2 diabetes?

    Type 2 diabetes is the most common form of diabetes. It is a condition in which the body is unable to make enough insulin, and the insulin produced by the body does not work well. When this happens, the glucose level in the blood rises and leads to serious medical problems. Symptoms of high blood sugar include frequent urination, increased thirst and increased hunger. Diabetes, if not treated properly, can cause long-term complications like neuropathy (nerve damage), nephropathy (kidney damage), eye damage (retinopathy), foot problems and also a higher risk of developing heart diseases.

    Q. What are the possible side effects of Glibenclamide+Metformin?

    The use of Glibenclamide+Metformin is associated with common side effects like hypoglycemia (low blood sugar level), altered taste, nausea, stomach pain, diarrhea, headache and upper respiratory tract infection. Its use can also lead to serious but rare side effects like lactic acidosis. On long-term use, it can also lead to vitamin B12 deficiency.

    Q. Can the use of Glibenclamide+Metformin cause hypoglycemia?

    Yes, the use of Glibenclamide+Metformin can cause hypoglycemia (low blood sugar level). Symptoms of hypoglycemia include nausea, headache, irritability, hunger, sweating, dizziness, fast heart rate and feeling anxious or shaky. It happens more often if you miss or delay your food, drink alcohol, over-exercise or take other antidiabetic medicine along with this medicine. So, regular monitoring of blood sugar level is important. Always keep a quick source of sugar like glucose tablets, honey or fruit juice with you.

    Q. Can the use of Glibenclamide+Metformin lead to Vitamin B12 deficiency?

    Yes, the use of Glibenclamide+Metformin can cause vitamin B12 deficiency on long-term use as it interferes with the absorption of vitamin B12 in the stomach. If untreated, it may cause anemia and nerve problems and the patient may feel a tingling sensation and numbness in hands and feet, weakness, urinary problems, change in mental status and difficulty in maintaining balance (ataxia). To avoid such problems, some researchers suggest an intake of Vitamin B12 from outside sources at least once every year.

    Q. Are there any specific conditions in which Glibenclamide+Metformin should not to be taken?

    The use of Glibenclamide+Metformin should be avoided in patients with known allergy to any of the components or excipients of this medicine. It should also be avoided in patients with moderate to severe kidney disease and in patients with underlying metabolic acidosis including diabetic ketoacidosis.

    Q. Is it safe to take alcohol while I am also taking Glibenclamide+Metformin?

    No, it is not safe to take Glibenclamide+Metformin along with alcohol, as it may lower your low blood sugar levels (hypoglycemia) and can increase the chances of lactic acidosis.

    Q. What are the instructions for storage and disposal of Glibenclamide+Metformin?

    Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

    Content on this page was last updated on 27 September, 2019, by Dr. Varun Gupta (MD Pharmacology)