MACOX PLUS 150MG TABLET
Macleods Pharmaceuticals Pvt Ltd
Composition for MACOX PLUS 150MG TABLET
Prescription RequiredPrimarily used for
Tuberculosis (Tb), leprosy
Potentiallyunsafewith
Alcohol
Pregnancy
₹12.6
₹2.1/tablet
6 tablets in 1 strip
1 Strip
Substitutes for MACOX PLUS 150MG TABLET
FAMINEX KID 150 MG/100 MG TABLET
Lark Laboratories Ltd
₹1.88/tablet
save 11%
Medicine Overview of MACOX PLUS 150MG TABLET
Side effects of Rifampicin
Common
Skin rash, Nausea, Vomiting, Chills, Muscle pain.
How to use Rifampicin
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. It is better to take Macox plus 150mg tablet empty stomach (1 hour before food or 2 hours after food).
Avoid Macox plus 150mg tablet with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.
Avoid Macox plus 150mg tablet with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.
How MACOX PLUS 150MG TABLET works
Rifampicin is an antibiotic. It works by killing the bacteria that cause infections.
Side effects of Isoniazid
Common
Peripheral neuropathy (tingling and numbness of feet and hand), Increased liver enzymes, Hepatitis (viral infection of liver), Jaundice.
How to use Isoniazid
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. It is better to take Macox plus 150mg tablet empty stomach (1 hour before food or 2 hours after food).
Avoid Macox plus 150mg tablet with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.
Avoid Macox plus 150mg tablet with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.
How MACOX PLUS 150MG TABLET works
Isoniazid is an antibiotic. It works by killing the bacteria that causes tuberculosis.
In Depth Information on MACOX PLUS 150MG TABLET
Expert advice for Rifampicin
- Rifampin interacts with many drugs. Please inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects.
- Do consult your doctor before taking rifampin if you wear contact lenses. Using rifampin may permanently stain your contact lenses.
- Taking rifampin may produce a brownish-red coloration of the urine, sweat, sputum and tears. This is not a harmful effect.
- Do consult your doctor before taking rifampin if you are pregnant or planning to become pregnant.
- Do consult your doctor if you are taking oral contraceptive medications for birth control. Your doctor may ask you to use other means of birth control (eg. condom, diaphragm with spermicide) to prevent pregnancy while taking rifampin.
- Do consult your doctor before taking rifampin if you are breast-feeding.
- Do consult your doctor before taking rifampin if you are aged 65 years or above.
- If you take rifampin irregularly or if daily administration is resumed after a drug free interval, you may experience ‘flu syndrome’ (includes episodes of fever, chills, headache, dizziness, and bone pain).
- Rifampin should preferably be taken in the morning before breakfast. Taking rifampin with food is known to delay its absorption (process by which the active drug reaches the affected site in the body via blood circulation) thereby, hampering its effectiveness.
- Do not stop taking rifampin without consulting your doctor.
Expert advice for Isoniazid
- Do not take isoniazid, if you have severe liver problems or if you have taken isoniazid in the past and it caused liver problems, fever, chills, joint pain, or severe allergic reaction.
- Contact your doctor immediately, if you experience symptoms such unusual tiredness (fatigue), weakness, feeling of discomfort (malaise), loss of appetite (anorexia), urge to vomit (nausea) or vomiting while taking isoniazid. It indicates that you are progressing towards liver damage.
- Do consult your doctor before taking isoniazid if you are aged above 35 years. The frequency of isoniazid related inflammation of liver (hepatitis) is higher in individuals older than 35 years of age. The doctor may advice measurement of blood levels of enzyme transferases before starting treatment with isoniazid.
- Avoid drinking alcohol. It may increase your risk of liver damage while you are taking isoniazid.
- Do consult your doctor before taking isoniazid, if you are pregnant or planning to become pregnant or are breastfeeding.
- Isoniazid interacts with many drugs. Please inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects.
- Do not stop taking isoniazid without consulting your doctor.
- If you forget to take a dose of Isoniazid, take it as soon as you remember. Do not double the dose to make up for the missed dose.
Warnings
Special precautions for MACOX PLUS 150MG TABLET
Alcohol
CAUTION
Macox plus 150mg tablet may cause symptoms such as flushing,
+more increased heartbeat, nausea, thirst, chest pain and low blood pressure with alcohol (Disulfiram reactions).
...
Pregnancy
WEIGH RISKS VS BENEFITS
Macox plus 150mg tablet may be unsafe to use during pregnancy.
Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor....
+moreAnimal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
Lactation
SAFE
Macox plus 150mg tablet is probably safe to use during breastfeeding. Please consult your doctor.
Driving
CAUTION
Caution is advised when driving or operating machinery.
Kidney
CAUTION
Caution to be advised in patients with impaired renal function.
Liver
There is no data available. Please consult doctor before consuming the drug.
Patient Concerns
Frequently asked questions for MACOX PLUS 150MG TABLET
Frequently asked questions for Rifampicin
Q. Is rifampin and rifampicin same?
Yes. Rifampin (nomenclature in the United States) and rifampicin (nomenclature in Britain) is the same antibiotic commonly used in the treatment of tuberculosis and leprosy
Q. Is rifampin a penicillin/amoxicillin/sulfa drug?
No. Rifampin is an antibiotic commonly used in the treatment of tuberculosis and leprosy. It has a structure and mechanism of action different from penicillin or amoxicillin (amoxicillin belongs to the class of penicillin antibiotics). The chemical structure and mechanism of action of rifampin is different from sulfa drugs
Q. Is rifampin bacteriostatic or bactericidal?
Rifampin is a bactericidal drug. It acts by blocking the activity of a bacterial enzyme called DNA-dependent RNA polymerase which essential for important life processes in the bacteria, thereby killing the bacteria
Q. Is rifampin an inducer or inhibitor?
Rifampin is an inducer (increases activity) of an important liver enzyme system that is responsible for the final processing and elimination of several drugs from the body
Q. What is R-cin 600 used for?
R-cin 600 is a trade name for active drug rifampin 600 mg. Rifampin is an antibiotic commonly used in the treatment of tuberculosis and leprosy. It is also used in the prevention of meningococcal meningitis and Haemophilus influenza infections. It may also be used in combination with other drugs to treat infections-Brucellosis, Legionnaires disease or serious staphylococcal infections
Q. What is R-cinex/Macox plus/R-cinex 600?
R-cinex and Macox plus are trade names for a combination of active drugs rifampin and isoniazid. It is used in the treatment of tuberculosis. R-cinex 600 and Macox plus contains 600 mg of active drug rifampin and 300 mg of active drug isoniazid
Q. Can I take rifampin with ibuprofen/acetaminophen (Tylenol)?
Rifampin has no known serious drug interaction with ibuprofen or acetaminophen (trade name: Tylenol). Inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects
Q. Does rifampin cause weight gain/weight loss/ hair loss/ constipation/ yeast infection?
No. Changes in body weight, hair loss or triggering constipation are not among the known side effects of rifampin. Rifampin is an antibiotic commonly used in the treatment of tuberculosis and leprosy. It has no known effect on causing yeast infections
Q. Does rifampin cause headaches?
Yes. Headache is a possible side effect of rifampin
Q. Does rifampin change urine color/turn urine orange?
Yes. Taking rifampin may change the color of your urine (skin, sweat, saliva, tears and feces) to brownish-red or orange. This effect is not harmful
Q. Does rifampin cause liver damage?
Rifampin is safe when used at prescribed doses for the prescribed duration. Constant monitoring of liver function is important while on treatment with rifampin. Taking drugs like saquinavir, ritonavir with rifampin can cause severe liver damage. Do consult your doctor if you have any liver problem before taking rifampin.
+more
Frequently asked questions for Isoniazid
Q. Is isoniazid an antibiotic?
Isoniazid is an antibiotic used in the prevention and treatment of tuberculosis or TB (a serious infection caused by bacteria that affects the lungs and in certain cases other parts of the body)
Q. Is isoniazid chemotherapy/chemotherapy drug?
Isoniazid is a primary antibiotic used for treatment of tuberculosis. Do not confuse it with chemotherapy or chemo drugs used for the treatment of cancer
Q. Is isoniazid bacteriostatic or bactericidal?
Isoniazid is a bacteriostatic antibiotic. It stops or suppresses growth of tuberculosis causing bacteria by interfering with the formation of protective outer covering (cell wall) which is essential for their growth
Q. Is isoniazid safe?
Yes. Isoniazid is safe if used at prescribed doses for the prescribed duration as advised by your doctor
Q. Is isoniazid a MAOI?
Isoniazid has very weak inhibitory activity on enzymes monoamine oxidases (MAO); however it is not used as a monoamine oxidase inhibitor (MAOI)
Q. Is isoniazid a sulfa drug?
No. The chemical structure and mechanism of action of isoniazid is different from sulfa drugs
Q. Is isoniazid an inducer or inhibitor?
Isoniazid is an inhibitor (decreases activity) of an important liver enzyme system that is responsible for the final processing and elimination of several drugs from the body
Q. Can I take isoniazid with ibuprofen/Benadryl/Nyquil/Aleve/Mucinex/amoxicillin?
There no known serious drug interactions of isoniazid with ibuprofen, paracetamol (trade name: Tylenol), naproxen (trade name: Aleve), amoxicillin or any active drug present in Nyquil or Mucinex. Please inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects
Q. Does isoniazid cause weight loss/weight gain/hair loss/diarrhea/affect menstruation?
Changes in body weight (gain/loss), hair loss, diarrhea or changes in menstruation are not among the known side effects of isoniazid. You may experience few of these side effects while on multi drug (including isoniazid) treatment for tuberculosis
Q. Does isoniazid cause acne/make you tired/cause constipation?
You may experience unusual tiredness, constipation or acne while on treatment with isoniazid. Please inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects
Q. Does isoniazid affect birth control?
Isoniazid has no known interaction with commonly used oral contraceptives (birth control pills). However, multidrug treatment for tuberculosis contains active drug rifampin that decreases the effectiveness of oral contraceptives and hampers birth control.
+more
