Maclet 5 Tablet
Prescription Required
Product introduction
Maclet 5 Tablet helps treat breast cancer in post-menopausal women. It may be used alone or with other treatments, such as surgery or radiation. It can also be used in patients with advanced breast cancer to stop the tumor from spreading to other parts of the body.
Maclet 5 Tablet is used to treat breast cancer in women who have gone through the menopause.
Uses of Maclet Tablet
Side effects of Maclet Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Maclet
- Night sweats
- Bone pain
- Cough
- Shortness of breath
- Fatigue
- Weight gain
- Hot flushes
- Edema (swelling)
- Flushing (sense of warmth in the face, ears, neck and trunk)
- Diaphoresis
- Bone fracture
- Hypercholesterolemia (high cholesterol)
- Joint pain
- Back pain
- Weakness
- Dizziness
- Nausea
- Osteoporosis
- Joint inflammation
How to use Maclet Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Maclet 5 Tablet may be taken with or without food, but it is better to take it at a fixed time.
How Maclet Tablet works
Maclet 5 Tablet is an aromatase inhibitor. It works by decreasing the amount of estrogen (natural female hormone) produced in the body. This decrease in estrogen can slow down or stop the growth of some breast cancers that need estrogen to grow.
Safety advice
Alcohol
SAFE
Consuming alcohol with Maclet 5 Tablet does not cause any harmful side effects.
Pregnancy
UNSAFE
Maclet 5 Tablet is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
Breast feeding
UNSAFE
Maclet 5 Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving
UNSAFE
Maclet 5 Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney
SAFE IF PRESCRIBED
Maclet 5 Tablet is safe to use in patients with kidney disease. No dose adjustment of Maclet 5 Tablet is recommended.
However, there is limited information on the use of this medicine in patients with end stage kidney disease. Please consult with your doctor.
However, there is limited information on the use of this medicine in patients with end stage kidney disease. Please consult with your doctor.
Liver
CAUTION
Maclet 5 Tablet should be used with caution in patients with liver disease. Dose adjustment of Maclet 5 Tablet may be needed. Please consult your doctor.
What if you forget to take Maclet Tablet?
If you miss a dose of Maclet 5 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.\n
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
Maclet 5 Tablet
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Quick tips
- You have been prescribed Maclet 5 Tablet for the treatment of breast cancer.
- It can be taken with or without food.
- Do not drive or do anything requiring concentration until you know how Maclet 5 Tablet affects you.
- It may cause increased sweating and hot flushes. Try to keep cool by wearing light and airy clothes.
- Your doctor may monitor your cholesterol level and bone mineral density (BMD) regularly as Maclet 5 Tablet can alter their levels.
- Do not take Maclet 5 Tablet if you are pregnant or breastfeeding
Fact Box
Chemical Class
Diphenylmethane Derivative
Habit Forming
No
Therapeutic Class
ANTI NEOPLASTICS
Action Class
Aromatase Inhibitors
Interaction with drugs
Taking Maclet with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Do not consume Letrozole with Allylestrenol if you have or had breast cancer. If essential, consult your doctor.
Allylestrenol may reduce the efficacy of Letrozole.
Do not consume Letrozole with Dehydroepiandrosterone (Micronized) if you have or had breast cancer. If essential, consult your doctor.
Dehydroepiandrosterone (Micronized) may redu
Do not consume Letrozole with Desogestrel if you have or had breast cancer. If essential, consult your doctor.
Desogestrel may reduce the efficacy of Letrozole.
Do not consume Tamoxifen with Letrozole. If concurrent use is essential, please consult your doctor. Tamoxifen may reduce blood levels of Letrozole.
Patient concerns
FAQs
Why have I been prescribed Maclet 5 Tablet?
Maclet 5 Tablet is an aromatase inhibitor. It is generally prescribed to treat breast cancer in women who no longer have periods, either due to menopause or after surgery or chemotherapy.
How does Maclet 5 Tablet work?
Maclet 5 Tablet is also known as an anti-estrogen drug. It is called so because it acts by reducing the production of estrogen in your body by blocking the enzyme aromatase, which is responsible for the production of estrogen. Estrogen stimulates the production of certain types of breast cancer in your body. These cancers are called "estrogen-dependent cancers". Reducing the production of estrogen may prevent cancer from growing.
For how long should I take Maclet 5 Tablet?
If the breast tumor is in the advanced stage or has spread to other parts of the body, it is recommended that you continue taking Maclet 5 Tablet till the tumor shows progression. In cases where Maclet 5 Tablet is given after tamoxifen (another anti-estrogen used for breast cancer) or surgery, it should be given for 5 years or until the tumor comes back, whichever is first. It can also be given as a sequential treatment; 2 years of Maclet 5 Tablet followed by 3 years of tamoxifen.
If I am taking irbesartan to control my blood pressure, can I take Maclet 5 Tablet?
Yes, you can take irbesartan and Maclet 5 Tablet together. However, be careful and keep a regular check on your blood pressure since Maclet 5 Tablet may increase your blood pressure. Consult your doctor in case you have problems controlling your blood pressure.
Does Maclet 5 Tablet affect vision?
Although it is very uncommon, Maclet 5 Tablet may cause a cataract. So, if you experience blurred vision or eye irritation, consult your doctor immediately.
My friend who is taking Maclet 5 Tablet often sweats a lot. Is it because of Maclet 5 Tablet?
This could be a sign of hot flushes which is a very common side effect of Maclet 5 Tablet. It happens due to decreased estrogen levels. The frequency of hot flushes reduces once your body adjusts to Maclet 5 Tablet. However, in some people, the flushes and sweats may continue during the treatment and stop a few months after the treatment finishes. You can consult your doctor who will provide you a remedy if it is very bothersome.
What are the serious side effects of Maclet 5 Tablet?
The serious side effects do not occur in everyone and very few people experience them. The serious side effects of Maclet 5 Tablet include stroke, angina, heart attack, blood clotting, cataract, osteoporosis, and severe skin reactions.
Does Maclet 5 Tablet cause bone loss?
Maclet 5 Tablet may cause thinning or wasting of your bones (osteoporosis), which is due to the decrease in estrogen levels in your body. Your doctor may decide to measure your bone density (a way of monitoring for osteoporosis) before, during and after treatment.
Can I take Maclet 5 Tablet for induction of ovulation in anovulatory infertility?
As per the Ministry of Health and Family Welfare, Maclet 5 Tablet is restricted for use in induction of ovulation in anovulatory infertility.
Why have I been prescribed Maclet 5 Tablet?
Maclet 5 Tablet is an aromatase inhibitor. It is generally prescribed to treat breast cancer in women who no longer have periods, either due to menopause or after surgery or chemotherapy.
How does Maclet 5 Tablet work?
Maclet 5 Tablet is also known as an anti-estrogen drug. It is called so because it acts by reducing the production of estrogen in your body by blocking the enzyme aromatase, which is responsible for production of estrogen. Estrogen stimulates the production of certain types of breast cancer in your body. These cancers are called "estrogen-dependent cancers". Reducing the production of estrogen may prevent the cancer from growing.
For how long should I take Maclet 5 Tablet?
If the breast tumor is in advanced stage or has spread to other parts of the body, it is recommended that you continue taking Maclet 5 Tablet till the tumor shows progression. In cases where Maclet 5 Tablet is given after tamoxifen (another anti-estrogen used for breast cancer) or surgery, it should be given for 5 years or until tumor comes back, whichever is first. It can also be given as a sequential treatment; 2 years of Maclet 5 Tablet followed by 3 years of tamoxifen.
If I am taking irbesartan to control my blood pressure, can I take Maclet 5 Tablet?
Yes, you can take irbesartan and Maclet 5 Tablet together. However, be careful and keep a regular check on your blood pressure since Maclet 5 Tablet may increase your blood pressure. Consult your doctor in case you have problems controlling your blood pressure.
Does Maclet 5 Tablet affect vision?
Although it is very uncommon but Maclet 5 Tablet may cause cataract. So, if you experience blurred vision or eye irritation, consult your doctor immediately.
My friend who is taking Maclet 5 Tablet often sweats a lot. Is it because of Maclet 5 Tablet?
This could be a sign of hot flushes which is a very common side effect of Maclet 5 Tablet. It happens due to decreased estrogen levels. The frequency of hot flushes reduces once your body adjusts to Maclet 5 Tablet. However, in some people the flushes and sweats may continue during the treatment and stop a few months after the treatment finishes. You can consult your doctor who will provide you a remedy if it is very bothersome.
What are the serious side effects of Maclet 5 Tablet?
The serious side effects do not occur in everyone and very few people experience them. The serious side effects of Maclet 5 Tablet include stroke, angina, heart attack, blood clotting, cataract, osteoporosis and severe skin reactions.
Does Maclet 5 Tablet cause bone loss?
Maclet 5 Tablet may cause thinning or wasting of your bones (osteoporosis), which is due to the decrease in estrogen levels in your body. Your doctor may decide to measure your bone density (a way of monitoring for osteoporosis) before, during and after treatment.
Can I take Maclet 5 Tablet for induction of ovulation in anovulatory infertility?
As per the Ministry of Health and Family Welfare, Maclet 5 Tablet is restricted for use in induction of ovulation in anovulatory infertility.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Moy B, Lee RJ, Smith M. Natural Products in Cancer Chemotherapy: Hormones and Related Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. New York, New York: McGraw-Hill Medical; 2011. p. 1762.
- Masters SB. Hypothalmic & Pituitary Hormones. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 718.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 786-87.
- Letrozole. East Hanover, New Jersey: Novartis Pharmaceuticals Corporation; 1997 [revised Jan. 2014]. [Accessed 03 Apr. 2019] (online) Available from:
- Central Drugs Standard Control Organisation (CDSCO). [Accessed 04 Apr. 2019] (online) Available from:
- National Health Service. Letrozole. [Last Reviewed: 21 Jul 2020]. [Accessed 08 Jul. 2023]. (online) Available from:
- Letrozole [Package Insert]. Mumbai, India: HOPE Lifecare. [Accessed 08 Jul. 2023]. (online) Available from:
- Letrozole [Prescribing Information]. East Hanover, New Jersey: Novartis Pharmaceuticals Corporation; 2020. [Accessed 08 Jul. 2023]. (online) Available from:
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Name: Unimac Pharmaceuticals Pvt Ltd
Address: 19,9th floor,Plot no.10, Vishal Tower Janak Puri, New Delhi-58
Country of origin: India
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