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Luprohal 3.75 Injection

Written By Dr. Lipika Khurana, PGDHHM, BDS
Reviewed By Dr. Rajeev Sharma, MBA, MBBS
Last updated on 10 Dec 2025 | 01:00 AM (IST)
Luprohal 3.75 Injection is used in the treatment of prostate cancer. It is also used to treat endometriosis (endometrium of the uterus grows excessively and causes symptoms like pain, heavy or irregular periods), uterine fibroids and central precocious puberty (very early puberty).
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Luprohal 3.75 Injection is currently sold out
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LuPRIDE Depot 3.75mg Injection
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Luprohal 3.75 Injection
Luprohal 3.75 Injection
vial of 1 ml Injection
₹2941
₹3268.13
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Same composition
LuPRIDE Depot 3.75mg Injection
LuPRIDE Depot 3.75mg Injection
vial of 1 Injection
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₹3002
₹2552.0 per ml

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General Information

The content is shown in English
Luprohal 3.75 Injection image
Luprohal 3.75 Injection image

Product introduction

Luprohal 3.75 Injection is given as an injection under the skin by a qualified medical professional.  Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

Decreased libido, increased sweating, fatigue, muscle weakness, and hot flashes are some very common side effects of this medicine. The long-term use of medicine may cause weakened bones and a reduction in bone mineral density. You are advised to take vitamin D and calcium supplements while taking this medicine. It might cause menstrual periods to stop for a period of 7- 12 weeks, inform your doctor if menstrual bleeding continues even during the treatment.

Before taking this medicine, inform your doctor if you have a history of drinking alcohol, smoking, and osteoporosis. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Luprohal Injection

Benefits of Luprohal Injection

Prostate cancer
Prostate cancer is a common cancer in men that often depends on testosterone to grow. Luprohal 3.75 Injection is used to lower testosterone levels, helping to slow or stop the growth of prostate cancer cells. It supports better disease control and improves outcomes when combined with other therapies.
Endometriosis
Endometriosis causes painful growth of uterine-like tissue outside the uterus, leading to chronic pelvic pain and fertility issues. Luprohal 3.75 Injection helps by reducing estrogen levels, which shrinks the abnormal tissue and relieves symptoms. It improves comfort and quality of life for those affected.
Uterine fibroids
Uterine fibroids are non-cancerous growths in the uterus that can cause heavy bleeding and pelvic discomfort. Luprohal 3.75 Injection reduces the size of fibroids by lowering hormone levels, easing symptoms and making surgical treatments, if needed, more manageable.
Precocious puberty (premature puberty)
Precocious puberty is early onset puberty in children, which can affect growth and development. Luprohal 3.75 Injection is used to safely delay puberty until the appropriate age, helping ensure normal physical and emotional development.

Side effects of Luprohal Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Luprohal
  • Decreased libido
  • Testicular atrophy
  • Increased sweating
  • Fatigue
  • Muscle weakness
  • Erectile dysfunction
  • Hot flashes

How to use Luprohal Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Luprohal Injection works

Luprohal 3.75 Injection reduces the amount of sex hormones (testosterone in men and estrogen in women). It works by decreasing the blood levels of testosterone in males. Luprohal 3.75 Injection also acts by shutting off hormones made by the ovaries (female reproductive organs), so the estrogen (one of the hormones that causes females to have periods) level is lowered.

Quick tips

  • Luprohal 3.75 Injection helps in the treatment of locally advanced or metastatic prostate cancer.
  • It may also be used to treat endometriosis and uterine fibroids.
  • It is given as an injection either under the skin or into a muscle.
  • It may cause dizziness and visual disturbances. Don't drive or do anything that requires mental focus until you know how it affects you.
  • It will cause menstrual periods to stop. Periods will resume 7-12 weeks after the final injection. Consult your doctor if you experience menstrual bleed despite treatment. 
  • Use non-hormonal methods of contraception such as condoms to prevent pregnancy during treatment, as this medicine may be harmful to a developing baby.
  • Long term treatment may lead to bone loss and a higher risk of bone fractures, especially if you are a heavy drinker, a smoker, or have a family history of osteoporosis.

Safety advice

Alcohol

Alcohol

CAUTION
Alcohol should be used with caution while taking Luprohal 3.75 Injection.
Pregnancy

Pregnancy

UNSAFE
Luprohal 3.75 Injection is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Information regarding the use of Luprohal 3.75 Injection during breastfeeding is not available. Please consult your doctor.
Driving

Driving

UNSAFE
Luprohal 3.75 Injection may cause side effects that could affect your ability to drive.
Do not drive or operate machinery if you experience drowsiness, dizziness or visual disturbances whilst being treated with Luprohal 3.75 Injection.
Kidney

Kidney

CONSULT YOUR DOCTOR
There is limited data available on the use of Luprohal 3.75 Injection in patients with kidney disease. Please consult your doctor.
Liver

Liver

CONSULT YOUR DOCTOR
There is limited data available on the use of Luprohal 3.75 Injection in patients with liver disease.

Frequently asked questions

No, Luprohal 3.75 Injection is not a chemotherapy medicine. Luprohal 3.75 Injection is a synthetic hormone analogue medicine which is used for the treatment of hormone-dependent conditions in men and women.
Yes, the periods tend to stop while taking Luprohal 3.75 Injection injections as this medicine alters the reproductive hormones in females. Sometimes, there can be vaginal bleeding in few cases. If this occurs, please contact your doctor to get yourself assessed and follow the direction of your doctor.
Yes, Luprohal 3.75 Injection is a hormonal medicine which alters the reproductive hormones when given in females. This medication is not recommended for use in women who are or may become pregnant because this can harm the fetus in the womb. Using this medicine during pregnancy may also lead to abortion of the baby. Do inform your doctor if you are pregnant or are planning to get pregnant before starting this medication.
Yes, there are chances of Luprohal 3.75 Injection affecting your bones. Using Luprohal 3.75 Injection may cause a decrease in bone mineral density and make the bones weaker. In women, bone density should be assessed before starting the treatment. Special care and monitoring should be done in women with increased risk of osteoporosis. If at all needed, additional medicines may be given to prevent the development of osteoporosis in patients with decreased bone mineral density.
Yes, Luprohal 3.75 Injection may cause an increase in blood sugar levels, worsening the blood glucose control in patients with diabetes. It can even increase the risk of developing diabetes. Therefore, you must monitor the blood glucose and/or glycosylated hemoglobin (HbA1c) from time to time to keep a track of the glucose control and inform your doctor in case you develop any problem. Diabetic patients when prescribed this medication should monitor the sugar levels more frequently while taking this treatment.

Fact Box

Chemical Class

Peptides

Habit Forming

No

Therapeutic Class

GYNAECOLOGICAL

Action Class

Gonadotropin-releasing hormone (GnRH) Agonists

References

  1. Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 959.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 787-88.
  3. Leuprorelin acetate. Wooburn Green, High Wycombe: Takeda UK Ltd.; 2011 [revised 11 Jun. 2018]. [Accessed 25 Jan. 2019] (online) Available from:
  4. Leuprolide Leuprorelin acetate. Fort Collins: TOLMAR Inc.; 2002 [revised Feb. 2016]. [Accessed 26 Mar. 2019] (online) Available from:
  5. Leuprolide acetate [Prescribing Information]. Fort Collins, CO: TOLMAR Therapeutics, Inc.; 2016. [Accessed 20 Feb. 2024] (online) Available from:
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Halsted Pharma Private Limited
Address: Ground floor, Plot No.25-HIG, Survey No.912P. 913P, 941P, 944P 945 to 962 and 964P Phase XV, KPHB Colony, Kukatpally. Medchal- Malkajgiri District, Telangana State, India.

Vendor Details

Country of origin: India
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