JakAVI 20mg Tablet

Ruxolitinib (20mg)

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JakAVI 20mg Tablet is a medicine used to treat certain blood disorders, mainly chronic idiopathic myelofibrosis and polycythemia vera. These conditions affect how bone marrow makes blood cells. It works by blocking specific enzymes that play a key role in the signals that control blood cell production.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 23 Mar 2026 | 11:29 AM (IST)

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General Information

Contains

Ruxolitinib (20mg)

Marketer

Novartis India Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

JakAVI 20mg Tablet can be taken with or without food, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits, but do not stop taking it unless your doctor tells you to.

Headache, dizziness, and low platelet count are some common side effects of this medicine. This medicine may reduce the number of blood cells (decrease red blood cells) in your blood, thereby increasing your susceptibility to infections. Regular blood tests are required to check your blood cells, along with heart, liver, kidney, and lipid levels.

Before taking it, tell your doctor if you have liver or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine, so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of JakAVI Tablet

Treatment of Chronic idiopathic myelofibrosis
Treatment of Polycythemia vera

Benefits of JakAVI Tablet

Treatment of Chronic idiopathic myelofibrosis
Chronic idiopathic myelofibrosis is a rare bone marrow disorder where scar tissue forms inside the marrow, leading to symptoms like fatigue, anemia, and an enlarged spleen. JakAVI 20mg Tablet helps reduce spleen size and ease symptoms such as night sweats and bone pain, improving overall quality of life.

Treatment of Polycythemia vera
Polycythemia vera is a blood disorder where the body produces too many red blood cells, thickening the blood and increasing the risk of clots. JakAVI 20mg Tablet helps lower blood cell counts and control symptoms like itching and headaches, reducing the risk of serious complications.

Side effects of JakAVI Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of JakAVI

Anemia (low number of red blood cells)
Low blood platelets
Dizziness
Infection
Headache
Fatigue
Decreased white blood cell count (neutrophils)
Increased alanine aminotransferase
Bruising

How to use JakAVI Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. JakAVI 20mg Tablet may be taken with or without food.

How JakAVI Tablet works

JakAVI 20mg Tablet works by blocking two enzymes called JAK1 and JAK2, which send signals that control blood cell production and immune activity. In conditions like myelofibrosis and polycythaemia vera, these signals are overactive and lead to abnormal blood cell growth. In graft-versus-host disease, the same pathway causes excessive immune reactions. Reducing these signals helps control abnormal blood cell activity and calms harmful immune responses, improving disease-related symptoms.

Quick tips

JakAVI 20mg Tablet can be taken with or without food, but take it at the same time each day.
It may cause dizziness and headaches. Do not drive or do anything that requires mental focus until you know how it affects you.
Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine.
Your doctor may get regular blood tests done to monitor your blood cells, liver and kidney function, and lipid levels during treatment with this medicine.
Inform your doctor immediately if you notice any signs of infection, such as fever, sore throat, or rash.
Do not stop taking JakAVI 20mg Tablet without talking to your doctor first.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with JakAVI 20mg Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

JakAVI 20mg Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

UNSAFE

JakAVI 20mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

CONSULT YOUR DOCTOR

It is not known whether JakAVI 20mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.

Kidney

CAUTION

JakAVI 20mg Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Use of JakAVI 20mg Tablet is not advised in patients with moderate to severe kidney disease.

Liver

CAUTION

JakAVI 20mg Tablet should be used with caution in patients with severe liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking JakAVI with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate