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Isordil 5 Sublingual tablet

Isosorbide Dinitrate (5mg)
Genuine
Authenticity Assured
Prescription
required
Isordil 5 Sublingual tablet is used to prevent chest pain (angina attacks). It works by relaxing and widening blood vessels so blood can flow more easily to the heart. These tablets will not treat an angina attack that has already begun.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 03 Feb 2026 | 12:22 PM (IST)
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General Information

The content is shown in English
Isordil 5 Sublingual tablet image
Isordil 5 Sublingual tablet image
Isordil 5 Sublingual tablet image
Isordil 5 Sublingual tablet image
Isordil 5 Sublingual tablet image

Product introduction

Isordil 5 Sublingual tablet must be taken in the dose and duration as advised by the doctor. Place the tablet under the tongue or between the cheek and gum, and let it dissolve. It is usually taken as needed, either 5 to 10 minutes before physical activities or at the first sign of angina. You should take the medicine as it is prescribed for you and keep taking it, even if you feel well. If you stop taking it suddenly your risk of an angina attack will increase. Lifestyle changes such as diet, exercise, and not smoking may help this drug work better.

You can develop tolerance to this medicine over time, which means that the same dose becomes less effective. You have to stick to a really specific dosing schedule to prevent this from happening.

The most common side effects of this medicine include headache and lightheadedness. These may disappear once you have got used to the medicine. If you are worried, or the symptoms do not go away, let your doctor know. Some of these can be reduced by taking painkillers, drinking plenty of fluids, and avoiding alcohol. Alcohol may increase some side effects (dizziness, drowsiness, feeling light-headed, or fainting). Medical tests (such as blood pressure) may be required to monitor your progress and check for side effects.

Uses of Isordil Sublingual tablet

Benefits of Isordil Sublingual tablet

Angina (heart-related chest pain)
Angina is a type of chest pain caused by reduced blood flow to the heart, often triggered by physical activity or stress.Isordil 5 Sublingual tablet helps widen blood vessels, improving blood flow to the heart and reducing the strain on it. This relieves chest pain and helps prevent future angina episodes.

Side effects of Isordil Sublingual tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Isordil
  • Headache

How to use Isordil Sublingual tablet

Place the tablet under the tongue or between the cheek and gum, and let it dissolve. Do not chew, crush, or swallow the tablet. Isordil 5 Sublingual tablet may be taken with or without food.

How Isordil Sublingual tablet works

Isordil 5 Sublingual tablet is a nitrate. It works by relaxing the blood vessels which decreases the oxygen demand of the heart and reduces its workload, thereby preventing/treating attacks of angina (chest pain).

All substitutes for Isordil 5 Sublingual tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

  • Isordil 5 Sublingual tablet may cause dizziness or sleepiness. Do not drive or do anything that requires concentration until you know how it affects you.
  • Do not consume alcohol while taking Isordil 5 Sublingual tablet as it may cause increased dizziness.
  • It may cause headaches which usually go away after a few days of continued treatment. Inform your doctor if it persists.
  • You may develop tolerance to Isordil 5 Sublingual tablet with time, meaning that the same dose may be less effective next time. Follow the prescribed dosing schedule to avoid this.
  • Stop taking medications (prescribed for erectile dysfunction) like sildenafil or tadalafil while on treatment with Isordil 5 Sublingual tablet as it may cause low blood pressure.
  • You have been prescribed Isordil 5 Sublingual tablet for the prevention and treatment of heart-related chest pain (angina).
  • Eat healthy (low-fat, high-fiber, low-sodium diet), quit smoking, increase your physical activity, watch your weight and reduce stress.
  • Isordil 5 Sublingual tablet may cause dizziness or sleepiness. Do not drive or do anything that requires concentration until you know how it affects you.
  • Do not consume alcohol while taking Isordil 5 Sublingual tablet as it may cause increased dizziness.
  • It may cause headaches which usually go away after a few days of continued treatment. Inform your doctor if it persists.
  • You may develop tolerance to Isordil 5 Sublingual tablet with time, meaning that the same dose may be less effective next time. Follow the prescribed dosing schedule to avoid this.
  • Stop taking medications (prescribed for erectile dysfunction) like sildenafil or tadalafil while on treatment with Isordil 5 Sublingual tablet as it may cause low blood pressure.

Safety advice

Alcohol

Alcohol

UNSAFE
Consumption of alcohol with Isordil 5 Sublingual tablet may cause a disulfiram-like reaction, leading to symptoms such as flushing, increased heart rate, low blood pressure, nausea, lightheadedness, and severe headache.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of Isordil 5 Sublingual tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

SAFE IF PRESCRIBED
Isordil 5 Sublingual tablet may be safe to use during breastfeeding. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Driving

Driving

UNSAFE
Isordil 5 Sublingual tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

SAFE IF PRESCRIBED
Isordil 5 Sublingual tablet is safe to use in patients with kidney disease. No dose adjustment is recommended.
However, inform your doctor if you have an underlying kidney disease.
Liver

Liver

SAFE IF PRESCRIBED
Isordil 5 Sublingual tablet is probably safe to use in patients with liver disease. Limited data suggest dose adjustment may not be needed.

Interaction with drugs

Taking Isordil with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Life-threatening

Sildenafil (Oral Route)

Do not consume Sildenafil with Isosorbide Dinitrate. If Sildenafil is essential, ensure a gap of at least 24 hours after discontinuing Isosorbide Dinitrate. Please consult your doctor.
Life-threatening

Tadalafil (Oral Route)

Do not consume Tadalafil with Isosorbide Dinitrate. If Tadalafil is essential, ensure a gap of at least 48 hours between taking Tadalafil and Isosorbide Dinitrate.
Life-threatening

Sildenafil (Oral Route)

Do not consume Sildenafil with Isosorbide Dinitrate. If Sildenafil is essential, ensure a gap of at least 24 hours after discontinuing Isosorbide Dinitrate. Please consult your doctor.
Life-threatening

Sildenafil (Injection Route)

Do not consume Sildenafil with Isosorbide Dinitrate. If Sildenafil is essential, ensure a gap of at least 24 hours after discontinuing Isosorbide Dinitrate. Please consult your doctor.
Life-threatening

Sildenafil (Injection Route)

Do not consume Sildenafil with Isosorbide Dinitrate. If Sildenafil is essential, ensure a gap of at least 24 hours after discontinuing Isosorbide Dinitrate. Please consult your doctor.

Frequently asked questions

Isordil 5 Sublingual tablet belongs to a group of medicines known as nitrates. It is used to prevent angina (heart-related chest pain). This is done by widening the blood vessels and making blood flow easier. However, it is important to know that this medicine does not treat a chest pain that has already begun.
Isordil 5 Sublingual tablet works by widening the blood vessels in your heart to allow an increased amount of blood flow to areas which need it.
No, Isordil 5 Sublingual tablet does not lower heart rate. However, in some cases, one may experience reflex tachycardia (fast heart rate) while using nitrates such as Isordil 5 Sublingual tablet.
Yes, Isordil 5 Sublingual tablet lowers blood pressure. This medicine widens the blood vessels and decreases the resistance in them, causing a fall in blood pressure. This fall in blood pressure may in turn decrease the heartbeat which can lead to angina. This medicine should be avoided in people who already have low blood pressure. Discuss with your doctor if you have any concerns.
No, you should not take sildenafil along with Isordil 5 Sublingual tablet. Both these medicines lower blood pressure and belong to the same class. Taking these two medicines together may cause significant decrease in blood pressure which can cause fainting or even a heart attack. Along with this, avoid taking other medicines which belong to the same class such as vardenafil and tadalafil.

Fact Box

Chemical Class

Nitrates

Habit Forming

No

Therapeutic Class

CARDIAC

Action Class

Nitric Oxide (NO) Donors

References

  1. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 743-44.
  2. Isosorbide dinitrate [FDA Label]. Cologne, Germany: MEDA Manufacturing GmbH; 2015. [Accessed 05 Feb. 2020] (online) Available from:
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User feedback

Once A Day
100%
Angina (heart-related chest pain)
76%
Others
14%
Heart failure
10%
Average
50%
Poor
29%
Excellent
21%
No Side Effect
43%
Dizziness
14%
Increased heart rate
14%
Orthostatic hypotension (sudden lowering of blood pressure on standing)
14%
Headache
14%
Empty stomach
100%
Average
50%
Expensive
50%
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Ipca Laboratories Ltd
Address: 142 AB, Kandivli Industrial Estate, Kandivli (West), Mumbai - 400 067, Maharashtra

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Isordil 5 Sublingual tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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