Instgra Tablet belongs to a group of medicines called antiretrovirals. It is used to treat HIV (human immunodeficiency virus), the virus that can cause AIDS (acquired immunodeficiency syndrome). It prevents the multiplication of viruses in human cells and clears up your infection.
Instgra Tablet is not a cure for HIV or AIDS and only helps to decrease the amount of HIV in your body. This helps to lower your risk of getting HIV-related complications and improves your lifespan. It is prescribed in combination with other HIV medicines. Your doctor will recommend the best medicines for you and will decide the doses that you need. Follow the instructions carefully, for all the medicines that you are given. It may be taken with or without food, preferably at a fixed time. Taking all these medicines regularly at the right times greatly increases their effectiveness and reduces the chances of HIV becoming resistant to them. It is important not to miss doses and to keep taking them until your doctor tells you it is safe to stop.
Some common side effects include headache, insomnia (difficulty sleeping), dizziness, diarrhea, nausea, and fatigue. These are usually not serious but tell your doctor if they bother you or persist for a longer duration. Rarely, some people may experience a skin reaction or liver damage. Your doctor will closely monitor you for these in the initial period of treatment.
Before taking it, tell your doctor if you have any skin problems or liver or kidney disease. While using it, you may need regular blood tests to check your blood counts and liver function. Avoid drinking alcohol as it may increase your risk of liver damage. Pregnant or breastfeeding mothers should consult their doctor before using this medicine. Do not have unprotected sex or share personal items like razors or toothbrushes, if you are HIV positive. Talk to your doctor about safe ways like condoms to prevent HIV transmission during sex.
Instgra Tablet prevents HIV from multiplying in the body. It helps control the infection and make the immune system work better. This lowers the chances of getting complications, such as new infections, and improves the quality of life. This medicine is always taken in combination with other antiretroviral medicines.
It is not a cure of HIV or AIDS and should not be used to prevent HIV after accidental exposure to a risk. It is important to take this medicine as prescribed by the doctor. Taking all doses in the right amount at the right times greatly increases the effectiveness of this combination of medicines and reduces the chances of HIV infection becoming resistant to antiretroviral medicines. Although taking this medicine does not prevent the passing of HIV to other people.
Side effects of Instgra Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Instgra
Headache
Insomnia (difficulty in sleeping)
Dizziness
Diarrhea
Nausea
Fatigue
Muscle pain
Increased liver enzymes
Stomach pain
Itching
Abnormal dreams
Anxiety
How to use Instgra Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Instgra Tablet may be taken with or without food, but it is better to take it at a fixed time.
How Instgra Tablet works
Instgra Tablet is an anti-HIV medication. It prevents the multiplication of virus in human cells. This stops the virus from producing new viruses and clears up your infection.
Safety advice
Alcohol
CAUTION
Caution is advised when consuming alcohol with Instgra Tablet. Please consult your doctor.
Pregnancy
SAFE IF PRESCRIBED
Instgra Tablet is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Breast feeding
CONSULT YOUR DOCTOR
Instgra Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
UNSAFE
Instgra Tablet may cause side effects which could affect your ability to drive.
Kidney
SAFE IF PRESCRIBED
Instgra Tablet is safe to use in patients with kidney disease. No dose adjustment of Instgra Tablet is recommended.
Liver
CAUTION
Instgra Tablet should be used with caution in patients with liver disease. Dose adjustment of Instgra Tablet may be needed. Please consult your doctor.
What if you forget to take Instgra Tablet?
If you miss a dose of Instgra Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
No substitutes found for this medicine
Quick tips
Take Instgra Tablet with or without food, preferably at the same time everyday.
Do not skip any doses and finish the full course of treatment even if you feel better.
Do not take antacids or calcium supplements an hour before or two hours after taking Instgra Tablet.
Your doctor may monitor your liver function regularly during treatment. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.
Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
Fact Box
Chemical Class
Pyridinecarboxylic acids derivatives
Habit Forming
No
Therapeutic Class
ANTI INFECTIVES
Action Class
Integrase Strand Transfer Inhibitors (INSTIs)
Interaction with drugs
Taking Instgra with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
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i have unprotected sex with my friend. Can I take any drugs now to prevent any STD/HIV infection
Dr. Shyam Gupta
Obstetrics and Gynaecology
Hello PATIENT to 1mg. There is some medicine for prophylactic but you need to see physician for prescription and better you check HIV status of both partner
hello, one of my frnd suffering with hiv infection from last 2yrs her cd4 is more than 470 and viral load is zero undetectable now she is using art medicines i have doubt that can we have to use art medicine in the whole life or can we stop it once we get viral load zero
Dr. Atula Gupta
Dermatology
You still need to be on ART even if the viral load is undetectable
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References
Dolutegravir. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Acccessed 24 Jan. 2019] (online) Available from:
Dolutegravir. Prescribing information. Mumbai, India: Sun Pharmaceutical Industries Limited; 2025. [Accessed 09 Oct. 2025] (online) Available from: