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Glucobay M50 Tablet is an anti-diabetic drug used to treat type 2 diabetes mellitus in adults. It helps control blood sugar levels in people with diabetes.

Written By Dr. Subita Alagh, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 06 Apr 2026 | 01:31 PM (IST)
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The content is shown in English
Glucobay M50 Tablet image
Glucobay M50 Tablet image
Glucobay M50 Tablet image
Glucobay M50 Tablet image
Glucobay M50 Tablet image
Glucobay M50 Tablet image

Product introduction

Glucobay M50 Tablet should be taken with food. To get the most benefit, take it regularly at the same time each day. Your doctor will decide what dose is best for you, which may change depending on how it works and your blood sugar levels.

Keep taking this medicine, even if you feel well or your blood sugar levels are controlled. If you stop taking it without consulting your doctor, your blood sugar levels could rise, putting you at risk of kidney damage, blindness, nerve problems, and limb loss. As your doctor advises, you should follow a healthy diet, regular exercise, and weight reduction. Your lifestyle plays a big part in controlling diabetes.

Limited data is available for this combination. Some individuals may experience mild gastrointestinal side effects such as bloating, flatulence, abdominal discomfort, diarrhea, or nausea, especially during the initial phase of treatment. These effects are usually temporary and tend to improve as the body adjusts. If symptoms persist or become troublesome, consult a doctor.

You should not take it if you have type 1 diabetes mellitus if you have diabetic ketoacidosis (high levels of acid in your blood), or if you have severe kidney or liver disease. Before taking this medicine, tell your doctor if you have ever had heart disease. Pregnant or breastfeeding women should also consult their doctor before taking it. Your blood sugar levels should be checked regularly, and your doctor may advise blood tests to monitor your blood cell counts and liver function.

Uses of Glucobay M Tablet

Benefits of Glucobay M Tablet

Treatment of Type 2 diabetes mellitus
In Type 2 diabetes mellitus, the body either does not use insulin properly or does not produce enough, leading to high blood sugar levels. Glucobay M50 Tablet helps control blood sugar. It helps maintain more stable blood glucose levels throughout the day and supports better long-term diabetes management.

Side effects of Glucobay M Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Glucobay M
  • Limited data available

How to use Glucobay M Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Glucobay M50 Tablet should be taken with or after food.

How Glucobay M Tablet works

Glucobay M50 Tablet is a combination of acarbose and metformin. Acarbose works by slowing down the breakdown of complex sugars into simpler sugars. This reduces the post-meal rise in blood sugar. Metformin lowers the production and absorption of sugar in your body and allows better use of existing insulin.

Quick tips

  • You have been prescribed this combination medicine as it can control blood sugar better than metformin alone.
  • You should continue to exercise regularly, eat a healthy diet, and take your other diabetes medicines along with Glucobay M50 Tablet.
  • Take it with food to lower your chance of having an upset stomach.
  • It can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol, or if you delay or miss a meal. 
  • Always carry some sugary food or fruit juice if you experience hypoglycemia symptoms such as cold sweats, cool, pale skin, tremors, and anxiety.
  • Monitor your blood sugar level regularly while taking this medicine.
  • Tell your doctor immediately if you experience any deep or rapid breathing, persistent nausea, vomiting, or stomach pain, as Glucobay M50 Tablet may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood.
  • Let your doctor know if you feel excessively thirsty, pass urine more frequently, or get tired easily. These are signs of very high blood sugar levels, and your treatment may need to be adjusted.

Safety advice

Alcohol

Alcohol

UNSAFE
It is unsafe to consume alcohol with Glucobay M50 Tablet
Pregnancy

Pregnancy

SAFE IF PRESCRIBED
Glucobay M50 Tablet is generally considered safe to use during pregnancy. Animal studies do not indicate harmful effects. However, there are limited human studies.
Breast feeding

Breast feeding

SAFE IF PRESCRIBED
Glucobay M50 Tablet may be safe to use during breastfeeding. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Driving

Driving

CAUTION
Glucobay M50 Tablet may affect your driving ability if your blood sugar becomes too low or too high. Monitor your blood glucose and avoid driving if affected.
Kidney

Kidney

CAUTION
Glucobay M50 Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Use of Glucobay M50 Tablet is, however, not recommended in patients with severe kidney disease. Regular monitoring of kidney function is advisable while you are taking this medicine.
Liver

Liver

UNSAFE
Glucobay M50 Tablet is unsafe to use in patients with liver disease and should be avoided.

Frequently asked questions

Glucobay M50 Tablet is used to manage type 2 diabetes when diet and exercise alone are not enough to control blood sugar levels. It helps lower blood sugar and keeps it stable throughout the day.
People with severe kidney or liver problems, diabetic ketoacidosis, lactic acidosis, or allergies to any medicine present in Glucobay M50 Tablet should avoid using Glucobay M50 Tablet.
Although serious side effects of Glucobay M50 Tablet are rare, it may cause lactic acidosis, a serious condition with symptoms like weakness, muscle pain, trouble breathing, and stomach pain. Seek medical help immediately if you notice these symptoms.
Yes. Glucobay M50 Tablet may cause side effects such as gas, bloating, diarrhea, and stomach cramps, especially when you start taking this medicine. These usually improve with time.
By controlling blood sugar, Glucobay M50 Tablet helps reduce the risk of complications like eye problems, kidney damage, nerve damage, and delayed wound healing.

Fact Box

Habit Forming

No

Therapeutic Class

ANTI DIABETIC

References

  1. Salemi Z, Rafie E, Goodarzi M T. Effect of Metformin, Acarbose and Their Combination on the Serum Visfatin Level in Nicotinamide/Streptozocin-Induced Type 2 Diabetic Rats. Iran Red Crescent Med J. 2016;18(3):e23814. [Accessed 08 Apr. 2019] (online) Available from:
  2. Diabetes UK. Glucobay (Acarbose). [Accessed 08 Apr. 2019] (online) Available from:
  3. Metformin hydrochloride. Huddersfield, West Yorkshire: Genus Pharmaceuticals; 2011 [revised 8 Apr. 2017] [Accessed 31 Jan. 2019] (online) Available from:
  4. Metformin hydrochloride. Princeton, New Jersey: Bristol-Myers Squibb Company. [Accessed 08 Apr. 2019] (online) Available from:
  5. Acarbose [Product Monograph]. Ottawa, ON: Marcan Pharmaceuticals Inc.; 2019. [Accessed 20 Sept. 2021] (online) Available from:
  6. Joshi SR, Ramachandran A, Chadha M, et al. Acarbose plus metformin fixed-dose combination in the management of type 2 diabetes. Expert Opin Pharmacother. 2014;15(11):1611-20. [Accessed 20 Sept. 2021] (online) Available from:
  7. Liu Z, Zhao X, Sun W, et al. Metformin combined with acarbose vs. single medicine in the treatment of type 2 diabetes: A meta-analysis. Exp Ther Med. 2017;13(6):3137-3145. [Accessed 20 Sept. 2021] (online) Available from:
  8. Diabetes Community, UK. Glucobay (Acarbose). [Accessed 12th Sept. 2023] (online) Available from:
  9. Metformin hydrochloride [Product Label]. Princeton, NJ: Bristol-Myers Squibb Company. [Accessed 12th Sept. 2023] (online) Available from:
  10. Acarbose and metformin. Nagpur, Maharashtra: Innovators Pharmaceuticals Ltd.; [Accessed 06 Apr. 2026] (online)
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User feedback

Once A Day
60%
Twice A Day
40%
Type 2 diabetes mellitus
95%
Others
5%
Average
47%
Excellent
33%
Poor
20%
No Side Effect
100%
With food
100%
Average
100%
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Bayer Zydus Pharma Pvt Ltd
Address: Bayer House, Central Avenue, Hiranandani Estate, Thane (west) Thane 400607 India

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Glucobay M50 Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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