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MDS (Oral Pathology & Microbiology), BDS
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MD (Pharmacology), MBBS
Last updated on:
20 Aug 2019 | 04:30 PM (IST)
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Glimpure M1 Tablet SR


Overview

Introduction

Glimpure M1 Tablet SR is a medicine used in the treatment of type 2 diabetes. It is a combination of two medicines that effectively control blood sugar levels, when a single medication is not effective. It should be used along with a proper diet and regular exercise for best results. It should be taken with food to avoid the side effects like nausea and upset stomach.

Uses of Glimpure M Tablet SR

Glimpure M Tablet SR side effects

Common
  • Hypoglycemia (low blood sugar level)
  • Taste change
  • Nausea
  • Diarrhea
  • Stomach pain
  • Headache
  • Upper respiratory tract infection

How to use Glimpure M Tablet SR

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Glimpure M1 Tablet SR is to be taken with food.
Glimpure M1 Tablet SR may cause stomach upset if taken empty stomach.

How Glimpure M Tablet SR works

Glimpure M1 Tablet SR is a combination of two antidiabetic medicines: Glimepiride and Metformin. Glimepiride is a sulfonylurea which works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Metformin is a biguanide which works by lowering glucose production in the liver, delaying glucose absorption from intestines and increasing the body's sensitivity to insulin.

Glimpure M Tablet SR related warnings

Alcohol
CAUTION
It is unsafe to consume alcohol with Glimpure M1 Tablet SR. Taking metformin with alcohol can cause lactic acidosis and you may experience malaise, respiratory distress, slow or irregular heartbeat, sleepiness, stomach upset, or other unusual symptoms.
Pregnancy
WEIGH RISKS VS BENEFITS
Glimpure M1 Tablet SR may be unsafe to use during pregnancy.
Animal studies have shown adverse effects on the fetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
Lactation
Glimpure M1 Tablet SR is probably safe to use during lactation. Limited human data suggests that the drug does not represent a significant risk to the baby.
Driving
Your ability to drive may be affected if your blood sugar is low or high. If this happens, do not drive.
Kidney
CAUTION
Glimpure M1 Tablet SR should be used with caution in patients with kidney disease. Dose adjustment of Glimpure M1 Tablet SR may be needed. Please consult your doctor.
Use of Glimpure M1 Tablet SR is, however, not recommended in patients with severe kidney disease. Regular monitoring of kidney function test is advisable while you are taking this medicine.
Liver
CAUTION
Glimpure M1 Tablet SR should be used with caution in patients with liver disease. Dose adjustment of Glimpure M1 Tablet SR may be needed. Please consult your doctor.
Glimpure M1 Tablet SR is generally started with low dose in patients with mild to moderate liver disease and its use is not recommended in patients with severe liver disease.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
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Expert Advice

  • Monitor your blood sugar level regularly while you are taking this medicine. 
  • It can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal. 
  • Inform your doctor about your diabetes treatment if you are due to have surgery under a general anesthetic.
  • Tell your doctor immediately if you experience any deep or rapid breathing or if you have persistent nausea, vomiting, and stomach pain as Glimpure M1 Tablet SR may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood.
  • Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).

Patient Concerns

Questions Related to Glimpure M

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I am suffering from type 2 diabetes my current sugar level BSF 166 and PP 225 currently i take amryl m forte 1 tablet once daily
Dr. Sanjay Bhatt
Diabetes Specialist
It is not good control.A person can control his or her sugar levels by regular exercise and walk or regular aerobic exercises at least 30 to 45 minutes per day.MEDICAL NUTRITIONAL THERAPY THAT IS TO MAINTAIN CALORIES INTAKE AS PER BMI .TAKE HELP OF DIABETIC EDUCATOR. VISIT YOU DOCTOR AND LOW ALL WHAT DOCTOR SUGGESTED.IN TIME ALL ROUTINE INVESTIGATIONS SHOULD BE DONE.you souls not treat it as disease but start of a healthy life.Uncontrolled sugar levels for long time leads to lower limb weakness which is neuropathy and which is followed by foot ulcers and other complications.online prescription is not allowed without seeing pt.so contact doctor nearby for any change or dose adjustment or visit my clinic at gurgaon sector 52 RdCity snergy multi speciality clinic near SRS MARKET
I am suffering from type 2 diabetes. Doctors prescribed me sugar about 6 months ago. I m taking ime9 tablet but my sugar levels keep fluctuating.also my leg pain doesn't go. It seems that I hv blood clots in legs. Do I have to take something to thin my blood also I dnt feel hungry at all being a sugar patient. Please advise what needs to be done because I can't afford expensive treatment because my husband doesn't do anything
Dr. Sanjay Bhatt
Diabetes Specialist
A person can control his or her sugar levels by regular exercise and walk or regular aerobic exercises at least 30 to 45 minutes per day.MEDICAL NUTRITIONAL THERAPY THAT IS TO MAINTAIN CALORIES INTAKE AS PER BMI .TAKE HELP OF DIABETIC EDUCATOR. VISIT YOU DOCTOR AND FOLLOW ALL WHAT DOCTOR SUGGESTED.IN TIME ALL ROUTINE INVESTIGATIONS SHOULD BE DONE.you should not treat it as disease but start of a healthy life.Uncontrolled sugar levels for long time leads to lower limb weakness which is neuropathy and which is followed by foot ulcers and other complications.online prescription is not allowed without seeing pt.so contact doctor nearby for any change or dose adjustment or visit my clinic at gurgaon sector 52 RdCity snergy multi speciality clinic near SRS MARKET
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User Feedback


FAQs

Q. What are the recommended storage conditions for Glimpure M?

Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

Q. Can the use of Glimpure M lead to lactic acidosis?

Yes, the use of Glimpure M can lead to lactic acidosis. It is a medical emergency which is caused by increased levels of lactic acid in the blood. It is also known as MALA (Metformin-associated lactic acidosis). It is a rare side effect associated with the use of metformin and therefore, it is considered to be harmful for patients with underlying kidney disease, old age patients or who take large amounts of alcohol. Symptoms of lactic acidosis may include muscle pain or weakness, dizziness, tiredness, feeling of cold in arms and legs, difficulty in breathing, nausea, vomiting, stomach pain or slow heart rate. If you have these symptoms, stop taking Glimpure M and consult your doctor immediately.

Q. What is Glimpure M?

Glimpure M is a combination of two medicines: Glimepiride and Metformin. This medicine is used in the treatment of type 2 diabetes mellitus (DM). It improves blood glucose levels in adults when taken along with proper diet and regular exercise. Glimepiride lowers the blood glucose levels by increasing the release of insulin from the pancreas. Metformin works by lowering the glucose production in the liver and improving insulin sensitivity. This combination is not indicated for the treatment of type 1 DM.

Q. What are the possible side effects of Glimpure M?

The use of Glimpure M is associated with common side effects like hypoglycemia (low blood sugar level), altered taste, nausea, stomach pain, diarrhea, headache and upper respiratory tract infection. Its use can also lead to serious but rare side effects like lactic acidosis. On long-term use it can also lead to Vitamin B12 deficiency.

Q. Can the use of Glimpure M lead to Vitamin B12 deficiency?

Yes, the use of Glimpure M can cause Vitamin B12 deficiency on long-term use. It interferes with the absorption of Vitamin B12 in the stomach. If untreated, it may cause anemia and nerve problems and the patient can experience tingling sensation and numbness in hands and feet, weakness, urinary problems, change in mental status and difficulty in maintaining balance (ataxia). To avoid such problems, some researchers suggest an intake of Vitamin B12 from outside sources at least once every year.

Q. Can the use of Glimpure M cause hypoglycemia?

Yes, the use of Glimpure M can cause hypoglycemia (low blood sugar level). Symptoms of hypoglycemia include nausea, headache, irritability, hunger, sweating, dizziness, fast heart rate and feeling anxious or shaky. It happens more often if you miss or delay your food, drink alcohol, over-exercise or take other antidiabetic medicine along with it. So, regular monitoring of the blood sugar level is important. Always keep a quick source of sugar like glucose tablets, honey or fruit juice with you.

Q. Is it safe to take alcohol while I am also taking Glimpure M?

No, it is not safe to take Glimpure M along with alcohol, as it may lower your blood sugar levels and lead to hypoglycemia. It can also increase the chances of lactic acidosis.

Related Products

Disclaimer: 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
References
  1. Glimepiride + Metformin. Karachi, Pakistan: Sanofi-Aventis Pakistan Ltd. [Accessed 23 Jan. 2019] (online) Available from:External Link
  2. Metformin Hydrochloride Prolonged Release & Glimepiride Tablets I.P. Ankleshwar: Sanofi India Limited; 2018. [Accessed 08 Apr. 2019] (online) Available from:External Link
  3. Glimepiride. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC.; 2009. [Accessed 08 Apr. 2019] (online) Available from:External Link
  4. Metformin hydrochloride. Princeton, New Jersey: Bristol-Myers Squibb Company. [Accessed 08 Apr. 2019] (online) Available from:External Link
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