Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Glim Total 2 Tablet is to be taken with food. Glim Total 2 Tablet may cause stomach upset if taken empty stomach.
Glim Total 2 Tablet is a combination of three antidiabetic medicines: Glimepiride, Metformin and Pioglitazone. They work by different mechanisms to provide better control of blood sugar when single or dual therapy is not effective. Glimepiride is a sulfonylurea which works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Metformin is a biguanide. It works by lowering glucose production in the liver, delaying glucose absorption from intestines and increasing the body's sensitivity to insulin. Pioglitazone is a thiazolidinedione which further increases insulin sensitivity.
Taking pioglitazone with alcohol may affect blood glucose levels in patients with diabetes.
WEIGH RISKS VS BENEFITS
Glim Total 2 Tablet may be unsafe to use during pregnancy. Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
Glim Total 2 Tablet is probably safe to use during lactation.
Limited human data suggests that the drug does not represent a significant risk to the baby. Monitor the breastfed baby’s blood sugar during treatment with Glim Total 2 Tablet
Your ability to drive may be affected if your blood sugar is low or high. If this happens, do not drive.
Glim Total 2 Tablet should be used with caution in patients with kidney disease. Dose adjustment of Glim Total 2 Tablet may be needed. Please consult your doctor. Use of Glim Total 2 Tablet is, however, not recommended in patients with severe kidney disease. Regular monitoring of kidney function test is advisable while you are taking this medicine.
Glim Total 2 Tablet should be used with caution in patients with liver disease. Dose adjustment of Glim Total 2 Tablet may be needed. Please consult your doctor. Use of Glim Total 2 Tablet is not recommended in patients with severe liver disease.