Fludaphos 50mg Injection

Fludarabine (50mg)

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Cold stored

Stored between 2-8°C

Fludaphos 50mg Injection is used in the treatment of blood cancer called chronic lymphocytic leukemia (CLL). It may be used to treat other conditions, as determined by the doctor. It is sometimes used with certain other medicines as part of combination chemotherapy.

Written By Dr. Swati Mishra, BDS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 14 Apr 2026 | 01:19 PM (IST)

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General Information

Contains

Fludarabine (50mg)

Marketer

Bharat Serums & Vaccines Ltd

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.

The content is shown in English

Product introduction

Fludaphos 50mg Injection is given as infusion into veins under the supervision of doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine include nausea, vomiting, diarrhea, headache, weakness, fever, and cough. This medicine may reduce the number of blood cells (decrease white blood cells and red blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels.

Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Fludaphos Injection

Blood cancer (Chronic lymphocytic leukemia)

Benefits of Fludaphos Injection

Blood cancer (Chronic lymphocytic leukemia)
Blood cancer, also called leukemia, is a cancer of the blood-forming tissues, that decreases the body's ability to fight infection. Fludaphos 50mg Injection kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is an effective medicine but you should discuss the side effects and benefits of this medicine with your doctor. Let your doctor know if any of the side effects bothers you.

Side effects of Fludaphos Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Fludaphos

Increased risk of infection
Vomiting
Weakness
Nausea
Fatigue
Fever
Decreased blood cells (red cells, white cells, and platelets)
Diarrhea
Cough

How to use Fludaphos Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Fludaphos Injection works

Fludaphos 50mg Injection is an anticancer medication. It works by interfering with the growth of genetic material (DNA and RNA) of the cancer cells in blood. This slows the growth of cancer cells and eventually kills them.

All substitutes for Fludaphos 50mg Injection

For information purposes only. Consult a doctor before taking any medicine.

Fludarither 50 Injection

by Therdose Pharma Pvt Ltd

₹6000/injection

15% costlier

Quick tips

Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine.
Inform your doctor immediately if you notice any signs of infection such as fever, sore throat, rash or severe diarrhea.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Fludaphos 50mg Injection. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Fludaphos 50mg Injection is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

UNSAFE

Fludaphos 50mg Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

UNSAFE

Fludaphos 50mg Injection may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Some people get tired, feel weak, have disturbed vision, become confused, or agitated or have seizures while they are treated with Fludaphos 50mg Injection and this may affect your ability to drive.

Kidney

CAUTION

Fludaphos 50mg Injection should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Use of Fludaphos 50mg Injection is not recommended in patients with severe kidney disease.

Liver

CONSULT YOUR DOCTOR

There is limited data available on the use of Fludaphos 50mg Injection in patients with liver disease.

Interaction with drugs

Taking Fludaphos with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Life-threatening

Pegfilgrastim (Injection Route)

Do not consume Fludarabine from 14 days before until 24 days after taking Pegfilgrastim. Please consult your doctor.

Life-threatening

Sargramostim (Injection Route)

Do not consume Fludarabine from 1 day before until 1 day after taking Sargramostim. Please consult your doctor.

Life-threatening

Lenograstim (Injection Route)

Do not consume Lenograstim from 24 hours before until 24 hours after undergoing cytotoxic chemotherapy.

Life-threatening

Molgramostim (Injection Route)

Do not consume Fludarabine from 1 day before until 1 day after taking Molgramostim. Please consult your doctor.

Life-threatening

Natalizumab (Injection Route)

Do not consume Natalizumab with Fludarabine.

Frequently asked questions

What is Fludaphos 50mg Injection used to treat?

Fludaphos 50mg Injection is a chemotherapy medicine used to treat certain types of blood cancers, primarily B-cell chronic lymphocytic leukemia (CLL). It may also be used for other blood cancers such as non-Hodgkin’s lymphoma and acute myeloid leukemia.

How often will I need to get Fludaphos 50mg Injection?

A typical treatment schedule with Fludaphos 50mg Injection involves receiving the medicine once a day for five consecutive days. This five-day treatment cycle is usually repeated every 28 days. Your doctor will determine the exact number of cycles you need.

My doctor said Fludaphos 50mg Injection is for “refractory” CLL. What does that mean?

If your doctor prescribed Fludaphos 50mg Injection for refractory CLL, this means that your chronic lymphocytic leukemia has either not responded to previous standard treatments or it has come back after you have been treated with at least one other type of chemotherapy, such as an alkylating agent.

Will I need to have a lot of blood tests during my Fludaphos 50mg Injection treatment?

Yes. You will need to have frequent blood tests. Fludaphos 50mg Injection can significantly affect your bone marrow, which can lead to low levels of red blood cells, white blood cells, and platelets. Your doctor will monitor your blood counts closely to manage these effects.

Why is my doctor so concerned about infections while I am on Fludaphos 50mg Injection?

Fludaphos 50mg Injection works by targeting and destroying cancer cells, but it also strongly suppresses your immune system, which can last for a long time. This makes you much more vulnerable to serious infections, so it is very important to take precautions and report any signs of infection to your doctor right away.

I need a blood transfusion during Fludaphos 50mg Injection treatment. Is there anything special I need to know?

Yes. This is very important. If you need a blood transfusion while you are being treated with Fludaphos 50mg Injection, the blood products you receive must be irradiated (treated with radiation) first. This is to prevent a rare, but very serious complication called transfusion-associated graft-versus-host disease.

Fact Box

Chemical Class

Purine nucleosides

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Antimetabolites

Related lab tests

Complete Blood Count

Peripheral Smear Examination

References

Chabner BA, Bertino J, Cleary J, et al. Cytotoxic Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1702-703.
Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 948.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 555-56.
Fludarabine phosphate. Bedford, Ohio: Ben Venue Laboratories. [Accessed 27 Mar. 2017] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 27 Mar. 2019] (online) Available from:

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Bharat Serums & Vaccines Ltd
Address: 17th Floor, Hoechst House, Nariman Point, Mumbai – 400 021, Maharashtra, India.

Vendor Details

Country of origin: India

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Fludaphos 50mg Injection

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Fludaphos Injection

Benefits of Fludaphos Injection

Side effects of Fludaphos Injection

How to use Fludaphos Injection

How Fludaphos Injection works

All substitutes for Fludaphos 50mg Injection

Fludarither 50 Injection

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Pegfilgrastim (Injection Route)

Sargramostim (Injection Route)

Lenograstim (Injection Route)

Molgramostim (Injection Route)

Natalizumab (Injection Route)

Frequently asked questions

What is Fludaphos 50mg Injection used to treat?

How often will I need to get Fludaphos 50mg Injection?

My doctor said Fludaphos 50mg Injection is for “refractory” CLL. What does that mean?

Will I need to have a lot of blood tests during my Fludaphos 50mg Injection treatment?

Why is my doctor so concerned about infections while I am on Fludaphos 50mg Injection?

I need a blood transfusion during Fludaphos 50mg Injection treatment. Is there anything special I need to know?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Complete Blood Count

Peripheral Smear Examination

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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