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Fibristone 25 Tablet

Written By Dr. Syeda Aafia, MBA, BDS
Reviewed By Dr. Rajeev Sharma, MBA, MBBS
Last updated on 25 Feb 2026 | 11:36 AM (IST)
Fibristone 25 Tablet is a medicine used in the treatment of uterine fibroids, noncancerous growths in the uterus that can cause heavy bleeding, pain, and pressure. It blocks the hormone progesterone, which fibroids rely on to grow, helping shrink them and ease symptoms like heavy bleeding and pelvic pain.
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General Information

Contains

Mifepristone (25mg)

Marketer

Jagsonpal Pharmaceuticals Ltd

Storage

Store below 30°C
The content is shown in English
Fibristone 25 Tablet image
Fibristone 25 Tablet image
Fibristone 25 Tablet image
Fibristone 25 Tablet image
Fibristone 25 Tablet image
Fibristone 25 Tablet image

Product introduction

Take Fibristone 25 Tablet exactly as prescribed by your doctor. It can be taken with or without food. Try to take it at the same time every day to help build a routine. Follow all your doctor’s instructions while taking this medicine. Your doctor may also ask for regular check-ups or ultrasounds to see how well the medicine is working and to monitor for any side effects. Make sure to attend all appointments.


Some common side effects of Fibristone 25 Tablet include hot flushes, nausea, headache, dizziness, and tiredness. You may experience lighter periods, or they may stop for a while. These side effects are usually mild and go away on their own. If you notice unusual or heavy bleeding, persistent stomach pain, or any serious discomfort, let your doctor know immediately.


Before starting Fibristone 25 Tablet, inform your doctor if you have liver problems, anemia, or any bleeding disorders. This medicine is not recommended for women who are pregnant or planning to become pregnant, as it can harm the pregnancy. While on treatment, use a nonhormonal method of contraception to prevent pregnancy. Avoid using it along with other hormone treatments unless your doctor advises.

Uses of Fibristone Tablet

Benefits of Fibristone Tablet

Treatment of Uterine fibroids
Fibristone 25 Tablet helps reduce the size of the fibroids and control symptoms like heavy menstrual bleeding, pelvic pain, and pressure in women with uterine fibroids. Easing these symptoms helps improve energy levels, reduces the need for frequent sanitary product changes, and lowers the risk of anemia. Fibristone 25 Tablet allows women to manage their condition without undergoing invasive procedures, making daily life more comfortable and predictable. Overall, this medicine helps restore a better quality of life by giving patients more control over their bodies and daily routines.

Side effects of Fibristone Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Fibristone
  • Hot flashes
  • Nausea
  • Headache
  • Tiredness
  • Dizziness

How to use Fibristone Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Fibristone 25 Tablet may be taken with or without food.

How Fibristone Tablet works

Fibristone 25 Tablet works by blocking the action of progesterone, a hormone that plays a key role in the growth of uterine fibroids. Inhibiting progesterone receptors helps reduce fibroid size and helps control symptoms like heavy bleeding and pain associated with the condition.

Quick tips

  • Take Fibristone 25 Tablet at the same time every day to help maintain consistent levels in your body and avoid missed doses.
  • Do not stop taking the medicine on your own, even if symptoms improve. Always follow your doctor’s advice on how long to continue treatment.
  • Use nonhormonal contraception like condoms or a copper intrauterine device (IUD) during treatment, as this medicine can affect pregnancy.
  • Inform your doctor if you experience heavy or prolonged bleeding, abdominal pain, or missed periods beyond what is expected during treatment.
  • Attend all follow-up appointments, including ultrasound scans or blood tests, to monitor fibroid size and check for side effects early.
  • Eat a balanced diet rich in iron (like green leafy vegetables, lentils, or iron-fortified cereals) to help manage or prevent anemia, especially if you had heavy bleeding before starting treatment.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Fibristone 25 Tablet. Please consult your doctor.
Pregnancy

Pregnancy

UNSAFE
Fibristone 25 Tablet is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Information regarding the use of Fibristone 25 Tablet during breastfeeding is not available. Please consult your doctor.
Driving

Driving

CAUTION
Fibristone 25 Tablet may cause dizziness or weakness due to changes in blood pressure. Do not drive if these symptoms occur.
Kidney

Kidney

CAUTION
Fibristone 25 Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Liver

Liver

CAUTION
Fibristone 25 Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.

Frequently asked questions

Fibristone 25 Tablet is used to manage symptoms of uterine fibroids, such as heavy or prolonged menstrual bleeding, lower abdominal pain, and pressure in the pelvic area. It helps improve quality of life by shrinking the fibroids and making the symptoms more manageable without the need for surgery in many cases.
You may start to notice a reduction in bleeding and discomfort within a few weeks of starting treatment. However, significant shrinkage in fibroid size usually takes a few months. Your doctor will monitor your response to treatment and may adjust the dose or duration based on how well the medicine is working for you.
Yes, many women experience lighter periods or even temporary absence of menstruation while on Fibristone 25 Tablet. This is a common effect and usually not a cause for concern. Once the treatment is stopped, your periods typically return to normal within a few weeks.
Fibristone 25 Tablet can control symptoms and reduce fibroid size during treatment, but it does not cure fibroids permanently. The fibroids may grow back or symptoms may return after stopping the medicine. However, for many women, it offers a valuable non-surgical option to manage the condition effectively.
Fibristone 25 Tablet is not a hormone itself, but it acts on hormone receptors. It blocks the progesterone receptors in the uterus, which helps reduce the effects of progesterone on fibroid growth and menstrual bleeding.
Yes, pregnancy is still possible while taking Fibristone 25 Tablet. However, the medicine can harm an early pregnancy. Use a non-hormonal contraceptive method (like condoms or copper IUD) during treatment, unless you are specifically advised otherwise by your doctor.
Some medicines may interfere with how Fibristone 25 Tablet works. Always inform your doctor about all the medicines, supplements, or herbal products you are using. This helps avoid harmful interactions and ensures that the treatment remains safe and effective.
Yes, regular follow-ups are important while you're taking Fibristone 25 Tablet. Your doctor may recommend blood tests or ultrasound scans to check the size of the fibroids and ensure that your liver and overall health are not affected by the medicine. These check-ups help your doctor decide how long you should continue the treatment and whether any changes are needed.

Fact Box

Chemical Class

Oxosteroids

Habit Forming

No

Therapeutic Class

GYNAECOLOGICAL

Action Class

Antiprogestins

References

  1. Levin ER, Hammes SR. Estrogens and Progestins. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1184-85.
  2. Masters SB. Hypothalmic & Pituitary Hormones. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 716-17.
  3. Kulshrestha V, Kriplani A, Agarwal N, et al. Low dose mifepristone in medical management of uterine leiomyoma - an experience from a tertiary care hospital from north India. Indian J Med Res. 2013;137(6):1154-62. [Accessed 30 Jun. 2025] (online) Available from:
  4. Seth S, Goel N, Singh E, et al. Effect of mifepristone (25 mg) in treatment of uterine myoma in perimenopausal woman. J Midlife Health. 2013 Jan;4(1):22-6. [Accessed 30 Jun. 2025] (online) Available from:
  5. Signorah Healthcare: Mifepristone [Product Information]. [Accessed 30 Jun. 2025] (online) Available from:
  6. Medgrow Health Care: Mifepristone [Product Information]. [Accessed 30 Jun. 2025] (online) Available from:
  7. Samyatva Pharma: Mifepristone [Product Information]. [Accessed 30 Jun. 2025] (online) Available from:
  8. Aarushi Healthcare: Mifepristone 10/25 mg [Product Page]. [Accessed 30 Jun. 2025] (online) Available from:
  9. Mifepristone [Product Information]. Mohali, Punjab: Gynogen captab [Accessed 14 Jan. 2026] (online). Available from:
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Jagsonpal Pharmaceuticals Ltd
Address: T-210 J, Shahpur Jat, New Delhi - 110 049, India

Vendor Details

Country of origin: India

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