Feroxamine 400mg Injection is a medicine used in the treatment of chronic iron overload caused due to frequent blood transfusion. It helps in removing the excess iron from the body and reduces the risk of it causing organ damage.

Feroxamine 400mg Injection is generally administered by a healthcare professional. You should not self-administer this medicine.

Using of Feroxamine 400mg Injection may cause few side effects such as flushing (a sense of warmth in the face, ears, neck and trunk), rash, decreased blood pressure and abdominal pain. If the side effects persist or worsen, inform your doctor.

Uses of Feroxamine Injection

Benefits of Feroxamine Injection

In Iron overload

Iron overload is a condition where iron accumulates in the body due to repeated transfusions or certain medical conditions. If left unmanaged, it can damage the liver, heart, and other organs. Feroxamine 400mg Injection helps reduce iron levels in the body, lowering the risk of long-term complications and supporting organ health.

In Transfusion dependent thalassemia

Transfusion-dependent thalassemia is a blood disorder where the body cannot make enough healthy red blood cells, leading to severe anemia. To manage this, patients require frequent blood transfusions, which gradually lead to a buildup of excess iron in the body. Feroxamine 400mg Injection helps by binding to this excess iron and removing it through urine and stool. This supports safe long-term transfusion therapy by preventing iron from harming vital organs.

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Side effects of Feroxamine Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Feroxamine

Flushing (sense of warmth in the face, ears, neck and trunk)
Rash
Decreased blood pressure
Abdominal pain

How to use Feroxamine Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Feroxamine Injection works

Feroxamine 400mg Injection traps and removes excess iron which is then excreted mainly in the stools. This reduces the risk of organ damage.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Feroxamine 400mg Injection. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Feroxamine 400mg Injection during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

SAFE IF PRESCRIBED

Feroxamine 400mg Injection may be safe to use during breastfeeding. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

Driving

UNSAFE

Feroxamine 400mg Injection may cause side effects that could affect your ability to drive.
If you experience dizziness or other central nervous disturbances, or impairment of vision with the use of Feroxamine 400mg Injection then you should refrain from driving a vehicle.

Kidney

CAUTION

Feroxamine 400mg Injection should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Use of Feroxamine 400mg Injection is not recommended in patients with severe kidney disease.

Liver

CONSULT YOUR DOCTOR

There is limited data available on the use of Feroxamine 400mg Injection in patients with liver disease.

What if you forget to take Feroxamine Injection?

If you miss a dose of Feroxamine 400mg Injection, contact your doctor as soon as possible. They will advise you on how to proceed, which may include rescheduling the missed dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

No substitutes found for this medicine

Quick tips

Feroxamine 400mg Injection is used to reduce excess iron from the body.
Feroxamine 400mg Injection may cause your urine to turn a red/brown color. This is the iron being removed from your body and is nothing for you to worry about as it is quite harmless.
If you are taking any antacid, take them 2 hours before or after Feroxamine 400mg Injection.
Feroxamine 400mg Injection may cause dizziness. It is advisable not to drive or operate any machinery until you feel normal again.
Inform your doctor if you have any liver or kidney disease.
Inform your doctor if you are pregnant or breastfeeding.

Fact Box

Chemical Class

Acetohydroxamic acids

Habit Forming

Therapeutic Class

BLOOD RELATED

Action Class

Iron Chelators

Interaction with drugs

Taking Feroxamine with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Prochlorperazine (Oral Route) Moderate

If concurrent use is essential, please consult your doctor. Prochlorperazine may increase the side effects of Deferoxamine.

Prochlorperazine (Injection Route) Moderate

If concurrent use is essential, please consult your doctor. Prochlorperazine may increase the side effects of Deferoxamine.

View all drug interactions

Patient concerns

Hello doctor I have thallassemia major since birth and due to iron overload of repetitive blood transfusion i have diagnosed with diabetes 3 yr ago -at the time of diabetes diagnosis my sugar level is 650 mg/dl. Now according to my case what could be the state of my diabetes type 1 or type 2 ?

Dr. Amit Modi

Paediatrics

Hello, Diabetes in thalassaemia is thought to be caused mainly by iron overload, from repeated blood transfusions, damaging the pancreas. Insulin secretion may be reduced, possibly because iron is directly toxic to the insulin producing pancreatic ?-cells. So it is type 1 DM .

Diabatic for last 4 years insulin dependent D Vitamin iron deficiency

Dr. Ila Jain Khandelwal

Pathology

Dear Sir Thank you for sharing your reports with me. It shows the following important things: 1. your iron level is low, for this you can have a diet rich in lots of iron like jaggery, spinach, leafy vegetables etc. Your vitamin D level is low, for this you can have calcirol sachet in milk once a week for at least 6 weeks. Your glycosylated hemoglobin and average blood glucose level is high, you should consult your doctor for this for the review of treatment.

Diabatic for last 5 years insulin dependent D Vitamin iron deficiency

Dr. Sanjay Bhatt

Physician

Hi you need to consult doctor nearby by.Or u can visit our clinic at sector 52 gurgaon in RDCITY snergy clinic. Diabetic pt should be in regular contact with the diabetologist or treating doctor. Do all regular tests and follow diet and exercise. Disease can be well controlled. A person can avoid diabetic complications.

H.B is just 7 gram not improving iron not suitable

Dr. Gopal Bansilal Samdani

Paediatrics

Please consult Dr. will take detail history and will examine your child in detail. may ask you for blood test. All information will be used to determine exact underlying cause of problem. Depending upon cause will prescribe you treatment.Just to give you idea i am giving examples of diseases where anemia is presentCongenital dyserythropoietic anemia Diamond-Blackfan anemia G-6-PD deficiency Hemophagocytic lymphohistiocytosis (HLH), congenital or acquired Iron refractory iron deficiency anemia (IRIDA) Nutritional iron deficiency Paroxysmal nocturnal hemoglobinuria Pure red cell aplasia Rheumatoid arthritis Sideroblastic anemia Unstable hemoglobinopathies Hookworm infection Hypothyroidism Myelodysplastic syndrome Myelofibrosis Systemic lupus erythematosus Thalassemia Thalassemia intermedia Pyruvate kinase deficiency

Related lab tests

Iron Serum

Iron Studies

Total Iron Binding Capacity

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Byrns MC, Penning TM. Environmental Toxicology: Carcinogens and Heavy Metals. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1875-76.
Kosnett MJ. Heavy Metal Intoxication & Chelators. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 1010.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 365-66.
Deferoxamine. Stein, Switzerland: Novartis Pharma Stein AG; 2011. [Accessed 6 Apr. 2019] (online) Available from: