Prochlorperazine

Written By Dr. Syeda Aafia

Reviewed By Dr. Rajeev Sharma

Last updated 25 Nov 2025 | 09:34 AM (UTC)

Prochlorperazine Uses

Prochlorperazine is used in nausea, vomiting, migraine, vertigo and short term anxiety.

Available generics for Prochlorperazine

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How Prochlorperazine works

Prochlorperazine is a dopamine antagonist. Dopamine controls the region in the brain that causes nausea and vomiting and this medicine blocks the action of dopamine. Therefore, Prochlorperazine shows an antiemetic action. Prochlorperazine suppresses the vestibular apparatus in the inner ear and stops vertigo. The mechanism of action by which neuroleptics like prochlorperazine relieve headache is probably related to the dopamine D2 receptor antagonist. It has an antipsychotic effect by blocking the action of dopamine, which also affects thoughts and mood. So, it also helps to relieve short-term anxiety as well.

Common side effects of Prochlorperazine

Dystonia (involuntary muscle contractions), Akathisia (inability to stay still), Parkinsonism, Tardive dyskinesia, Insomnia (difficulty in sleeping), Agitation, Convulsion

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Medicine brands for Prochlorperazine

Shreya Life Sciences Pvt Ltd

Unimarck Healthcare Ltd

₹37 to ₹67

2 variant(s)

Westel

Key West Medicines Pvt Ltd

Leeford Healthcare Ltd

Intas Pharmaceuticals Ltd

₹13 to ₹20

3 variant(s)

Expert advice for Prochlorperazine

Prochlorperazine is used for the prevention and treatment of nausea and vomiting.
It may also be used to treat dizziness associated with problems of the inner ear such as Meniere’s Syndrome.
It may cause sleepiness. Don't drive or do anything requiring concentration until you know how it affects you.
To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
Avoid consuming alcohol when taking the Prochlorperazine as it may cause excessive drowsiness.
It makes you more likely to get heatstroke. Avoid heavy exercising and drink plenty of fluids.
It can cause your skin to be more sensitive to sunlight. Avoid exposure to direct sunlight while having this medicine.

Frequently asked questions for Prochlorperazine

Q. How does Prochlorperazine work?

Prochlorperazine is used to treat mental disorders like schizophrenia. It is also used to treat and prevent nausea, and vomiting.It may be used to treat anxiety (short-term) in certain cases where other anti-anxiety drugs have been ineffective. It is also used to treat nausea, vomiting, dizziness or spinning sensations (vertigo) due to Meniere's disease.It belongs to a class of medication call phenothiazines. It acts on the central nervous system by blocking certain receptors thus producing an anti-psychotic and anti-vomiting effect

Q. Does Prochlorperazine expire?

Yes, Prochlorperazine does expire. Please check the expiry date written on the pack and it refers to the last day of that month. Do not use Prochlorperazine after the expiry date.

Q. Is Prochlorperazine available over the counter?

Prochlorperazine is not available over the counter. It is available only on prescription from the doctor

Q. Is Prochlorperazine safe to use?

Prochlorperazine is safe to use for a prescribed duration in the dose as advised by a doctor.

Q. How long can I take Prochlorperazine for?

Prochlorperazine should only be taken for the duration as advised by the doctor for your condition.

Q. Is Prochlorperazine addictive?

Prochlorperazine is not known to have any addictive potential. Please consult your doctor in case you have any other query regarding the same.