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Everotas 0.25 Tablet

Everolimus (0.25mg)

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Product Summary :

Everotas 0.25 Tablet contains everolimus. It works by reducing signals involved in cell growth and immune activity. Take it once daily at the same time, consistently with or without food. Common side effects include mouth sores, infections, rash, and tiredness. Avoid grapefruit and grapefruit juice during treatment.

Written By Dr. Subita Alagh, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 12 Nov 2026 | 01:02 AM (IST)

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Everolimus (0.25mg)

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General Information

Contains

Everolimus (0.25mg)

Marketer

Intas Pharmaceuticals Ltd

Storage

Store below 25°C

The content is shown in English

Product introduction

Everotas 0.25 Tablet is used in certain cancers and to suppress immune activity after some organ transplants. Its exact use and treatment plan depend on the condition being treated.

Everotas 0.25 Tablet must be taken in a dose and duration as per the prescription. It can be taken with or without food but make sure to take it at about the same time every day. An overdose of this medicine may have serious side effects on the body.

The common side effects of this medicine include infection, fever, cough, fatigue, headache, and rash. If any of the side effects persist or bother you, consult the doctor immediately. Inform the doctor immediately if you experience any allergic reactions (rash, shortness of breath, coughing, swelling, etc.). Always seek medical advice if you have increased thirst or increased frequency of urination, or need to receive any vaccination after taking this medication.

Before taking this medicine, it is important to consult your doctor if you have any ongoing medication for any underlying disease. Pregnant and breastfeeding women must inform the doctor prior to the initiation of this treatment. During the treatment, your doctor may advise you for some laboratory tests to know the effects of the medicine in the body. It may affect male or female fertility, so consult the doctor if you are planning to have a child.

Uses of Everotas Tablet

Treatment of Breast cancer : Used with exemestane in postmenopausal women with advanced hormone receptor-positive cancer; it is used when previous anticancer treatment has stopped working.
Prevention of Lung cancer : Helps to treat certain types of advanced lung cancer by slowing the growth and multiplication of cancer cells.
Treatment of Pancreatic cancer : Used to treat certain types of advanced pancreatic cancer by slowing cancer cell growth and division.
Treatment of Kidney cancer : Helps to treat certain advanced kidney cancers by slowing cancer cell growth and the formation of new blood vessels that support the tumor.
Prevention of organ rejection in transplant patients : Used as an immunosuppressant to help prevent the immune system from attacking a transplanted organ.

Benefits of Everotas Tablet

Treatment of Breast cancer
Hormone receptor-positive breast cancer uses hormones such as estrogen to help cancer cells grow. Everotas 0.25 Tablet is used with exemestane in postmenopausal women with advanced breast cancer.

Prevention of Lung cancer
Lung cancer develops when abnormal lung cells grow uncontrollably and may spread to other parts of the body. Everotas 0.25 Tablet blocks a protein involved in cell growth and multiplication. It can help slow the growth of certain lung cancers.

Treatment of Pancreatic cancer
Pancreatic cancer develops when abnormal cells grow uncontrollably in the pancreas and may spread to other parts of the body. Everotas 0.25 Tablet helps slow the growth of certain pancreatic cancers.

Treatment of Kidney cancer
Kidney cancer develops when abnormal cells grow uncontrollably in the kidney and may spread to other parts of the body. Everotas 0.25 Tablet helps reduce cancer cell growth and the formation of new blood vessels that can support tumor growth.

Prevention of organ rejection in transplant patients
After an organ transplant, the immune system may recognize the new organ as foreign and try to attack it, causing rejection. Everotas 0.25 Tablet suppresses certain immune responses, helping protect the transplanted organ and reduce the risk of rejection.

Side effects of Everotas Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Everotas

Stomatitis (Inflammation of the mouth)
Nausea
Anemia (low number of red blood cells)
Infection
Rash
Fatigue
Diarrhea
Edema (swelling)
Cough
Headache
Decreased appetite

How to use Everotas Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Everotas 0.25 Tablet may be taken with or without food.

How Everotas Tablet works

Everotas 0.25 Tablet is an mTOR (mammalian target of rapamycin) inhibitor. It works by blocking the activity of mTOR, a protein involved in cell growth, division, and survival. In cancer, it helps slow down the growth and multiplication of cancer cells. In organ transplant patients, it suppresses the activity of certain immune cells, particularly T-cells, helping prevent the immune system from attacking and rejecting the transplanted organ.

Dosage

Everotas 0.25 Tablet is usually taken by mouth once daily at about the same time each day. Your exact dose depends on the condition being treated, other medicines you take, liver function, and how well you tolerate treatment. Take it consistently either with food or without food.

All substitutes for Everotas 0.25 Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Everotas 0.25 Tablet is given for the treatment of certain cancers and to prevent organ transplant rejection.
Everotas 0.25 Tablet may affect male or female fertility; consult your doctor if you are planning to have a child.
Inform your doctor straight away if you think you are getting a sore throat or if you have a high temperature. This is because Everotas 0.25 Tablet increases your risk of getting an infection.
While you are taking Everotas 0.25 Tablet do not take any vaccinations without talking to your doctor first.
If you are having an operation or dental treatment, always tell the person carrying out the treatment that you are taking Everotas 0.25 Tablet.
Do not drink grapefruit juice while you are taking this medicine. This is because a chemical in grapefruit juice can interfere with the action of Everotas 0.25 Tablet.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Everotas 0.25 Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Everotas 0.25 Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

CONSULT YOUR DOCTOR

Everotas 0.25 Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.

Driving

CONSULT YOUR DOCTOR

It is not known whether Everotas 0.25 Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.
As fatigue is a common side effect with Everotas 0.25 Tablet and this may affect your ability to drive

Kidney

SAFE IF PRESCRIBED

Everotas 0.25 Tablet is safe to use in patients with kidney disease. No dose adjustment is recommended.

Liver

CAUTION

Everotas 0.25 Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.
Use of Everotas 0.25 Tablet is not recommended in patients with severe liver disease.

Interaction with drugs

Taking Everotas with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Life-threatening

Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted) (Injection Route)

Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted) should not be used while undergoing treatment with Everolimus or for up to 6 months after stopping Everolimus.

Life-threatening

Natalizumab (Injection Route)

Do not consume Natalizumab with Everolimus.

Severe

Cholera Vaccine (Inactivated) (Oral Route)

Cholera Vaccine (Inactivated) should not be used while undergoing treatment with Everolimus or for up to 6 months after stopping Everolimus.

Severe

Purified Vi Polysaccharide Typhoid Vaccine (Injection Route)

Purified Vi Polysaccharide Typhoid Vaccine should not be used while undergoing treatment with Everolimus or for up to 6 months after stopping Everolimus.

Severe

Temsirolimus (Injection Route)

Concurrent use should be avoided.

Frequently asked questions

Is Everotas 0.25 Tablet a chemotherapy?

Everotas 0.25 Tablet is an anticancer medicine. It belongs to kinase inhibitor class of medicines. It works by reducing the blood supply to the tumor, which slows down the growth and spread of cancer cells.

How is Everotas 0.25 Tablet administered?

Usually, Everotas 0.25 Tablet is taken once or twice daily. The medicine should always either be taken with food or always be taken without food. Everotas 0.25 Tablet should be swallowed whole with water and should not be crushed or chewed.

How long can you take Everotas 0.25 Tablet?

There is no definite duration of treatment with Everotas 0.25 Tablet. Everotas 0.25 Tablet is continued till clinical benefit is seen or unacceptable toxicity or side effects occur.

What should I avoid while taking Everotas 0.25 Tablet?

You should avoid grapefruit or grapefruit juice while taking Everotas 0.25 Tablet. This is because taking them together may increase the levels of Everotas 0.25 Tablet in your blood to harmful levels. Avoid the use of live vaccinations and any possible contact with individuals who have received live vaccinations.

What is the most important information I need to know about Everotas 0.25 Tablet?

Everotas 0.25 Tablet can cause serious side effects which include severe allergic reactions, angioedema, and kidney failure which can be severe and can lead to death. It is possible that you may develop an infection or problems related to lung such as breathing problems.

How will I know that Everotas 0.25 Tablet is shrinking my brain tumor?

The effect of Everotas 0.25 Tablet in shrinking the size of tumor can only be checked by getting regular brain scans. It should be done as advised by your doctor and your treatment plan.

Is Everotas 0.25 Tablet cytotoxic?

Yes, Everotas 0.25 Tablet is cytotoxic against human cancer cells of breast, stomach, prostate, and kidneys (renal cell carcinoma).

Is any monitoring required while taking Everotas 0.25 Tablet?

Regular monitoring is required while you are on Everotas 0.25 Tablet. The doctor will advise blood tests to see the counts of red blood cells, white blood cells, and platelets since the counts may decrease during treatment with Everotas 0.25 Tablet. Also, blood tests will be required to check your kidney function, liver function, blood glucose levels, and cholesterol levels.

Why might my doctor give me a special mouthwash when I start Everotas 0.25 Tablet?

Mouth ulcers and sores are common with Everotas 0.25 Tablet, particularly during the first weeks of treatment. An alcohol-free mouthwash may be prescribed when treatment starts to reduce their likelihood and severity.

What should I avoid using if I develop mouth sores?

Avoid mouthwashes or oral products containing alcohol, hydrogen peroxide, iodine, or thyme, as they may make mouth irritation worse.

Can Everotas 0.25 Tablet make me more likely to get infections?

Yes. Everotas 0.25 Tablet suppresses immune activity and can increase the risk of bacterial, viral, fungal, and other infections. Contact your doctor promptly if you develop fever, chills, or otherwise feel unwell.

Fact Box

Chemical Class

Macrolide lactams

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors

Related lab tests

Breast Cancer (CA 15.3/ ER/ PR)

Carcino Embryonic Antigen

Complete Blood Count

References

Krensky AM, Bennett WM, Vincenti F. Immunosuppressants, Tolerogens, and Immunostimulants. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. New York, New York: McGraw-Hill Medical; 2011. p. 1013.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 526.
Everolimus. East Hanover, New Jersey: Novartis Pharmaceuticals Corporation; 2009 [revised Apr. 2018]. [Accessed 06 Apr. 2019] (online) Available from:
Everolimus. Camberley, Surrey: Novartis Pharmaceuticals UK Ltd.; 2011 [revised 12 Jul 2018]. [Accessed 22 Jan. 2019] (online) Available from:
CiplaMed. Tacrolimus [Prescribing Information]. [Last Updated: 17 May 2021]. [Accessed 20 Feb. 2024] (online) Available from:
Everolimus [Prescribing Information]. Berkeley Heights: Hikma Pharmaceuticals USA Inc.; 2023. [Accessed 20 Feb. 2024] (online) Available from:
Everolimus. Bengaluru, India: Biocon Pharma Limited; 2025. [Accessed 02 Oct. 2026] (online). Available from:
Everolimus. New Delhi, India: Aark Pharmaceuticals; [Accessed 02 Oct. 2026] (online). Available from:

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Intas Pharmaceuticals Ltd
Address: Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.

Vendor Details

Country of origin: India

Lab tests offered by us

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Anti Neoplastics

Immunosuppressive Agents

Everotas 0.25 Tablet

Everotas 0.25 Tablet

Product Summary :

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Everotas Tablet

Benefits of Everotas Tablet

Side effects of Everotas Tablet

How to use Everotas Tablet

How Everotas Tablet works

Dosage

All substitutes for Everotas 0.25 Tablet

Advacan 0.25mg Tablet

Evergraf 0.25mg Tablet

Everomus 0.25mg Tablet

CERTIcan 0.25mg Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted) (Injection Route)

Natalizumab (Injection Route)

Cholera Vaccine (Inactivated) (Oral Route)

Purified Vi Polysaccharide Typhoid Vaccine (Injection Route)

Temsirolimus (Injection Route)

Frequently asked questions

Is Everotas 0.25 Tablet a chemotherapy?

How is Everotas 0.25 Tablet administered?

How long can you take Everotas 0.25 Tablet?

What should I avoid while taking Everotas 0.25 Tablet?

What is the most important information I need to know about Everotas 0.25 Tablet?

How will I know that Everotas 0.25 Tablet is shrinking my brain tumor?

Is Everotas 0.25 Tablet cytotoxic?

Is any monitoring required while taking Everotas 0.25 Tablet?

Why might my doctor give me a special mouthwash when I start Everotas 0.25 Tablet?

What should I avoid using if I develop mouth sores?

Can Everotas 0.25 Tablet make me more likely to get infections?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Breast Cancer (CA 15.3/ ER/ PR)

Carcino Embryonic Antigen

Complete Blood Count

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

Related/Popular tests