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Esowell Tablet 40mg

Esomeprazole (40mg)
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Esowell Tablet 40mg is used to treat conditions related to excessive stomach acid production, such as gastroesophageal reflux disease (GERD), peptic ulcer disease, and Zollinger-Ellison syndrome. It reduces the amount of acid produced in the stomach and provides relief from symptoms and promotes healing.

Written By Dr. Anuj Saini, MMST, MBBS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 19 Jan 2026 | 02:50 PM (IST)
₹143 MRP ₹161.211% off 
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General Information

The content is shown in English
Esowell Tablet 40mg image
Esowell Tablet 40mg image

Product introduction

Esowell Tablet 40mg can also be used to prevent stomach ulcers caused by certain medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs). Take it in the exact dose and duration prescribed by your doctor. It is usually taken on an empty stomach, preferably in the morning or at least 1 hour before a meal. Continue taking the medicine even if your symptoms disappear until the doctor says it is okay to stop. If you are taking this medicine for a long time, your doctor may carry out regular tests to check your levels of magnesium, which can fall with this medicine.


Common side effects include headache, constipation or diarrhea, stomach pain, and nausea. These tend to be mild, but talk to your doctor if they bother you or do not go away. The risk of side effects may increase the longer you take this medicine. You may be more likely to have a broken bone if you take it for a long time. It is best to avoid foods that seem to make your symptoms worse, such as rich, spicy, and fatty foods. Cutting down on caffeinated drinks, such as tea, coffee, and cola, as well as alcohol, may also help.


Esowell Tablet 40mg may not be suitable for some people. Before taking this medicine, you need to tell your doctor if you have severe liver problems, are taking medicines for HIV, have had an allergic reaction to similar medicines in the past, or have osteoporosis. Alcohol does not interfere with the way Esowell Tablet 40mg works; however, drinking alcohol makes your stomach produce more acid than normal. This medicine can make you feel dizzy, sleepy, or affect your vision. If this happens, do not drive, cycle, or use machinery or tools until you feel better. This medicine is not usually recommended during pregnancy and breastfeeding.

Uses of Esowell Tablet

Benefits of Esowell Tablet

Acidity
Esowell Tablet 40mg helps relieve the discomfort caused by excessive stomach acid, such as burning sensations, sour stomach, or acid regurgitation. By reducing acid production, it soothes the stomach lining and prevents irritation, providing fast and lasting relief. For individuals suffering from frequent acidity, Esowell Tablet 40mg improves their quality of life by enabling them to enjoy meals and daily activities without the discomfort and inconvenience of acid-related symptoms.
Gastroesophageal reflux disease (Acid reflux)
Esowell Tablet 40mg helps manage GERD by reducing the flow of stomach acid into the esophagus, which causes the burning sensation of heartburn and other acid reflux symptoms. This helps alleviate discomfort, protects the esophagus from long-term damage, and minimizes complications like inflammation or narrowing of the esophagus.
Peptic ulcer disease
In individuals with peptic ulcer disease, Esowell Tablet 40mg helps reduce stomach acid levels, which allows the ulcers to heal more effectively and prevents further damage to the stomach lining. It also helps reduce symptoms like pain, nausea, and indigestion. By promoting healing and preventing the recurrence of ulcers, Esowell Tablet 40mg improves patients’ comfort and restores normal digestion, improving their overall well-being.
Treatment of Zollinger-Ellison syndrome
Zollinger-Ellison syndrome is a rare disorder where excessive stomach acid production can cause severe symptoms like diarrhea, abdominal pain, and ulcers. Esowell Tablet 40mg reduces this overproduction of acid, helping to control symptoms and prevent complications like bleeding ulcers. By managing acid levels effectively, the medicine allows patients to lead a more comfortable and active life without being constantly disrupted by severe digestive symptoms.

Side effects of Esowell Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Esowell
  • Vomiting
  • Nausea
  • Diarrhea
  • Abdominal pain
  • Flatulence
  • Headache
  • Fundic gland polyps

How to use Esowell Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Esowell Tablet 40mg is to be taken on an empty stomach.

How Esowell Tablet works

Esowell Tablet 40mg is a proton pump inhibitor (PPI). It works by reducing the amount of acid in the stomach which helps in relief of acid related indigestion and heartburn.

Quick tips

  • Esowell Tablet 40mg is best taken 1 hour before a meal, preferably in the morning.
  • Avoid drinking alcohol, smoking cigarettes, and excessive intake of carbonated beverages/soft drinks, citrus juices, fried food, and caffeinated beverages like tea and coffee.
  • Inform your doctor if you get watery diarrhea, fever, or stomach pain that does not go away.
  • Inform your doctor if you do not feel better after taking it for 14 days, as you may be suffering from some other problem that needs attention.
  • Long-term use of Esowell Tablet 40mg can cause weak bones and a deficiency of minerals such as magnesium. Take adequate dietary intake of calcium and magnesium or their supplements as prescribed by your doctor.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Esowell Tablet 40mg. Please consult your doctor.
Pregnancy

Pregnancy

SAFE IF PRESCRIBED
Esowell Tablet 40mg is generally considered safe to use during pregnancy. Animal studies do not indicate harmful effects. However, there are limited human studies.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Information regarding the use of Esowell Tablet 40mg during breastfeeding is not available. Please consult your doctor.
Driving

Driving

SAFE
Esowell Tablet 40mg does not usually affect your ability to drive.
Kidney

Kidney

CONSULT YOUR DOCTOR
There is limited data available on the use of Esowell Tablet 40mg in patients with kidney disease. Please consult your doctor.
Liver

Liver

CAUTION
Esowell Tablet 40mg should be used with caution in patients with severe liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Esowell with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Severe

Erlotinib (Oral Route)

Do not consume Erlotinib with Esomeprazole. Esomeprazole may reduce blood levels of Erlotinib.
Severe

Methotrexate (Injection Route)

Please consult with your doctor. Doctor may monitor liver function and blood cell counts.
Severe

Methotrexate (Injection Route)

Please consult with your doctor. Doctor may monitor liver function and blood cell counts.
Severe

Methotrexate (Injection Route)

Please consult with your doctor. Doctor may monitor liver function and blood cell counts.
Severe

Methotrexate (Injection Route)

Please consult with your doctor. Doctor may monitor liver function and blood cell counts.

Frequently asked questions

Usually, Esowell Tablet 40mg is taken once a day, first thing in the morning. If you take Esowell Tablet 40mg twice a day, take 1 dose in the morning and 1 dose in the evening. The tablets should be swallowed whole (remember not be chewed or crushed) and taken at least 1 hour before a meal with some water.
Yes, you can take antacids along with Esowell Tablet 40mg. Take it 2 hours before or after you take Esowell Tablet 40mg.
Esowell Tablet 40mg is usually prescribed for short-term use only. However, if need arises, such as for treating peptic ulcer disease and Zollinger-Ellison syndrome (ZES), Esowell Tablet 40mg may be prescribed for a long-term duration as well. Long-term use may carry an increased risk for side effects and must be discussed with the doctor. Please use Esowell Tablet 40mg as advised by your doctor and under their supervision.
If you have been taking Esowell Tablet 40mg for a long time, stopping it abruptly may lead to increased acid production, thereby worsening your symptoms. Therefore, you must discuss any dose changes or if you wish to come off Esowell Tablet 40mg.
If Esowell Tablet 40mg is used for more than 3 months, certain long-term side effects may be seen. The most important of these is low magnesium levels in your blood, which may make you feel tired, confused, dizzy, or shaky. You may also have muscle twitches or an irregular heartbeat. If the use is further prolonged for more than a year, you may have an increased risk of bone fractures, stomach infections, and vitamin B12 deficiency. Vitamin B12 deficiency can make you anemic, as a result of which you may feel more tired, weak, or pale. Additionally, you may have palpitations, shortness of breath, lightheadedness, indigestion, loss of appetite, flatulence (gas), or nerve problems such as numbness, tingling, and problem in walking.
No, alcohol intake is not advised with Esowell Tablet 40mg. Alcohol itself does not affect the working of Esowell Tablet 40mg, but it can increase the acid production. This may further cause worsening of your symptoms.

Fact Box

Chemical Class

Sulfinylbenzimidazoles

Habit Forming

No

Therapeutic Class

GASTRO INTESTINAL

Action Class

Proton-Pump Inhibitors
Related ayurvedic ingredients
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Boeing Pharma Pvt Ltd
Address: I-1,302 Global City ,Virar(W), Maharashtra,401303

Vendor Details

Country of origin: India
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