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Esentra 60mg Injection

Denosumab (60mg)

Genuine

Authenticity Assured

Prescription

required

Cold stored

Stored between 2-8°C

Product Summary :

Esentra 60mg Injection is a monoclonal antibody containing denosumab used to treat osteoporosis in postmenopausal women and men at increased risk of fractures. It helps slow down bone breakdown, making bones stronger and reducing the risk of fractures. It is given as an injection under the skin once every 6 months. The doctor may advise calcium and vitamin D supplements during treatment. Common side effects include back pain, pain in the arms or legs, and muscle or bone pain. Do not stop or delay treatment without consulting your doctor, as this may increase the risk of fractures. Tell your doctor if you have kidney disease, especially if you are on dialysis, as Esentra 60mg Injection can cause severely low blood calcium levels.

Written By Dr. Syeda Aafia, MBA, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 24 Sep 2026 | 01:04 AM (IST)

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Denosumab (60mg)

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General Information

Contains

Denosumab (60mg)

Marketer

Intas Pharmaceuticals Ltd

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.

The content is shown in English

Product introduction

Esentra 60mg Injection is used to treat osteoporosis in postmenopausal women and men at increased risk of fractures. It is also used to manage bone loss associated with long-term glucocorticoid treatment. It works by slowing down bone breakdown, which helps increase bone strength and reduce the risk of fractures.

Esentra 60mg Injection is given as an injection under the skin once every 6 months. Your doctor may advise you to take adequate calcium and vitamin D during treatment. Do not delay or stop treatment without consulting your doctor, as stopping the treatment can increase the risk of fractures. If treatment is discontinued, your doctor may recommend another medicine to prevent bone loss.

Common side effects of Esentra 60mg Injection include back pain, pain in the arms or legs, joint pain, and muscle or bone pain. Tell your doctor if these symptoms become severe or do not go away. They may be able to suggest ways to manage or treat the side effects.

Esentra 60mg Injection can cause low calcium levels in the blood. Your doctor may check your calcium and other mineral levels before and during treatment. Inform your doctor you have kidney problems or are on dialysis. Esentra 60mg Injection should not be used during pregnancy as it may harm the unborn baby. Women of reproductive age should use effective contraception during treatment and for at least 5 months after the last dose.

Uses of Esentra Injection

Treatment of Osteoporosis : Helps slow down bone breakdown, making bones stronger and reducing the risk of fractures in postmenopausal women and men at increased risk of fractures.

Benefits of Esentra Injection

Treatment of Osteoporosis
Osteoporosis is a condition in which the bones become weak and are more likely to break. Esentra 60mg Injection is used to treat osteoporosis in postmenopausal women and men at increased risk of fractures and can also help manage bone loss associated with long-term glucocorticoid treatment. It slows down bone breakdown and increases bone strength and density. This helps reduce the risk of fractures, including fractures of the spine, hip, and other bones.

Side effects of Esentra Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Esentra

Back pain
Pain in extremities
Hypercholesterolemia (high cholesterol)
Musculoskeletal (bone, muscle or joint) pain
Cystitis
Pancreatic inflammation
Joint pain
Nasopharyngitis (inflammation of the throat and nasal passages)
High blood pressure
Bronchitis (inflammation of the airways)
Headache

How to use Esentra Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Esentra Injection works

Esentra 60mg Injection is a monoclonal antibody that works by blocking a protein called RANKL, which is involved in the formation and activity of cells called osteoclasts that break down bone. Blocking RANKL reduces the formation and activity of these bone-breaking cells. This slows bone loss, increases bone mass, and helps make bones stronger.

Dosage

Esentra 60mg Injection is given as an injection under the skin once every 6 months, usually in the upper arm, thigh, or abdomen. The duration of treatment will depend on your condition and response to treatment. Your doctor will periodically assess whether you need to continue it. Adequate calcium and vitamin D should be taken during treatment as advised by your doctor. Do not stop or delay treatment without consulting your doctor.

All substitutes for Esentra 60mg Injection

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Take calcium and vitamin D supplements as advised by your doctor to help maintain normal calcium levels during treatment.
Do not stop Esentra 60mg Injection without talking to your doctor. Stopping or delaying treatment may increase the risk of fractures, including multiple fractures of the spine. If treatment is stopped, your doctor may prescribe another medicine to prevent bone loss.
Tell your doctor if you have kidney disease or are on dialysis. Advanced kidney disease significantly increases the risk of severe low calcium levels, and close monitoring may be required.
Maintain good oral and dental hygiene and have regular dental checkups. Tell your dentist that you are receiving Esentra 60mg Injection before undergoing dental procedures.
Contact your doctor if you develop new or unusual pain in your thigh, hip, or groin, as this may be an early sign of an unusual thigh-bone fracture.
Seek medical attention if you develop symptoms of low calcium, such as muscle spasms or cramps, tingling or numbness around the mouth or in the fingers or toes.
Do not use Esentra 60mg Injection during pregnancy. Women who can become pregnant should use effective contraception during treatment and for at least 5 months after the last dose.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Esentra 60mg Injection. Please consult your doctor.

Pregnancy

UNSAFE

Esentra 60mg Injection is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.

Breast feeding

CAUTION

Esentra 60mg Injection should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.

Driving

SAFE

Esentra 60mg Injection does not usually affect your ability to drive.

Kidney

SAFE IF PRESCRIBED

Esentra 60mg Injection is safe to use in patients with kidney disease. No dose adjustment is recommended.
However, patients with advanced kidney disease, especially those on dialysis, have an increased risk of severe low blood calcium levels (hypocalcemia). Close monitoring of calcium levels is recommended.

Liver

CONSULT YOUR DOCTOR

There is limited data available on the use of Esentra 60mg Injection in patients with liver disease.

Interaction with drugs

Taking Esentra with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Cinacalcet (Oral Route)

Your doctor may monitor your treatment and adjust the doses as per the observations. Denosumab may increase the metabolism of Cinacalcet.

Frequently asked questions

How long can you stay on Esentra 60mg Injection?

The duration of treatment with Esentra 60mg Injection depends on your condition and your risk of fractures. Your doctor will periodically assess whether you should continue treatment. Do not stop or delay treatment on your own, because stopping denosumab can increase the risk of fractures, including multiple fractures of the spine.

Is Esentra 60mg Injection a chemotherapy drug?

No. Esentra 60mg Injection is not a chemotherapy medicine. It is a monoclonal antibody that blocks RANKL, a protein involved in the formation and activity of cells that break down bone. This helps reduce bone loss and increase bone strength.

How is Esentra 60mg Injection given and how often?

Esentra 60mg Injection is given as an injection under the skin by a doctor or a nurse. For osteoporosis and related bone-loss conditions, the recommended dose once every 6 months. Your doctor may also advise adequate calcium and vitamin D supplementation.

Can Esentra 60mg Injection be taken during pregnancy?

No. Esentra 60mg Injection should not be used during pregnancy because it may harm the unborn baby. Women who can become pregnant should use effective contraception during treatment and for at least 5 months after the last dose.

Can people with kidney disease use Esentra 60mg Injection?

Yes, people with kidney disease can use Esentra 60mg Injection. However, people with advanced chronic kidney disease, especially those on dialysis, have a much greater risk of severe low calcium levels after receiving Esentra 60mg Injection. Your doctor may perform additional blood tests and monitor your calcium levels closely before and after treatment.

Why should I not stop Esentra 60mg Injection on my own?

Stopping or delaying Esentra 60mg Injection can cause bone breakdown to increase again and may raise the risk of fractures. Multiple fractures of the spine can occur after discontinuing the medicine. If treatment needs to be stopped, your doctor may switch you to another medicine to reduce this risk.

Does Esentra 60mg Injection cause osteonecrosis of the jaw?

Osteonecrosis of the jaw is an uncommon but serious problem reported with Esentra 60mg Injection. Maintain good oral hygiene and have regular dental checkups during treatment. Tell your doctor and dentist if you develop persistent jaw pain or swelling, loose teeth, or sores in the mouth that do not heal, and inform your dentist that you are receiving Esentra 60mg Injection before dental procedures.

Fact Box

Chemical Class

Peptides

Habit Forming

Therapeutic Class

PAIN ANALGESICS

Action Class

RANKL Inhibitor – Monoclonal Antibody

Related lab tests

Calcium

References

Bikle DD. Agents That Affects Bone Mineral Homoestasis. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 766.
Friedman PA. Agents Affecting Mineral Ion Homeostasis and Bone Turnover. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1299.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 370.
Denosumab [Prescribing Information]. Thousand Oaks, CA: Amgen Inc.; 2026. [Accessed 22 Sept. 2026] (online) Available from:
Denosumab [Prescribing Information]. Mumbai, India: Alkem Laboratories Ltd.; 2026. [Accessed 22 Sept. 2026] (online) Available from:
Denosumab [EMC SmPC]. Milton Road, Cambridge: Amgen Ltd.; 2018. [Accessed 02 Apr. 2019] (online) Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Intas Pharmaceuticals Ltd
Address: Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

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Pain Analgesics

Medicines For Osteoporosis

Esentra 60mg Injection

Esentra 60mg Injection

Product Summary :

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Esentra Injection

Benefits of Esentra Injection

Side effects of Esentra Injection

How to use Esentra Injection

How Esentra Injection works

Dosage

All substitutes for Esentra 60mg Injection

Denuril Injection

Denub 60mg Injection

Supdeno Injection

Deninta SC Injection

Denoclast Injection

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Cinacalcet (Oral Route)

Frequently asked questions

How long can you stay on Esentra 60mg Injection?

Is Esentra 60mg Injection a chemotherapy drug?

How is Esentra 60mg Injection given and how often?

Can Esentra 60mg Injection be taken during pregnancy?

Can people with kidney disease use Esentra 60mg Injection?

Why should I not stop Esentra 60mg Injection on my own?

Does Esentra 60mg Injection cause osteonecrosis of the jaw?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Calcium

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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