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Denuril Injection

Denosumab (60mg)

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Cold stored

Stored between 2-8°C

Denuril Injection is a medicine used in the treatment of osteoporosis in postmenopausal women and in men at increased risk of fractures. It makes the bones strong and reduce the risk of fractures.

Written By Dr. Syeda Aafia, MBA, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 06 Apr 2026 | 04:05 PM (IST)

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1 ml Injection

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General Information

Contains

Denosumab (60mg)

Marketer

Alkem Laboratories Ltd

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.

The content is shown in English

Product introduction

Denuril Injection is given by a healthcare professional and should not be self-administered. You should use it regularly and at the same time each day to get maximum benefit from it. Continue using it as recommended by your doctor and complete the dose even if you feel better. To make it more effective, take adequate amount of calcium and vitamin D supplements while on treatment with this medicine.

Some common side effects of this medicine include headache, pain in extremity, musculoskeletal pain, nerve pain, constipation, and rash. Talk to your doctor if any of these side effects does not go away with time or get worse. Your doctor may help with ways to reduce or prevent these symptoms.

To make sure the medicine is safe for you, before taking it, let your doctor know of all the other medicines you are taking. It is important for pregnant and breastfeeding mothers to ask the advice of their doctors before using this medicine.

Uses of Denuril Injection

Osteoporosis

Benefits of Denuril Injection

Osteoporosis
Osteoporosis is a condition where bones become weak and brittle, making them more prone to fractures even with minor falls or injuries. Denuril Injection helps slow down bone breakdown and increases bone density, reducing the risk of fractures in the spine, hip, and other bones. This supports stronger, healthier bones and improves overall bone strength.

Side effects of Denuril Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Denuril

Rash
Musculoskeletal (bone, muscle or joint) pain
Eczema
Upper respiratory tract infection
Sciatica
Pain in extremities
Back pain
Joint pain
Urinary tract infection
Constipation
Abdominal discomfort
Hair loss
Hypercholesterolemia (high cholesterol)
Cystitis
Nerve pain
Headache

How to use Denuril Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Denuril Injection works

Denuril Injection is a monoclonal antibody. It binds to a protein that causes bone loss, thereby strengthening the bone and minimizing the risk of fractures.

All substitutes for Denuril Injection

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Denuril Injection is a medication used to treat thinning of the bones (called osteoporosis).
Take calcium and vitamin D to help build your bones when taking Denuril Injection.
Do not take if you are pregnant or plan to become pregnant.
May cause a rare problem of the jaw (osteonecrosis), mostly seen after a dental procedure. Tell your doctor if you develop sudden jaw pain.
Denuril Injection may also increase the risk of infection. Avoid being close to people with cold, flu or other contagious illnesses.
Tell your doctor if you develop a rash while taking Denuril Injection.
Denuril Injection is a medication used to treat thinning of the bones (called osteoporosis).
Take calcium and vitamin D to help build your bones when taking Denuril Injection.
Do not take if you are pregnant or plan to become pregnant.
May cause a rare problem of the jaw (osteonecrosis), mostly seen after a dental procedure. Tell your doctor if you develop sudden jaw pain.
Denuril Injection may also increase the risk of infection. Avoid being close to people with cold, flu or other contagious illnesses.
Tell your doctor if you develop a rash while taking Denuril Injection.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Denuril Injection. Please consult your doctor.

Pregnancy

UNSAFE

Denuril Injection is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.

Breast feeding

CAUTION

Denuril Injection should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.

Driving

CONSULT YOUR DOCTOR

It is not known whether Denuril Injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.

Kidney

SAFE IF PRESCRIBED

Denuril Injection is probably safe to use in patients with kidney disease. Limited data suggest dose adjustment may not be needed.

Liver

SAFE IF PRESCRIBED

Denuril Injection is probably safe to use in patients with liver disease. Limited data suggest dose adjustment may not be needed.

Interaction with drugs

Taking Denuril with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Cinacalcet (Oral Route)

Your doctor may monitor your treatment and adjust the doses as per the observations. Denosumab may increase the metabolism of Cinacalcet.

Frequently asked questions

How long can you stay on Denuril Injection?

There is no optimal duration of treatment of osteoporosis with Denuril Injection. The patient’s response and tolerability to the medicine is continuously monitored through periodic assessments, especially after 5 years of use of Denuril Injection. Depending on this, the duration of taking Denuril Injection is decided.

Does Denuril Injection cause hair loss?

Yes, hair loss is a common side effect of Denuril Injection though it does not affect everyone. Discuss with your doctor if you have concerns regarding your hair loss.

Is Denuril Injection a chemotherapy drug?

Denuril Injection is not a chemotherapy drug. It is a protein (monoclonal antibody) that interferes with the action of another protein in order to treat bone loss and osteoporosis. Treatment with Denuril Injection makes the bones stronger and less likely to break.

How is Denuril Injection given and how often?

Denuril Injection is available as an injection and is given by a healthcare professional. It is given once in 6 months. Your doctor may also advise you to take calcium and vitamin D while taking Denuril Injection.

Can Denuril Injection be taken during pregnancy?

No, pregnant women should not take Denuril Injection. You must use an effective method of birth control during and for at least 5 months after the last dose of Denuril Injection if you can become pregnant.

How should Denuril Injection be stored?

Denuril Injection should be stored in a refrigerator at 36°F to 46°F (2°C to 8°C) in the original carton. Warm temperatures can make it ineffective, and therefore proper storage is necessary. When you remove it from the refrigerator, keep it at room temperature [up to 77°F (25°C)] in the original carton and use it within 14 days.

Does Denuril Injection cause osteonecrosis of the jaw?

Osteonecrosis is a rare side effect of Denuril Injection. It refers to the damage caused to the bone of jaw. To avoid this, you should maintain good oral hygiene and receive routine dental check ups while taking Denuril Injection. Contact your doctor and dentist immediately if you experience any problems with your mouth or teeth such as loose teeth, discharge, pain or swelling, or non-healing of sores. These could be signs of osteonecrosis of jaw.

How long can you stay on Denuril Injection?

Does Denuril Injection cause hair loss?

Yes, hair loss is a common side effect of Denuril Injection though it does not affect everyone. Discuss with your doctor if you have concerns regarding your hair loss.

Is Denuril Injection a chemotherapy drug?

How is Denuril Injection given and how often?

Can Denuril Injection be taken during pregnancy?

How should Denuril Injection be stored?

Does Denuril Injection cause osteonecrosis of the jaw?

Fact Box

Chemical Class

Peptides

Habit Forming

Therapeutic Class

PAIN ANALGESICS

Action Class

Bone Resorption Inhibitors- Monoclonal Antibodies

Related lab tests

Calcium

References

Bikle DD. Agents That Affects Bone Mineral Homoestasis. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 766.
Friedman PA. Agents Affecting Mineral Ion Homeostasis and Bone Turnover. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1299.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 370.
Denosumab. Milton Road, Cambridge: Amgen Ltd.; 2010 [revised Jun. 2018]. [Accessed 02 Apr. 2019] (online) Available from:
Denosumab [Prescribing Information]. Thousand Oaks, California: Amgen Manufacturing Limited; 2013. [Accessed 20 Feb. 2024] (online) Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Alkem Laboratories Ltd
Address: Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Denuril Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

Lab tests offered by us

Why we need a prescription?

Denuril Injection

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Denuril Injection

Benefits of Denuril Injection

Side effects of Denuril Injection

How to use Denuril Injection

How Denuril Injection works

All substitutes for Denuril Injection

Denub 60mg Injection

Denoclast Injection

Deninta SC Injection

Supdeno Injection

Esentra 60mg Injection

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Cinacalcet (Oral Route)

Frequently asked questions

How long can you stay on Denuril Injection?

Does Denuril Injection cause hair loss?

Is Denuril Injection a chemotherapy drug?

How is Denuril Injection given and how often?

Can Denuril Injection be taken during pregnancy?

How should Denuril Injection be stored?

Does Denuril Injection cause osteonecrosis of the jaw?

How long can you stay on Denuril Injection?

Does Denuril Injection cause hair loss?

Is Denuril Injection a chemotherapy drug?

How is Denuril Injection given and how often?

Can Denuril Injection be taken during pregnancy?

How should Denuril Injection be stored?

Does Denuril Injection cause osteonecrosis of the jaw?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Calcium

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

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