Endoprost 125mcg Injection

Carboprost (125mcg)

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Cold stored

Stored between 2-8°C

Endoprost 125mcg Injection is a medicine used to control excessive bleeding after childbirth (postpartum hemorrhage), particularly when the uterus does not contract properly. It works by stimulating uterine contractions, which help reduce blood loss after delivery.

Written By Dr. Anuj Saini, MMST, MBBS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 04 Nov 2026 | 01:03 AM (IST)

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General Information

Contains

Carboprost (125mcg)

Marketer

Bharat Serums & Vaccines Ltd

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.

The content is shown in English

Product introduction

Endoprost 125mcg Injection is given as a deep intramuscular injection by a healthcare professional in a hospital or clinical setting. It is generally used when excessive bleeding after childbirth has not responded to conventional treatments. Your doctor will determine whether additional doses are needed based on your response to treatment.

Common side effects of Endoprost 125mcg Injection include vomiting, diarrhea, flushing, and fever. Inform your doctor if any side effects become severe or cause concern. There may be ways of reducing or preventing them.

Before receiving Endoprost 125mcg Injection, inform your doctor if you have asthma, heart disease, high or low blood pressure, or liver or kidney problems. Also, tell your doctor about any other medicines you are taking, particularly medicines that stimulate uterine contractions, as their effects may be increased. This medicine is intended for use after childbirth and should not be used during pregnancy.

Uses of Endoprost Injection

Treatment of Post-delivery bleeding

Benefits of Endoprost Injection

Treatment of Post-delivery bleeding
After childbirth, some women may experience heavy bleeding due to the uterus not contracting properly. Endoprost 125mcg Injection is used to control this bleeding by helping the uterus contract more effectively. This reduces blood loss and supports a safer recovery after delivery.

Side effects of Endoprost Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Endoprost

Vomiting
Diarrhea
Fever
Flushing (sense of warmth in the face, ears, neck and trunk)

How to use Endoprost Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Endoprost Injection works

Endoprost 125mcg Injection is a synthetic prostaglandin F2α analogue that stimulates strong contractions of the uterus after childbirth. These contractions help compress the blood vessels at the site where the placenta was attached, thereby controlling excessive bleeding (postpartum hemorrhage/post-delivery bleeding).

Quick tips

Endoprost 125mcg Injection is used to control excessive bleeding after childbirth, particularly when the uterus fails to contract properly, and other treatments have not worked.
Your doctor may administer additional doses if the bleeding does not stop after the first injection.
Inform your doctor if you have a history of asthma, heart disease, high or low blood pressure, or liver or kidney problems before receiving this medicine.
Tell your doctor if you are taking other medicines that stimulate uterine contractions, as their effects may be increased when used with Endoprost 125mcg Injection.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Endoprost 125mcg Injection. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Endoprost 125mcg Injection is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Endoprost 125mcg Injection during breastfeeding is not available. Please consult your doctor.

Driving

NOT RELEVANT

Not relevant, as Endoprost 125mcg Injection is intended for use in hospitalized patients.

Kidney

UNSAFE

Endoprost 125mcg Injection is unsafe to use in patients with kidney disease and should be avoided.

Liver

UNSAFE

Endoprost 125mcg Injection is unsafe to use in patients with liver disease and should be avoided.

Frequently asked questions

What is Endoprost 125mcg Injection used for?

Endoprost 125mcg Injection is used to control excessive bleeding after childbirth, also known as postpartum hemorrhage. It is particularly useful when the uterus does not contract properly after delivery, a condition called uterine atony. It is generally given when conventional treatments have not adequately controlled the bleeding.

How does Endoprost 125mcg Injection help control bleeding after childbirth?

Endoprost 125mcg Injection works by stimulating the muscles of the uterus to contract strongly after childbirth. These contractions help compress the blood vessels at the site where the placenta was attached. This helps reduce blood loss and control postpartum hemorrhage.

How is Endoprost 125mcg Injection administered?

Endoprost 125mcg Injection is administered as a deep intramuscular injection by a trained healthcare professional. It is given in a hospital or specialised medical setting where the patient's condition can be closely monitored. It must not be administered intravenously.

How quickly does Endoprost 125mcg Injection work to control postpartum bleeding?

Endoprost 125mcg Injection stimulates uterine contractions after administration, helping to control excessive bleeding. The response may vary depending on the severity of bleeding and the patient's condition. Your doctor will monitor the bleeding and determine whether additional doses are necessary.

Can Endoprost 125mcg Injection be given more than once if bleeding continues?

Yes, your doctor may administer additional doses of Endoprost 125mcg Injection if the bleeding is not adequately controlled after the first injection. The timing and number of injections depend on your response to treatment and the severity of bleeding. The total dose should not exceed the maximum recommended in the prescribing information.

Is Endoprost 125mcg Injection safe for women with asthma?

Endoprost 125mcg Injection should be used with caution in women who have asthma or a history of breathing problems. It may cause narrowing of the airways, which can lead to breathing difficulties in some patients. Inform your doctor about any history of asthma or respiratory problems before receiving this medicine.

Can Endoprost 125mcg Injection be used during pregnancy?

Endoprost 125mcg Injection is intended to control excessive bleeding after childbirth and should not be used during an ongoing pregnancy for this indication. It stimulates strong uterine contractions, which may pose serious risks to the developing baby. Your doctor will administer this medicine only when it is appropriate for your condition.

Can Endoprost 125mcg Injection be used along with other medicines to control postpartum bleeding?

Endoprost 125mcg Injection may increase the effects of other medicines that stimulate uterine contractions, such as oxytocin. Therefore, using these medicines together is generally not recommended without careful medical supervision. Your doctor will decide the appropriate treatment based on your condition and response to previously administered medicines.

Fact Box

Chemical Class

Prostaglandin derivative

Habit Forming

Therapeutic Class

GYNAECOLOGICAL

Action Class

Methyl-PGF2α Analogue

Related lab tests

Activated Partial Thromboplastin Time

Complete Blood Count

Prothrombin Time

Thrombin Time

References

Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 208-209.
Carboprost [EMC SmPC]. Sandwich, Kent: Pfizer Limited; 2022. [Accessed 03 Nov. 2026] (online) Available from:
Carboprost [New Zealand Data Sheet]. Auckland, New Zealand: Pfizer New Zealand Limited; 2019. [Accessed 03 Nov. 2026] (online) Available from:
Carboprost Tromethamine Injection I.P. [Product Information]. Ambernath, Maharashtra: Bharat Serums and Vaccines Limited; 2015. [Accessed 03 Nov. 2026] (online) Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Bharat Serums & Vaccines Ltd
Address: 17th Floor, Hoechst House, Nariman Point, Mumbai – 400 021, Maharashtra, India.

Vendor Details

Country of origin: India

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Endoprost 125mcg Injection

Endoprost 125mcg Injection

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Endoprost Injection

Benefits of Endoprost Injection

Side effects of Endoprost Injection

How to use Endoprost Injection

How Endoprost Injection works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Frequently asked questions

What is Endoprost 125mcg Injection used for?

How does Endoprost 125mcg Injection help control bleeding after childbirth?

How is Endoprost 125mcg Injection administered?

How quickly does Endoprost 125mcg Injection work to control postpartum bleeding?

Can Endoprost 125mcg Injection be given more than once if bleeding continues?

Is Endoprost 125mcg Injection safe for women with asthma?

Can Endoprost 125mcg Injection be used during pregnancy?

Can Endoprost 125mcg Injection be used along with other medicines to control postpartum bleeding?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Activated Partial Thromboplastin Time

Complete Blood Count

Prothrombin Time

Thrombin Time

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

Related/Popular tests