Difen Patch

Diclofenac (200mg)

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required

Difen Patch is a pain relieving medicine. It is used to treat pain, swelling, stiffness and joint pain in conditions like rheumatoid arthritis, osteoarthritis and acute musculoskeletal injuries. It is commonly used in back pain, shoulder pain, neck pain, sprains and spasms.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 16 Apr 2026 | 11:41 AM (IST)

₹91.1 MRP ₹103.1312% off

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Difen Patch is currently sold out

Same composition alternative:

Zeldinac Transdermal Patch

₹89.5~~₹140.63~~

67% cheaper alternative available

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Difen Patch

packet of 1 Transdermal Patch

₹91.1

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Same composition

Zeldinac Transdermal Patch

box of 3 transdermal patches

Diclofenac (200mg)

by Leeford Healthcare Ltd

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General Information

Contains

Diclofenac (200mg)

Marketer

Emris India Private Limited

Storage

Store below 25°C

The content is shown in English

Product introduction

Your doctor will explain how to use Difen Patch. Follow the instructions carefully to get the most benefit. The dose and duration will depend on what you are using it for and how well it helps your symptoms. Use it regularly and do not discontinue using it until the doctor tells you to stop using it.

The most common side effect of this medicine is application site reactions such as burning, irritation, itching, and redness. You may have these side effects more often when you start your treatment or when your dose is increased. Usually, the side effects will slowly go away as your body gets used to it. If they are severe or do not go away, you should remove your patch and contact your doctor.

Before using the medicine, you should tell your doctor if you have any other illnesses or disorders. It may also affect, or be affected by some other medicines you are using. Let your doctor know all the other medicines you are taking or using to make sure it is safe for you. Pregnant and breastfeeding women should consult their doctors first before using the medicine.

Uses of Difen Transdermal Patch

Pain relief

Benefits of Difen Transdermal Patch

Pain relief
Difen Patch belongs to a group of medicines called nonsteroidal anti-inflammatory drugs (NSAIDs). It is used for short-term relief of pain, inflammation, and swelling in conditions that affect joints and muscles. It works by blocking chemical messengers in the brain that tell us we have pain. It can help relieve pain in conditions like rheumatoid arthritis and osteoarthritis.

Take it as it is prescribed to get the most benefit. Do not take more or longer than needed as that can be dangerous. In general, you should take the lowest dose that works, for the shortest possible time. This will help you to go about your daily activities more easily and have a better, more active, quality of life.

Side effects of Difen Transdermal Patch

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Difen

Application site reactions (burning, irritation, itching and redness)

How to use Difen Transdermal Patch

Use this medicine in dose and duration as advised by your doctor. Check the label before use. Make sure the skin is clean and dry. Remove the protective liner of the patch. Do not touch the sticky side. With sticky side down, place the patch evenly onto the skin.

How Difen Transdermal Patch works

Difen Patch belongs to a class of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). It works by blocking the release of certain chemical messengers that cause pain and inflammation (redness and swelling).

All substitutes for Difen Patch

For information purposes only. Consult a doctor before taking any medicine.

Zeldinac Transdermal Patch

by Leeford Healthcare Ltd

₹29.83/transdermal patch

67% cheaper

Quick tips

Use the Difen Patch only on clean, dry, and intact skin; avoid applying it to cuts, wounds, or irritated areas.
Wash your hands after handling it and avoid contact with your eyes, nose, or mouth.
If skin irritation, redness, or rash occurs at the application site, consult a doctor.
Avoid using other NSAIDs simultaneously unless prescribed, as it may increase the risk of side effects.
Inform your doctor if you have a history of heart, kidney, or gastrointestinal issues before use.

Safety advice

Alcohol

No interaction found/established

Pregnancy

CONSULT YOUR DOCTOR

The safety of Difen Patch during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Avoid use of Difen Patch in pregnant women starting at 30 weeks gestation.

Breast feeding

CAUTION

Difen Patch should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.

Driving

No interaction found/established

Kidney

CAUTION

Difen Patch should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

CAUTION

Difen Patch should be used with caution in patients with liver disease. Dose adjustment may be needed.
Regular monitoring of liver function tests is recommended in patients with liver disease if this medicine is to be taken for a long time.

Interaction with drugs

Taking Difen with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Tacrolimus (Oral Route)

If concurrent use is essential, your doctor may monitor your tacrolimus levels, potassium levels and kidney function closely. They may adjust the doses as per the observations.

Severe

Methotrexate (Injection Route)

Please consult with your doctor. Doctor may monitor liver function and blood cell counts.

Severe

Methotrexate (Injection Route)

Please consult with your doctor. Doctor may monitor liver function and blood cell counts.

Severe

Methotrexate (Injection Route)

Please consult with your doctor. Doctor may monitor liver function and blood cell counts.

Severe

Methotrexate (Injection Route)

Please consult with your doctor. Doctor may monitor liver function and blood cell counts.

Frequently asked questions

What is Difen Patch used for?

Difen Patch is used to relieve mild to moderate pain caused by minor sprains, strains, and bruises. It works by reducing inflammation directly at the site of application.

How does the Difen Patch work?

Difen Patch delivers diclofenac, an NSAID, through the skin directly to the painful area. It blocks substances in the body that cause inflammation and pain.

Is Difen Patch safer than oral NSAIDs?

While Difen Patch may cause fewer stomach-related side effects than oral NSAIDs, it still carries risks like heart problems, kidney damage, and liver toxicity, especially if overused or used with other NSAIDs.

What are the serious side effects of Difen Patch?

The serious side effects of Difen Patch include heart attack, stroke, liver damage, kidney problems, and serious skin reactions. You should stop using Difen Patch and seek medical help if you notice chest pain, yellowing of the skin, or trouble breathing.

Who should not use the Difen Patch?

Individuals should not use Difen Patch if they are allergic to NSAIDs, have asthma triggered by aspirin, are recovering from heart surgery, or have damaged or infected skin at the application site.

How should I apply the Difen Patch?

Application Steps: Clean and dry the affected area thoroughly. Remove the patch from its packaging, peel off the protective liner, place the adhesive side directly onto the skin over the painful area, and press firmly to ensure full contact, especially around the edges. Precautions: Avoid applying the patch to damaged or irritated skin. Do not use external heat sources, such as heating pads, over the patch, as this can increase drug absorption and risk of side effects.

What should I do if I get a rash or reaction on the skin after using Difen Patch?

If you notice redness, rash, or peeling at the Difen Patch application site, remove it immediately and wash the area. If the reaction spreads or worsens, seek medical attention.

Can I shower or swim while wearing the Difen Patch?

No, you should not shower, bathe, or swim while wearing the Difen Patch. Water can affect how the medication is absorbed and may cause the Difen Patch to peel off.

How long does it take for the Difen Patch to work?

The exact time Difen Patch takes to work is not known. However, you may notice reduced pain in 1 to 2 days.

Fact Box

Chemical Class

Dichlorobenzenes

Habit Forming

Therapeutic Class

PAIN ANALGESICS

Action Class

NSAID's- Non-Selective COX 1&2 Inhibitors (acetic acid)

References

Furst DE, Ulrich RW, Varkey-Altamirano C. Nonsteroidal Anti-Inflammatory Drugs, Disease Modifying Antirheumatic Drugs, Nonopioids Analgesics, & Drugs Used in Gout. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 626.
Grosser T, Smyth E, FitzGerald GA. Anti-Inflammatory, Antipyretic, and Analgesic Agents; Pharmacotherapy of Gout. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 986-87.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 295-97.
Diclofenac epolamine patch [FDA Label]. Kagawa, Japan: Teikoku Seiyaku Co., Ltd.; 2018. [Accessed Dec. 01 Dec. 2020]. (online) Available from:
Diclofenac epolamine patch [Prescribing Information]. New York, NY: Pfizer Inc.; 2018. [Accessed 06 Apr. 2024] (online) Available from:
Diclofenac Diethylamine. Mumbai, Maharashtra: Zuventus Healthcare Ltd.; [Accessed 16 Apr. 2026] (online). Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Emris India Private Limited
Address: "Hnom-22f/f, Nr Khaliullah, Masjid, Batla House Okhla, Zakir Nagar, South Delhi, New Delhi, Delhi, India, 110025"

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Difen Patch

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Difen Transdermal Patch

Benefits of Difen Transdermal Patch

Side effects of Difen Transdermal Patch

How to use Difen Transdermal Patch

How Difen Transdermal Patch works

All substitutes for Difen Patch

Zeldinac Transdermal Patch

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Tacrolimus (Oral Route)

Methotrexate (Injection Route)

Methotrexate (Injection Route)

Methotrexate (Injection Route)

Methotrexate (Injection Route)

Frequently asked questions

What is Difen Patch used for?

How does the Difen Patch work?

Is Difen Patch safer than oral NSAIDs?

What are the serious side effects of Difen Patch?

Who should not use the Difen Patch?

How should I apply the Difen Patch?

What should I do if I get a rash or reaction on the skin after using Difen Patch?

Can I shower or swim while wearing the Difen Patch?

How long does it take for the Difen Patch to work?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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