Denorange Injection

Denosumab (60mg/ml)

Genuine

Authenticity Assured

Prescription

required

Cold stored

Stored between 2-8°C

Denorange Injection is a medicine used in the treatment of osteoporosis in postmenopausal women and in men at increased risk of fractures. It makes the bones strong and reduce the risk of fractures.

Written By Dr. Syeda Aafia, MBA, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 25 Nov 2025 | 03:05 PM (IST)

₹17778 MRP ₹19687.510% off

Gurgaon

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Denorange Injection

prefilled syringe of 1 ml Injection

₹17778

~~₹19687.5~~

Same composition

Odensomab Injection

prefilled syringe of 1 Injection

Denosumab (60mg/ml)

by Lupin Ltd

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General Information

Contains

Denosumab (60mg/ml)

Marketer

Biorange Biologicals Private Limited

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.

The content is shown in English

Product introduction

Denorange Injection is given by a healthcare professional and should not be self-administered. You should use it regularly and at the same time each day to get maximum benefit from it. Continue using it as recommended by your doctor and complete the dose even if you feel better. To make it more effective, take adequate amount of calcium and vitamin D supplements while on treatment with this medicine.

Some common side effects of this medicine include headache, pain in extremity, musculoskeletal pain, nerve pain, constipation, and rash. Talk to your doctor if any of these side effects does not go away with time or get worse. Your doctor may help with ways to reduce or prevent these symptoms.

To make sure the medicine is safe for you, before taking it, let your doctor know of all the other medicines you are taking. It is important for pregnant and breastfeeding mothers to ask the advice of their doctors before using this medicine.

Uses of Denorange Injection

Osteoporosis

Benefits of Denorange Injection

Osteoporosis
Osteoporosis is a condition where bones become weak and brittle, making them more prone to fractures even with minor falls or injuries. Denorange Injection helps slow down bone breakdown and increases bone density, reducing the risk of fractures in the spine, hip, and other bones. This supports stronger, healthier bones and improves overall bone strength.

Side effects of Denorange Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Denorange

Rash
Musculoskeletal (bone, muscle or joint) pain
Eczema
Upper respiratory tract infection
Sciatica
Pain in extremities
Back pain
Joint pain
Urinary tract infection
Constipation
Abdominal discomfort
Hair loss
Hypercholesterolemia (high cholesterol)
Cystitis
Nerve pain
Headache

How to use Denorange Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Denorange Injection works

Denorange Injection is a monoclonal antibody. It binds to a protein that causes bone loss, thereby strengthening the bone and minimizing the risk of fractures.

All substitutes for Denorange Injection

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Denorange Injection is a medication used to treat thinning of the bones (called osteoporosis).
Take calcium and vitamin D to help build your bones when taking Denorange Injection.
Do not take if you are pregnant or plan to become pregnant.
May cause a rare problem of the jaw (osteonecrosis), mostly seen after a dental procedure. Tell your doctor if you develop sudden jaw pain.
Denorange Injection may also increase the risk of infection. Avoid being close to people with cold, flu or other contagious illnesses.
Tell your doctor if you develop a rash while taking Denorange Injection.
Denorange Injection is a medication used to treat thinning of the bones (called osteoporosis).
Take calcium and vitamin D to help build your bones when taking Denorange Injection.
Do not take if you are pregnant or plan to become pregnant.
May cause a rare problem of the jaw (osteonecrosis), mostly seen after a dental procedure. Tell your doctor if you develop sudden jaw pain.
Denorange Injection may also increase the risk of infection. Avoid being close to people with cold, flu or other contagious illnesses.
Tell your doctor if you develop a rash while taking Denorange Injection.

Safety advice

Alcohol

CAUTION

Alcohol should be used with caution while taking Denorange Injection.

Pregnancy

UNSAFE

Denorange Injection is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.

Breast feeding

CONSULT YOUR DOCTOR

Denorange Injection may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.

Driving

SAFE

Denorange Injection does not usually affect your ability to drive.

Kidney

CAUTION

Denorange Injection should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.

Liver

CAUTION

Denorange Injection should be used with caution in patients with severe liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Denorange with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Cinacalcet (Oral Route)

Your doctor may monitor your treatment and adjust the doses as per the observations. Denosumab may increase the metabolism of Cinacalcet.

Frequently asked questions

How long can you stay on Denorange Injection?

There is no optimal duration of treatment of osteoporosis with Denorange Injection. The patient’s response and tolerability to the medicine is continuously monitored through periodic assessments, especially after 5 years of use of Denorange Injection. Depending on this, the duration of taking Denorange Injection is decided.

Does Denorange Injection cause hair loss?

Yes, hair loss is a common side effect of Denorange Injection though it does not affect everyone. Discuss with your doctor if you have concerns regarding your hair loss.

Is Denorange Injection a chemotherapy drug?

Denorange Injection is not a chemotherapy drug. It is a protein (monoclonal antibody) that interferes with the action of another protein in order to treat bone loss and osteoporosis. Treatment with Denorange Injection makes the bones stronger and less likely to break.

How is Denorange Injection given and how often?

Denorange Injection is available as an injection and is given by a healthcare professional. It is given once in 6 months. Your doctor may also advise you to take calcium and vitamin D while taking Denorange Injection.

Can Denorange Injection be taken during pregnancy?

No, pregnant women should not take Denorange Injection. You must use an effective method of birth control during and for at least 5 months after the last dose of Denorange Injection if you can become pregnant.

How should Denorange Injection be stored?

Denorange Injection should be stored in a refrigerator at 36°F to 46°F (2°C to 8°C) in the original carton. Warm temperatures can make it ineffective, and therefore proper storage is necessary. When you remove it from the refrigerator, keep it at room temperature [up to 77°F (25°C)] in the original carton and use it within 14 days.

Does Denorange Injection cause osteonecrosis of the jaw?

Osteonecrosis is a rare side effect of Denorange Injection. It refers to the damage caused to the bone of jaw. To avoid this, you should maintain good oral hygiene and receive routine dental check ups while taking Denorange Injection. Contact your doctor and dentist immediately if you experience any problems with your mouth or teeth such as loose teeth, discharge, pain or swelling, or non-healing of sores. These could be signs of osteonecrosis of jaw.

How long can you stay on Denorange Injection?

Does Denorange Injection cause hair loss?

Yes, hair loss is a common side effect of Denorange Injection though it does not affect everyone. Discuss with your doctor if you have concerns regarding your hair loss.

Is Denorange Injection a chemotherapy drug?

How is Denorange Injection given and how often?

Can Denorange Injection be taken during pregnancy?

How should Denorange Injection be stored?

Does Denorange Injection cause osteonecrosis of the jaw?

Fact Box

Chemical Class

Peptides

Habit Forming

Therapeutic Class

PAIN ANALGESICS

Action Class

Bone Resorption Inhibitors- Monoclonal Antibodies

Related lab tests

Calcium

References

Bikle DD. Agents That Affects Bone Mineral Homoestasis. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 766.
Friedman PA. Agents Affecting Mineral Ion Homeostasis and Bone Turnover. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1299.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 370.
Denosumab. Milton Road, Cambridge: Amgen Ltd.; 2010 [revised Jun. 2018]. [Accessed 02 Apr. 2019] (online) Available from:
Denosumab [Prescribing Information]. Thousand Oaks, California: Amgen Manufacturing Limited; 2013. [Accessed 20 Feb. 2024] (online) Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Biorange Biologicals Private Limited
Address: Shop No 344 Plot No 7 Vardhman Dee Cee Plaza, Sector 11 Dwarka Delhi South West Delhi 110075 India

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Denorange Injection

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Denorange Injection

Benefits of Denorange Injection

Side effects of Denorange Injection

How to use Denorange Injection

How Denorange Injection works

All substitutes for Denorange Injection

Denu Injection

Denoci 60 Injection

Denoci-OP Injection

Odensomab Injection

Denbri Injection

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Cinacalcet (Oral Route)

Frequently asked questions

How long can you stay on Denorange Injection?

Does Denorange Injection cause hair loss?

Is Denorange Injection a chemotherapy drug?

How is Denorange Injection given and how often?

Can Denorange Injection be taken during pregnancy?

How should Denorange Injection be stored?

Does Denorange Injection cause osteonecrosis of the jaw?

How long can you stay on Denorange Injection?

Does Denorange Injection cause hair loss?

Is Denorange Injection a chemotherapy drug?

How is Denorange Injection given and how often?

Can Denorange Injection be taken during pregnancy?

How should Denorange Injection be stored?

Does Denorange Injection cause osteonecrosis of the jaw?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Calcium

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

Related/Popular tests