


Darzine 500mg Injection
Product Summary :
Darzine 500mg Injection is an anti-cancer medicine (alkylating agent) that contains dacarbazine. It is used to treat metastatic melanoma, Hodgkin’s disease, and soft tissue sarcoma in adults. It works by interfering with the growth and DNA production of cancer cells. It is given into a vein by a healthcare professional. Common side effects include loss of appetite, nausea, vomiting, and low blood cell counts. Regular blood, liver, and kidney tests are needed.Written By Dr. Syeda Aafia, MBA, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 27 Oct 2026 | 02:51 PM (IST)
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Product introduction
Darzine 500mg Injection is given as an injection into a vein by the healthcare professional, but better if injected at the same time every day. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The most common side effects of this medicine include nausea, vomiting, and decreased white blood cell count, and injection site pain,. If they do not go away or get worse, tell your doctor. There may be ways of preventing or reducing these effects. It is very strong medicine and some people may develop serious side effects while taking it. This medicine may lower your ability to fight infections and lead to problems with your blood, liver or kidneys. Inform your doctor if you notice unusual bleeding or bruising, lack of energy, loss of appetite, and yellowing of eyes. Your doctor will advise you regular blood tests to check for these.
Before taking it, tell your doctor if you have liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Uses of Darzine Injection
- Malignant melanoma : Used to treat melanoma, a type of skin cancer, when it has spread to other parts of the body. It may be given on its own as chemotherapy.
- Hodgkin’s disease : Used with other chemotherapy medicines to treat advanced Hodgkin’s disease, a type of cancer that affects the lymphatic system.
- Soft tissue sarcoma : Helps to treat cancers that develop in tissues such as muscles, fat, blood vessels, and other supporting tissues.
Benefits of Darzine Injection
Malignant melanoma is a type of skin cancer that can spread to other parts of the body. Darzine 500mg Injection is used to treat melanoma that has spread and may be given on its own. It interferes with the growth and DNA production of cancer cells, helping stop them from multiplying.
Hodgkin’s disease is a cancer of the lymphatic system, which forms part of the body's immune system. Darzine 500mg Injection is used with other chemotherapy medicines to treat advanced disease.
Soft tissue sarcomas are cancers that develop in tissues such as muscles, fat, blood vessels, and other supporting tissues. Darzine 500mg Injection is used with other chemotherapy medicines to treat advanced soft tissue sarcomas in adults, except mesothelioma and Kaposi sarcoma.
Side effects of Darzine Injection
- Decreased white blood cell count (lymphocytes)
- Decreased appetite
- Nausea
- Vomiting
- Anemia (low number of red blood cells)
- Low blood platelets
- Bone marrow suppression
How to use Darzine Injection
How Darzine Injection works
Dosage
The dose, treatment schedule, and duration of Darzine 500mg Injection depend on the type and stage of cancer, whether other chemotherapy medicines are being used, and how well you respond to treatment.
Quick tips
- Avoid live vaccines during treatment. Live-virus vaccines should generally not be given until at least 3 months after chemotherapy is completed.
- Nausea and vomiting can be seen after the treatment. Your doctor may give anti-nausea medicines and supportive treatment to help manage them.
- Darzine 500mg Injection may make your skin more sensitive to sunlight. If you notice increased sensitivity, protect your skin from excessive sun exposure and discuss it with your doctor.
- Do not drive yourself after treatment if you feel nauseous, unusually tired, confused, dizzy, or otherwise unwell, as Darzine 500mg Injection can affect your ability to drive safely.
Safety advice

Alcohol

Pregnancy

Breast feeding

Driving
Darzine 500mg Injection may influence the ability to drive because of its central nervous system side effects.

Kidney

Liver
Interaction with drugs
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Frequently asked questions
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References
- Chabner BA, Bertino J, Cleary J, et al. Cytotoxic Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1686-87.
- Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 942.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 346-47.
- Dacarbazine citrate. Wedel, Germany: medac GmbH; 1997 [revised Jan. 2017]. [Accessed 26 Mar. 2019] (online) Available from:
- Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Dacarbazine. [Updated 2018 Dec 3]. [Accessed 18 Feb. 2020] (online) Available from:
- Dacarbazine citrate. Wedel, Germany: Medac; 2023. [Accessed 18 Feb. 2020] (online). Available from:




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