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Darzine 500mg Injection 1
Darzine 500mg Injection 2
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Darzine 500mg Injection

Dacarbazine (500mg)
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Stored between 2-8°C

Product Summary :

Darzine 500mg Injection is an anti-cancer medicine (alkylating agent) that contains dacarbazine. It is used to treat metastatic melanoma, Hodgkin’s disease, and soft tissue sarcoma in adults. It works by interfering with the growth and DNA production of cancer cells. It is given into a vein by a healthcare professional. Common side effects include loss of appetite, nausea, vomiting, and low blood cell counts. Regular blood, liver, and kidney tests are needed.


Written By Dr. Syeda Aafia, MBA, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 27 Oct 2026 | 02:51 PM (IST)
₹182 MRP ₹191.255% off 
(Inclusive of applicable taxes)
 
 
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General Information

Contains

Dacarbazine (500mg)

Marketer

Samarth Life Sciences Pvt Ltd

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.
The content is shown in English
Darzine 500mg Injection 1
Darzine 500mg Injection 2

Product introduction

Darzine 500mg Injection is used in the treatment of cancers of lymphatic system and malignant melanoma (a type of skin cancer). It may be also used to treat other conditions, as determined by the doctor.

Darzine 500mg Injection is given as an injection into a vein by the healthcare professional, but better if injected at the same time every day. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine include nausea, vomiting, and decreased white blood cell count, and injection site pain,. If they do not go away or get worse, tell your doctor. There may be ways of preventing or reducing these effects. It is very strong medicine and some people may develop serious side effects while taking it. This medicine may lower your ability to fight infections and lead to problems with your blood, liver or kidneys. Inform your doctor if you notice unusual bleeding or bruising, lack of energy, loss of appetite, and yellowing of eyes. Your doctor will advise you regular blood tests to check for these.

Before taking it, tell your doctor if you have liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Darzine Injection

  • Malignant melanoma : Used to treat melanoma, a type of skin cancer, when it has spread to other parts of the body. It may be given on its own as chemotherapy.
  • Hodgkin’s disease : Used with other chemotherapy medicines to treat advanced Hodgkin’s disease, a type of cancer that affects the lymphatic system.
  • Soft tissue sarcoma : Helps to treat cancers that develop in tissues such as muscles, fat, blood vessels, and other supporting tissues.

Benefits of Darzine Injection

Malignant melanoma
Malignant melanoma is a type of skin cancer that can spread to other parts of the body. Darzine 500mg Injection is used to treat melanoma that has spread and may be given on its own. It interferes with the growth and DNA production of cancer cells, helping stop them from multiplying.
Hodgkin’s disease
Hodgkin’s disease is a cancer of the lymphatic system, which forms part of the body's immune system. Darzine 500mg Injection is used with other chemotherapy medicines to treat advanced disease.
Soft tissue sarcoma
Soft tissue sarcomas are cancers that develop in tissues such as muscles, fat, blood vessels, and other supporting tissues. Darzine 500mg Injection is used with other chemotherapy medicines to treat advanced soft tissue sarcomas in adults, except mesothelioma and Kaposi sarcoma.

Side effects of Darzine Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Darzine
  • Decreased white blood cell count (lymphocytes)
  • Decreased appetite
  • Nausea
  • Vomiting
  • Anemia (low number of red blood cells)
  • Low blood platelets
  • Bone marrow suppression

How to use Darzine Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Darzine Injection works

Darzine 500mg Injection is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.

Dosage

The dose, treatment schedule, and duration of Darzine 500mg Injection depend on the type and stage of cancer, whether other chemotherapy medicines are being used, and how well you respond to treatment.

Quick tips

  • Avoid live vaccines during treatment. Live-virus vaccines should generally not be given until at least 3 months after chemotherapy is completed.
  • Nausea and vomiting can be seen after the treatment. Your doctor may give anti-nausea medicines and supportive treatment to help manage them.
  • Darzine 500mg Injection may make your skin more sensitive to sunlight. If you notice increased sensitivity, protect your skin from excessive sun exposure and discuss it with your doctor.
  • Do not drive yourself after treatment if you feel nauseous, unusually tired, confused, dizzy, or otherwise unwell, as Darzine 500mg Injection can affect your ability to drive safely.

Safety advice

Alcohol

Alcohol

UNSAFE
It is unsafe to consume alcohol with Darzine 500mg Injection
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Darzine 500mg Injection is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Darzine 500mg Injection may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving

Driving

UNSAFE
Darzine 500mg Injection may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Darzine 500mg Injection may influence the ability to drive because of its central nervous system side effects.
Kidney

Kidney

SAFE IF PRESCRIBED
Darzine 500mg Injection is probably safe to use in patients with kidney disease. Limited data suggest dose adjustment may not be needed.
Liver

Liver

SAFE IF PRESCRIBED
Darzine 500mg Injection is probably safe to use in patients with liver disease. Limited data suggest dose adjustment may not be needed.

Interaction with drugs

Taking Darzine with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Severe

Cholera Vaccine (Inactivated) (Oral Route)

Do not use Dacarbazine with Cholera Vaccine (Inactivated). If Dacarbazine is essential, ensure a gap of At least 6 months after discontinuing Cholera Vaccine (Inactivated). Please consult your doctor. Dacarbazine may reduce efficacy of Cholera Vaccine (Inactivated).
Severe

Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted) (Injection Route)

Do not use Dacarbazine with Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted). If Dacarbazine is essential, ensure a gap of At least 6 months after discontinuing Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted). Please consult your doctor. Dacarbazine may reduce efficacy of Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted).
Severe

Purified Vi Polysaccharide Typhoid Vaccine (Injection Route)

Do not use Dacarbazine with Purified Vi Polysaccharide Typhoid Vaccine. If Dacarbazine is essential, ensure a gap of At least 6 months after discontinuing Purified Vi Polysaccharide Typhoid Vaccine. Please consult your doctor. Dacarbazine may reduce efficacy of Purified Vi Polysaccharide Typhoid Vaccine.
Severe

Pegfilgrastim (Injection Route)

Do not consume Dacarbazine from 14 days before until 24 days after taking Pegfilgrastim. Please consult your doctor. Dacarbazine may reduce the efficacy of Pegfilgrastim.
Severe

Sargramostim (Injection Route)

Do not consume Dacarbazine from 1 day before until 1 day after taking Sargramostim. Please consult your doctor. Dacarbazine may reduce the efficacy of Sargramostim.

Frequently asked questions

Darzine 500mg Injection is administered as infusion or injection. Absorption by mouth is slow and varies, therefore, intravenous (given through vein) infusion or injection administration is preferred.
Darzine 500mg Injection is used to treat skin cancer that has spread to other parts of the body (malignant melanoma), cancer of the white blood cell (Hodgkin's lymphoma) and advanced adult soft tissue sarcomas (cancer of soft tissues such as muscles, tendons, fat, and blood vessels).
No. Darzine 500mg Injection is used as part of combination chemotherapy for advanced soft tissue sarcomas in adults, but specifically excludes mesothelioma and Kaposi sarcoma
Yes. Some people may experience tiredness, chills, fever, and muscle pain during treatment or even a few days afterward. These symptoms may occur again with a later infusion.
Limited information is available on its safety and effectiveness in children and adolescents younger than 15 years.

Fact Box

Chemical Class

2- heteroaryl carboxamides

Habit Forming

No

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Alkylating Agents

References

  1. Chabner BA, Bertino J, Cleary J, et al. Cytotoxic Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1686-87.
  2. Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 942.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 346-47.
  4. Dacarbazine citrate. Wedel, Germany: medac GmbH; 1997 [revised Jan. 2017]. [Accessed 26 Mar. 2019] (online) Available from:
  5. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Dacarbazine. [Updated 2018 Dec 3]. [Accessed 18 Feb. 2020] (online) Available from:
  6. Dacarbazine citrate. Wedel, Germany: Medac; 2023. [Accessed 18 Feb. 2020] (online). Available from:
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Samarth Life Sciences Pvt Ltd
Address: Samarth House, 168, Bangur Nagar, Off Link Road, Near Ayappa Temple & Kallol Kali Temple, Goregaon (W), Mumbai - 400 090.

Vendor Details

Country of origin: India
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