D-NIB Injection
Prescription Required
Product introduction
D-NIB Injection is used in the treatment of blood cancer called acute myeloid leukaemia (AML). It is also used to treat patients with myelodysplastic syndrome (MDS). It may be used to treat other conditions, as determined by the doctor.
D-NIB Injection is also used with certain other medicines as part of combination chemotherapy. It is given as an injection into the vein under the supervision of a doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The most common side effects of this medicine include nausea, vomiting, diarrhea, headache, fever and lung infection. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels.
Before taking it, tell your doctor if have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. Use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Uses of D-NIB Powder for Injection
Benefits of D-NIB Powder for Injection
In Blood cancer
Blood cancer, also called leukemia, is a cancer of the blood-forming tissues, that decreases the body's ability to fight infection. D-NIB Injection kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is an effective medicine but you should discuss the side effects and benefits of this medicine with your doctor. Let your doctor know if any of the side effects bothers you.
In Myelodysplastic syndrome
D-NIB Injection is used to treat myelodysplastic syndrome, a group of conditions in which the bone marrow produces blood cells that are abnormal in structure and function, and does not produce enough healthy blood cells. D-NIB Injection kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is an effective, yet very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.
Side effects of D-NIB Powder for Injection
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of D-NIB
- Nausea
- Vomiting
- Headache
- Fever
- Lung infection
- Decreased white blood cell count (neutrophils)
- Nosebleeds
- Anemia (low number of red blood cells)
- Low blood platelets
- Diarrhea
- Pneumonia
How to use D-NIB Powder for Injection
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How D-NIB Powder for Injection works
D-NIB Injection interferes with the growth of DNA and RNA of the cancer cells by substituting their building blocks. It prevents the cancer cells from growing and multiplying.
Safety advice
Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with D-NIB Injection. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
D-NIB Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breast feeding
UNSAFE
D-NIB Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving
UNSAFE
D-NIB Injection may cause side effects which could affect your ability to drive.
You may feel tired or weak after using D-NIB Injection this could affect your ability to drive.
You may feel tired or weak after using D-NIB Injection this could affect your ability to drive.
Kidney
CAUTION
D-NIB Injection should be used with caution in patients with kidney disease. Dose adjustment of D-NIB Injection may be needed. Please consult your doctor.
Liver
CONSULT YOUR DOCTOR
There is limited information available on the use of D-NIB Injection in patients with liver disease. Please consult your doctor.
What if you forget to take D-NIB Powder for Injection?
If you miss a dose of D-NIB Injection, please consult your doctor.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
No substitutes found for this medicine
Quick tips
- Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine.
- Inform your doctor immediately if you notice any signs of infection such as fever, sore throat, rash or severe diarrhea.
Fact Box
Chemical Class
Azacitidine Derivative
Habit Forming
No
Therapeutic Class
ANTI NEOPLASTICS
Action Class
Antimetabolites
Interaction with drugs
Taking D-NIB with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Do not consume Natalizumab with Decitabine.
Concomitant use may increase the risk of opportunistic infections.
Do not consume Decitabine from 14 days before until 24 days after taking Pegfilgrastim. Please consult your doctor.
Concurrent use may cause a decrease in the ability of the bone
Do not consume Decitabine from 1 day before until 1 day after taking Sargramostim. Please consult your doctor.
Concurrent use may cause a decrease in the ability of the bone marro
Do not consume Lenograstim from 24 hours before until 24 hours after undergoing cytotoxic chemotherapy.
Concurrent use may cause a decrease in the ability of the bone marrow to pr
Do not use Decitabine with Purified Vi Polysaccharide Typhoid Vaccine. If Decitabine is essential, ensure a gap of at least 6 months after discontinuing Purified Vi Polysaccharide
Patient concerns
User feedback
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FAQs
Is D-NIB Injection a vesicant?
D-NIB Injection is not a vesicant and is not known to cause severe local tissue damage upon extravasation (leaking of injected D-NIB Injection into the surrounding tissues from the site of administration) when injected.
How effective is D-NIB Injection?
The effectiveness of D-NIB Injection depends upon several factors including the patient's clinical condition, number of treatment cycles etc. and may vary depending upon the individual response.
Does D-NIB Injection cause hair loss?
Yes. Hair loss (alopecia) is among the known side effects of D-NIB Injection.
How is D-NIB Injection administered?
D-NIB Injection comes as a powder to be to be added to fluid and injected slowly over 3 hours into a vein (slow i.v infusion) by a doctor who is experienced in giving chemotherapy medications for cancer in a hospital or a clinic.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 364.
- Decitabine. High Wycombe, Bucks: Janssen-Cilag Ltd.; 2012 [revised 07 Feb. 2019]. [Accessed 26 Mar. 2019] (online) Available from:
- Decitabine. Netherlands: Pharmachemie B.V.; 2006 [revised date]. [Accessed 26 Mar. 2019] (online) Available from:
- Central Drugs Standard Control Organisation (CDSCO). [Accessed 27 Mar. 2019] (online) Available from:
Marketer details
Name: BDR Pharmaceuticals Internationals Pvt
Address: 407-408, Sharda Chambers, New Marine Lines, Mumbai 400 020 (Maharashtra), New Marine Lines, Marine Lines, Mumbai, Maharashtra 400020
Country of origin: India
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₹3276
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MRP₹3563.14 8% OFF
1.0 Powder for Injection in 1 vial
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