COXWIN 4FD TABLET

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iconPrescription Required

Primarily used for

Potentiallyunsafewith
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Alcohol
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Pregnancy
45.1
₹7.52/tablet
6 tablets in 1 strip
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Substitutes for COXWIN 4FD

No substitutes found for this medicine

Medicine Overview of COXWIN 4FD TABLET

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Uses of Isoniazid

Isoniazid is used in the treatment of tuberculosis (tb).
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Side effects of Isoniazid

Common

Peripheral neuropathy (tingling and numbness of feet and hand), Increased liver enzymes, Hepatitis (viral infection of liver), Jaundice.

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How to use Isoniazid

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Avoid Coxwin 4fd tablet with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.

How COXWIN 4FD TABLET works

Isoniazid is an antibiotic. It works by killing the bacteria that causes tuberculosis.
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Uses of Rifampicin

Rifampicin is used in the treatment of tuberculosis (tb) and leprosy.
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Side effects of Rifampicin

Common

Skin rash, Nausea, Vomiting, Chills, Muscle pain.

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How to use Rifampicin

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Avoid Coxwin 4fd tablet with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.

How COXWIN 4FD TABLET works

Rifampicin is an antibiotic. It works by killing the bacteria that cause infections.
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Uses of Ethambutol

Ethambutol is used in the treatment of tuberculosis (tb).
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Side effects of Ethambutol

Common

Visual impairment, Color blindness.

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How to use Ethambutol

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Avoid Coxwin 4fd tablet with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.

How COXWIN 4FD TABLET works

Ethambutol is an antibiotic. It works by slowing the growth of bacteria that causes tuberculosis.
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Uses of Pyrazinamide

Pyrazinamide is used in the treatment of tuberculosis.
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Side effects of Pyrazinamide

Common

Jaundice, Hepatitis (viral infection of liver), Increased liver enzymes, Joint pain.

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How to use Pyrazinamide

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Avoid Coxwin 4fd tablet with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.

How COXWIN 4FD TABLET works

Pyrazinamide is an antibiotic. It works by slowing the growth of bacteria that causes tuberculosis.

In Depth Information on COXWIN 4FD TABLET

Expert advice for Isoniazid

  • Do not take isoniazid, if you have severe liver problems or if you have taken isoniazid in the past and it caused liver problems, fever, chills, joint pain, or severe allergic reaction.
  • Contact your doctor immediately, if you experience symptoms such unusual tiredness (fatigue), weakness, feeling of discomfort (malaise), loss of appetite (anorexia), urge to vomit (nausea) or vomiting while taking isoniazid. It indicates that you are progressing towards liver damage.
  • Do consult your doctor before taking isoniazid if you are aged above 35 years. The frequency of isoniazid related inflammation of liver (hepatitis) is higher in individuals older than 35 years of age. The doctor may advice measurement of blood levels of enzyme transferases before starting treatment with isoniazid.
  • Avoid drinking alcohol. It may increase your risk of liver damage while you are taking isoniazid.
  • Do consult your doctor before taking isoniazid, if you are pregnant or planning to become pregnant or are breastfeeding.
  • Isoniazid interacts with many drugs. Please inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects.
  • Do not stop taking isoniazid without consulting your doctor.
  • If you forget to take a dose of Isoniazid, take it as soon as you remember. Do not double the dose to make up for the missed dose.

Expert advice for Rifampicin

  • Rifampin interacts with many drugs. Please inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects.
  • Do consult your doctor before taking rifampin if you wear contact lenses. Using rifampin may permanently stain your contact lenses.
  • Taking rifampin may produce a brownish-red coloration of the urine, sweat, sputum and tears. This is not a harmful effect.
  • Do consult your doctor before taking rifampin if you are pregnant or planning to become pregnant.
  • Do consult your doctor if you are taking oral contraceptive medications for birth control. Your doctor may ask you to use other means of birth control (eg. condom, diaphragm with spermicide) to prevent pregnancy while taking rifampin.
  • Do consult your doctor before taking rifampin if you are breast-feeding.
  • Do consult your doctor before taking rifampin if you are aged 65 years or above.
  • If you take rifampin irregularly or if daily administration is resumed after a drug free interval, you may experience ‘flu syndrome’ (includes episodes of fever, chills, headache, dizziness, and bone pain).
  • Rifampin should preferably be taken in the morning before breakfast. Taking rifampin with food is known to delay its absorption (process by which the active drug reaches the affected site in the body via blood circulation) thereby, hampering its effectiveness.
  • Do not stop taking rifampin without consulting your doctor.

Expert advice for Ethambutol

Do consult your doctor before taking ethambutol if you have any eye problems such as cataracts (disturbed vision due to clouding of eye lenses) , recurrent inflammatory conditions of the eye, optic neuritis (inflammation of nerve fibers that transmit visual information from your eye to the brain), and diabetic retinopathy (a complication of eye due to diabetes). Ethambutol can cause serious eye damage. Regular eye checkups are recommended while on treatment with ethambutol. Do consult your doctor before taking ethambutol:
  • If you have kidney problems.
  • If you have liver problems.
  • If you have gout (pain, swelling, redness and stiffness in joints due to accumulation of uric acid).
Ethambutol is not recommended for use in children aged below 3 years. Do consult your doctor before taking ethambutol if you are pregnant or planning to become pregnant. Do consult your doctor before taking ethambutol if you are breastfeeding. Do not stop taking ethambutol without consulting your doctor. If you forget to take a dose of ethambutol, take it as soon as you remember. Do not double the dose to make up for the missed dose.

Expert advice for Pyrazinamide

  • Avoid alcoholic beverages while taking this drug.
  • Do not have any immunizations/vaccinations while using this medication without the consent of your doctor.
  • Contact your doctor immediately if you experience symptoms such as persistent nausea,  vomiting, feeling of discomfort (malaise) or jaundice (abnormal liver function causing yellowing of skin and eyes) while taking pyrazinamide. It indicates that you are developing liver disease.
  • Constant monitoring of liver function (especially levels of enzymes aspartate transferase [AST] and alanine transferase [ALT]) and blood uric acid levels is advised while on treatment with pyrazinamide.
  • Do consult your doctor before taking pyrazinamide if you are pregnant or planning to become pregnant.
  • Do not use pyrazinamide, if you are breast-feeding.
  • Do not stop taking pyrazinamide without consulting your doctor.
  • If you forget to take a dose of pyrazinamide, take it as soon as you remember. Do not double the dose to make up for the missed dose.
  • Do consult your doctor if you are taking oral contraceptive medications (hormonal birth control pills) for birth control. Your doctor may ask you to use other means of birth control (eg. condom, diaphragm with spermicide) to prevent pregnancy while taking pyrazinamide.
Warnings
Special precautions for COXWIN 4FD TABLET
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Alcohol
CAUTION
Coxwin 4fd tablet may cause symptoms such as flushing, incre
ased heartbeat, nausea, thirst, chest pain and low blood pressure with alcohol (Disulfiram reactions).
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Pregnancy
WEIGH RISKS VS BENEFITS
Coxwin 4fd tablet may be unsafe to use during pregnancy.

Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
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Lactation
SAFE
Coxwin 4fd tablet is probably safe to use during breastfeeding. Please consult your doctor.
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Driving
CAUTION
Caution is advised when driving or operating machinery.
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Kidney
CAUTION
Caution to be advised in patients with impaired renal function.

Caution should be used in patients with renal impairment.
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Liver
There is no data available. Please consult doctor before consuming the drug.

Patient Concerns

Frequently asked questions for COXWIN 4FD TABLET

Frequently asked questions for Isoniazid

Q. Is isoniazid an antibiotic?
Isoniazid is an antibiotic used in the prevention and treatment of tuberculosis or TB (a serious infection caused by bacteria that affects the lungs and in certain cases other parts of the body)
Q. Is isoniazid chemotherapy/chemotherapy drug?
Isoniazid is a primary antibiotic used for treatment of tuberculosis. Do not confuse it with chemotherapy or chemo drugs used for the treatment of cancer
Q. Is isoniazid bacteriostatic or bactericidal?
Isoniazid is a bacteriostatic antibiotic. It stops or suppresses growth of tuberculosis causing bacteria by interfering with the formation of protective outer covering (cell wall) which is essential for their growth
Q. Is isoniazid safe?
Yes. Isoniazid is safe if used at prescribed doses for the prescribed duration as advised by your doctor
Q. Is isoniazid a MAOI?
Isoniazid has very weak inhibitory activity on enzymes monoamine oxidases (MAO); however it is not used as a monoamine oxidase inhibitor (MAOI)
Q. Is isoniazid a sulfa drug?
No. The chemical structure and mechanism of action of isoniazid is different from sulfa drugs
Q. Is isoniazid an inducer or inhibitor?
Isoniazid is an inhibitor (decreases activity) of an important liver enzyme system that is responsible for the final processing and elimination of several drugs from the body
Q. Can I take isoniazid with ibuprofen/Benadryl/Nyquil/Aleve/Mucinex/amoxicillin?
There no known serious drug interactions of isoniazid with ibuprofen, paracetamol (trade name: Tylenol), naproxen (trade name: Aleve), amoxicillin or any active drug present in Nyquil or Mucinex. Please inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects
Q. Does isoniazid cause weight loss/weight gain/hair loss/diarrhea/affect menstruation?
Changes in body weight (gain/loss), hair loss, diarrhea or changes in menstruation are not among the known side effects of isoniazid. You may experience few of these side effects while on multi drug (including isoniazid) treatment for tuberculosis
Q. Does isoniazid cause acne/make you tired/cause constipation?
You may experience unusual tiredness, constipation or acne while on treatment with isoniazid. Please inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects
Q. Does isoniazid affect birth control?
Isoniazid has no known interaction with commonly used oral contraceptives (birth control pills). However, multidrug treatment for tuberculosis contains active drug rifampin that decreases the effectiveness of oral contraceptives and hampers birth control.
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Frequently asked questions for Rifampicin

Q. Is rifampin and rifampicin same?
Yes. Rifampin (nomenclature in the United States) and rifampicin (nomenclature in Britain) is the same antibiotic commonly used in the treatment of tuberculosis and leprosy
Q. Is rifampin a penicillin/amoxicillin/sulfa drug?
No. Rifampin is an antibiotic commonly used in the treatment of tuberculosis and leprosy. It has a structure and mechanism of action different from penicillin or amoxicillin (amoxicillin belongs to the class of penicillin antibiotics). The chemical structure and mechanism of action of rifampin is different from sulfa drugs
Q. Is rifampin bacteriostatic or bactericidal?
Rifampin is a bactericidal drug. It acts by blocking the activity of a bacterial enzyme called DNA-dependent RNA polymerase which essential for important life processes in the bacteria, thereby killing the bacteria
Q. Is rifampin an inducer or inhibitor?
Rifampin is an inducer (increases activity) of an important liver enzyme system that is responsible for the final processing and elimination of several drugs from the body
Q. What is R-cin 600 used for?
R-cin 600 is a trade name for active drug rifampin 600 mg. Rifampin is an antibiotic commonly used in the treatment of tuberculosis and leprosy. It is also used in the prevention of meningococcal meningitis and Haemophilus influenza infections. It may also be used in combination with other drugs to treat infections-Brucellosis, Legionnaires disease or serious staphylococcal infections
Q. What is R-cinex/Macox plus/R-cinex 600?
R-cinex and Macox plus are trade names for a combination of active drugs rifampin and isoniazid. It is used in the treatment of tuberculosis. R-cinex 600 and Macox plus contains 600 mg of active drug rifampin and 300 mg of active drug isoniazid
Q. Can I take rifampin with ibuprofen/acetaminophen (Tylenol)?
Rifampin has no known serious drug interaction with ibuprofen or acetaminophen (trade name: Tylenol). Inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects
Q. Does rifampin cause weight gain/weight loss/ hair loss/ constipation/ yeast infection?
No. Changes in body weight, hair loss or triggering constipation are not among the known side effects of rifampin. Rifampin is an antibiotic commonly used in the treatment of tuberculosis and leprosy. It has no known effect on causing yeast infections
Q. Does rifampin cause headaches?
Yes. Headache is a possible side effect of rifampin
Q. Does rifampin change urine color/turn urine orange?
Yes. Taking rifampin may change the color of your urine (skin, sweat, saliva, tears and feces) to brownish-red or orange. This effect is not harmful
Q. Does rifampin cause liver damage?
Rifampin is safe when used at prescribed doses for the prescribed duration. Constant monitoring of liver function is important while on treatment with rifampin. Taking drugs like saquinavir, ritonavir with rifampin can cause severe liver damage. Do consult your doctor if you have any liver problem before taking rifampin.
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Frequently asked questions for Ethambutol

Q. Does ethambutol cause blindness?
Optic neuritis (inflammation of nerve fibers that transmit visual information from your eye to the brain) is one of the side effects of ethambutol which causes several forms of eye defect. Although these conditions are reversible upon discontinuation of the drug, rare cases of irreversible blindness have also been reported. Please contact your doctor immediately if you notice any of these symptoms: decreased clearness of vision, loss of vision, disturbed vision due to blind spots, color blindness, visual field defect and eye pain
Q. Does ethambutol induce hyperuricemia/how does ethambutol induce hyperuricemia?
Yes. Increase in blood levels of uric acid is a side effect of ethambutol. It increases the retention of uric acid in the body by decreasing the excretion of urates (uric acid) by the kidneys
Q. How does ethambutol work in the body?
Ethambutol is an antibiotic effective against tuberculosis causing bacteria. It suppresses the growth of the bacteria by interfering with the formation of the outer protective covering (cell wall) of the bacteria, thereby weakening the bacteria
Q. What is ethambutol toxicity/How does ethambutol cause optic neuritis/how does ethambutol affect vision?
Ethambutol toxicity involves toxic effects on the eyes (optic neuritis/optic neuropathy) which are related to the dose and duration of ethambutol treatment. It causes optic neuritis (inflammation of nerve fibers in the eye) by interfering with important cellular activities (mitochondrial toxicity) in the nerve cells and inducing nerve damage (neuropathy) thereby affecting the transmission of visual information from the eye to brain. The symptoms of ethambutol induced optic neuritis include: decreased clearness of vision, loss of vision, disturbed vision due to blind spots, color blindness, visual field defect and eye pain
Q. What does ethambutol treat?
Ethambutol is an antibiotic effective against tuberculosis causing bacteria. It is used in the prevention, treatment and second time treatment of tuberculosis (a serious infection caused by bacteria that affects the lungs and in certain cases other parts of the body)
Q. Is ethambutol bacteriostatic or bactericidal?
Ethambutol is both a bacteriostatic and a bactericidal antibiotic. It suppresses the growth of bacteria (bacteriostatic) by interfering with the formation of the outer protective covering (cell wall) of the bacteria, thereby weakening it and causing cell death in certain cases (bactericidal)
Q. Is ethambutol hepatotoxic?
Liver toxicities are among the known side effects of ethambutol. Inflammation of liver (hepatitis), abnormal liver function causing yellowing of skin and eyes (jaundice), abnormal liver function tests (blood tests to assess health of liver) and very rarely liver failure have been noted in patients receiving multi drug (including ethambutol) treatment for tuberculosis. Please contact your doctor before taking ethambutol if you have any liver problems
Q. Is ethambutol toxicity reversible?
In most cases ethambutol toxicities are related to dose (depends upon the quantity of ethambutol you take) and duration of treatment and are reversible upon discontinuation. However, serious irreversible damage to eye and liver has been reported in rare cases
Q. Is ethambutol chemotherapy?
Ethambutol is an antibiotic used in the treatment of tuberculosis. Do not confuse it with chemotherapy or chemo drugs used for the treatment of cancer
Q. Ethambutol is effective against?
Ethambutol is effective against most tuberculosis causing bacteria belonging to Mycobacterium family (M. tuberculosis, M. avium complex, M. kansasii, M. marinum).
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Frequently asked questions for Pyrazinamide

Q. What is pyrazinamide and what is it used for?
Pyrazinamide is an antibiotic. It is used in combination with other antibiotics in the treatment of tuberculosis
Q. Is pyrazinamide bactericidal?
Pyrazinamide is both a bacteriostatic and a bactericidal antibiotic. It stops the growth of bacteria (bacteriostatic) in certain cases and kills (bactericidal) the tuberculosis causing bacteria in other cases
Q. How does pyrazinamide work/treat tuberculosis?
Pyrazinamide kills or stops growth of bacteria that causes tuberculosis (Mycobacterium tuberculosis). The exact mechanism of action for pyrazinamide is not known
Q. How does pyrazinamide cause hyperuricemia and gout?
Following oral intake of pyrazinamide, it gets converted in the body to pyrazinoic acid (active chemical form of pyrazinamide). Pyrazinoic acid blocks the excretion of urates (salt form of uric acid) by the kidneys. This causes an increase in blood levels of uric acid (hyperuricemia). Excess uric acid accumulation between joints causes pain, swelling, redness and stiffness in joints (gout).
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