Isoniazid + Rifampicin + Ethambutol + Pyrazinamide
Information about Isoniazid + Rifampicin + Ethambutol + Pyrazinamide
Isoniazid + Rifampicin + Ethambutol + Pyrazinamide Uses
Isoniazid+Rifampicin+Ethambutol+Pyrazinamide is used in the treatment of tuberculosis.
How Isoniazid + Rifampicin + Ethambutol + Pyrazinamide works
Isoniazid + Rifampicin + Ethambutol + Pyrazinamide is a combination of four medicines: Isoniazid, rifampicin, ethambutol and pyrazinamide which treat tuberculosis. Isoniazid works by preventing the TB bacteria from forming their own protective covering, while rifampicin inactivates a bacterial enzyme (RNA-polymerase) which is required by TB bacteria to make essential proteins and to reproduce. Together, they kill the bacteria and eradicate the infection. Ethambutol and pyrazinamide on the other hand, work by slowing the growth of these bacteria.
Common side effects of Isoniazid + Rifampicin + Ethambutol + Pyrazinamide
Nausea, Vomiting, Peripheral neuropathy (tingling and numbness of feet and hand), Abdominal pain, Skin rash, Hepatitis (viral infection of liver), Lethargy, Low blood platelets, Joint pain, Thrombocytopenic purpura, Cutaneous reactions, Retrobulbar optic neuritis
Available Medicine for Isoniazid + Rifampicin + Ethambutol + Pyrazinamide
ForecoxMacleods Pharmaceuticals Pvt Ltd
₹33 to ₹993 variant(s)
Akt 4Lupin Ltd
₹321 variant(s)
Akurit 4Lupin Ltd
₹991 variant(s)
MycuritCadila Pharmaceuticals Ltd
₹33 to ₹473 variant(s)
R-Cinex EZLupin Ltd
₹901 variant(s)
Trac 4Macleods Pharmaceuticals Pvt Ltd
₹591 variant(s)
AKT-FDLupin Ltd
₹251 variant(s)
Monto 4Shreya Life Sciences Pvt Ltd
₹161 variant(s)
Scc 4 LWManeesh Pharmaceuticals Ltd
₹10 to ₹232 variant(s)
Vicox EZShrinivas Gujarat Laboratories Pvt Ltd
₹551 variant(s)
Expert advice for Isoniazid + Rifampicin + Ethambutol + Pyrazinamide
- You have been prescribed Isoniazid + Rifampicin + Ethambutol + Pyrazinamide for the treatment of tuberculosis.
- Take it on an empty stomach and preferably at the same time everyday.
- Try not to forget a dose, as this increases the risk of the bacteria becoming resistant to the medicine, and also increases the risk of getting side effects.
- It may discolour your urine, sweat, saliva and tears a reddish/orange colour. This is normal and not harmful.
- Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.
- Avoid drinking alcohol while taking Isoniazid + Rifampicin + Ethambutol + Pyrazinamide as this may increase the risk of side effects on the liver.
- It may cause vitamin B6 deficiency. Your doctor may prescribe vitamin B6 supplements to help avoid potential problems associated with its deficiency, such as inflammation of the nerves (neuritis).
- Use a reliable contraceptive method (such as condoms or a diaphragm) to prevent pregnancy while you are taking Isoniazid + Rifampicin + Ethambutol + Pyrazinamide as it may make hormonal contraceptives such as the pill less effective.
- Do not take indigestion remedies (antacids) within at least two hours of taking Isoniazid + Rifampicin + Ethambutol + Pyrazinamide.
- Finish the full course of the medication, even if you feel better. Stopping the course early increases the risk of coming back of the infection.