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Cafirate Tablet

Written By Dr. Sakshi Jain, MS, BDS
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS
Last updated on 10 Apr 2026 | 01:08 AM (IST)
Cafirate Tablet is a prescription medicine used in the treatment of apnea (a disorder in which breathing repeatedly stops and starts) of prematurity. It facilitates normal breathing and reduces interrupted breathing in premature newborns.
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General Information

Contains

Caffeine (NA)

Marketer

Sun Pharmaceutical Industries Ltd

Storage

Store below 30°C
The content is shown in English
Cafirate Tablet image
Cafirate Tablet image

Product introduction

Cafirate Tablet is given under the supervision of healthcare professionals. It is given by mouth or via a gastric feeding tube only. Remember, if you are breastfeeding while your infant is treated with this medicine, then do not drink coffee or take any other high caffeine product as this passes into breast milk.

Some common side effects of using this medicine are restlessness, insomnia, headaches, dizziness, increased heart rate. Consult your doctor if these persist for a longer duration or get worse. They may be able to suggest ways to prevent or reduce these side effecrts. 

Uses of Cafirate Tablet

  • Apnea of prematurity

Benefits of Cafirate Tablet

Apnea of prematurity
Apnea of prematurity is a condition seen in premature babies where they stop breathing for short periods due to their underdeveloped breathing control system. Cafirate Tablet helps reduce the number and length of these breathing pauses, supporting more stable and regular breathing patterns. It improves oxygen levels, reduces the need for breathing support, and helps promote healthier growth and development during the early stages of life.

Side effects of Cafirate Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Cafirate
  • Restlessness
  • Headache
  • Insomnia (difficulty in sleeping)
  • Dizziness
  • Increased heart rate

How to use Cafirate Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Cafirate Tablet may be taken with or without food.

How Cafirate Tablet works

Cafirate Tablet is a stimulant. It works by blocking the action of certain natural substances (adenosine and phosphodiesterase) leading to stimulation of the brain and respiratory system in premature newborns. This reduces the number of episodes of interrupted breathing and helps the newborns breathe on their own.

Quick tips

  • Cafirate Tablet helps in the treatment of interrupted breathing in premature babies.
  • If you are breast-feeding while your infant is treated with Cafirate Tablet, do not drink coffee or take any other high caffeine product as caffeine passes into breast milk.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Cafirate Tablet. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of Cafirate Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

CAUTION
Cafirate Tablet should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.
Driving

Driving

NOT RELEVANT
Not relevant, as Cafirate Tablet is intended for use in hospitalized patients.
Kidney

Kidney

CAUTION
Cafirate Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Liver

Liver

CAUTION
Cafirate Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Cafirate with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Moderate

Phenobarbitone (Oral Route)

It is recommended to avoid Caffeine after taking Phenobarbitone, especially at bedtime. Caffeine may reduce the efficacy of Phenobarbitone.
Moderate

Leflunomide (Oral Route)

Your doctor may monitor the effects of Leflunomide when taken concurrently with Caffeine. Caffeine may reduce blood levels of Leflunomide.
Moderate

Adenosine (Oral Route)

It is recommended to avoid Caffeine for at least 24 hours before taking Adenosine. Please consult your doctor accordingly. Caffeine may reduce the efficacy of Adenosine.
Moderate

Axitinib (Oral Route)

If concurrent use is essential, watch out for symptoms such as acute confusional state, difficulty in sleeping, frequent urge to urinate or fever and consult your doctor if you experience them. They may adjust the doses as per the observations. Axitinib may raise blood levels of Caffeine.
Moderate

Adenosine (Injection Route)

It is recommended to avoid Caffeine for at least 24 hours before taking Adenosine. Please consult your doctor accordingly. Caffeine may reduce the efficacy of Adenosine.

Frequently asked questions

Cafirate Tablet is a medicine given to premature babies who have apnea of prematurity. This condition causes infants to stop breathing for short periods because their breathing system is not fully developed. The medicine helps stimulate the baby’s brain and lungs to improve breathing.
Cafirate Tablet works by stimulating the central nervous system and the baby’s breathing center. It makes the brain more responsive to carbon dioxide and helps reduce episodes where the baby stops breathing. It also improves muscle tone and decreases fatigue of the diaphragm, the muscle that controls breathing.
Cafirate Tablet should not be given to infants who are allergic or hypersensitive to caffeine, or any of the ingredients in the medicine. If a baby has shown any allergic reaction to caffeine in the past, this medicine should be avoided.
One of the most serious risks linked to Cafirate Tablet is necrotizing enterocolitis (a life-threatening bowel condition), which has been reported in premature babies during clinical studies. Because of this, babies receiving this medicine must be closely monitored for abdominal bloating, vomiting, bloody stools, unusual sleepiness, or sudden changes in energy levels.
No, Cafirate Tablet is meant only for short-term treatment of apnea of prematurity, typically for 10 to 12 days. Its safety and effectiveness for long-term use, or for other conditions such as sudden infant death syndrome (SIDS), have not been proven.
Before starting Cafirate Tablet treatment, doctors should rule out other possible causes of apnea, such as infections, anemia, or lung disease. They may also need to check caffeine levels in babies who were previously given theophylline, or whose mothers consumed caffeine before delivery, since these can affect blood caffeine levels.
While the baby is on Cafirate Tablet treatment, parents or caregivers should immediately contact the doctor if the baby develops a swollen belly, vomiting, bloody stools, unusual sleepiness, or seems unwell. These may be signs of serious complications such as necrotizing enterocolitis.

Fact Box

Chemical Class

Xanthine derivative

Habit Forming

No

Therapeutic Class

RESPIRATORY

Action Class

Adenosine receptor (A1 & A2) antagonist

References

  1. O’Brien CP. Drug Addiction. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 663.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 179-83.
  3. Tulane University: School of Medicine. Caffeine. [Accessed 29 Jan. 2019] (online) Available from:
  4. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Caffeine. [Updated 2019 Jun 30]. [Accessed 20 Feb. 2020] (online) Available from:
  5. Caffeine. Harold Hill: Macarthys Laboratories Limited; 2011 [revised 8 Aug. 2018]. (online) Available from:
  6. Central Drugs Standard Control Organisation (CDSCO). [Accessed 20 Mar. 2019] (online) Available from:
  7. Caffeine. Lake Zurich, IL: Fresinius, Kabi; 2019.
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Sun Pharmaceutical Industries Ltd
Address: Khasra No. 1335-1340,Near EPIP- I, Vill - Bhatoli Kalan ,Baddi, Solan, Himachal Pradesh, 173205 || Plot no 107/108,Namli block , Ranipool, East Sikkim 737135 || Acme Plaza, Andheri-Kurla Road, Andheri (East), Mumbai, Maharashtra -400059

Vendor Details

Country of origin: India

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