Cafirate Injection
Product introduction
Cafirate Injection is a prescription medicine used in the treatment of apnea (a disorder in which breathing repeatedly stops and starts) of prematurity. It facilitates normal breathing and reduces interrupted breathing in premature newborns.
Cafirate Injection is given under the supervision of healthcare professionals. Remember, if you are breastfeeding while your infant is treated with this medicine, then do not drink coffee or take any other high caffeine product as this passes into breast milk.
Some common side effects of this medicine include mild delirium, insomnia, frequent urge to urinate, dehydration, tachycardia, and fever. Consult your doctor if these do not go away or persist for a longer duration. They may be able to suggest ways to prevent or reduce the side effects.
Uses of Cafirate Injection
- Apnea of prematurity
Benefits of Cafirate Injection
In Apnea of prematurity
In a premature baby, the part of the brain that controls breathing is not mature enough for nonstop breathing. This causes large bursts of breath followed by periods of shallow breathing or stopped breathing. This is called apnea or breathing trouble of prematurity. Cafirate Injection helps to stimulate those areas of the brain that control breathing and normalise it. It is given as an injection by a doctor or nurse.
Side effects of Cafirate Injection
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Cafirate
- Delirium (acute confusional state)
- Dehydration
- Fever
- Insomnia (difficulty in sleeping)
- Frequent urge to urinate
How to use Cafirate Injection
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Cafirate Injection works
Cafirate Injection is a stimulant. It works by blocking the action of certain natural substances (adenosine and phosphodiesterase) leading to stimulation of the brain and respiratory system in premature newborns. This reduces the number of episodes of interrupted breathing and helps the newborns breathe on their own.
Safety advice
Alcohol
UNSAFE
It is unsafe to consume alcohol with Cafirate Injection.
Pregnancy
CONSULT YOUR DOCTOR
Cafirate Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
CAUTION
Cafirate Injection should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from her body.
Driving
UNSAFE
Cafirate Injection may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney
CONSULT YOUR DOCTOR
There is limited information available on the use of Cafirate Injection in patients with kidney disease. Please consult your doctor.
Liver
CONSULT YOUR DOCTOR
There is limited information available on the use of Cafirate Injection in patients with liver disease. Please consult your doctor.
What if you forget to take Cafirate Injection?
If you miss a dose of Cafirate Injection, please consult your doctor.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
Cafirate Injection
₹244/Injection
Capnea Injection
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₹267.5/injection
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Capnea Injection
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₹535.2/injection
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Cafneon 20mg/ml Injection
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₹262.5/injection
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Quick tips
- Cafirate Injection helps in the treatment of interrupted breathing in premature babies.
- It is given as an injection (drip) by your doctor or nurse.
- If you are breast-feeding while your infant is treated with Cafirate Injection, do not drink coffee or take any other high caffeine product as caffeine passes into breast milk.
Fact Box
Chemical Class
Xanthine Derivative
Habit Forming
No
Therapeutic Class
CARDIAC
Action Class
Adenosine receptor (A1 & A2) antagonist
Interaction with drugs
Taking Cafirate with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
It is recommended to avoid Caffeine for at least 24 hours before taking Adenosine. Please consult your doctor accordingly. Caffeine may reduce the efficacy of Adenosine.
If concurrent use is essential, watch out for symptoms such as acute confusional state, difficulty in sleeping, frequent urge to urinate or fever and consult your doctor if you exp
It is recommended to avoid Caffeine after taking Phenobarbitone, especially at bedtime. Caffeine may reduce the efficacy of Phenobarbitone.
Your doctor may monitor the effects of Leflunomide when taken concurrently with Caffeine. Caffeine may reduce blood levels of Leflunomide.
Talk to your doctor if you notice any unusual symptoms. Your doctor may adjust the dose if required.
Concomitant use may cause an increase in blood serotonin levels. Patients may
Patient concerns
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FAQs
What is Cafirate Injection and why is it used in newborns?
Cafirate Injection is a medicine given to premature babies who have apnea of prematurity. This condition causes infants to stop breathing for short periods because their breathing system is not fully developed. Cafirate Injection helps stimulate the baby’s brain and lungs to improve breathing.
How does Cafirate Injection work in premature babies?
Cafirate Injection works by stimulating the central nervous system and the baby’s breathing center. It makes the brain more responsive to carbon dioxide and helps reduce episodes where the baby stops breathing. It also improves muscle tone and decreases fatigue of the diaphragm, the muscle that controls breathing.
Who should not receive Cafirate Injection?
Cafirate Injection should not be given to infants who are allergic or hypersensitive to caffeine, or any of the ingredients in the medicine. If a baby has shown any allergic reaction to caffeine in the past, this medicine should be avoided.
What serious risks are linked with Cafirate Injection in newborns?
One of the most serious risks linked to Cafirate Injection is necrotizing enterocolitis (a life-threatening bowel condition) that has been reported in premature babies during clinical studies. Because of this, babies receiving this medicine must be closely monitored for abdominal bloating, vomiting, bloody stools, or sudden changes in energy levels.
Can Cafirate Injection be used for long-term treatment?
No, Cafirate Injection is meant only for short-term treatment of apnea of prematurity, typically for ten to twelve days. Its safety and effectiveness for long-term use, or for other conditions such as sudden infant death syndrome (SIDS), have not been proven.
What precautions should doctors take before giving Cafirate Injection?
Before starting Cafirate Injection treatment, doctors should rule out other possible causes of apnea, such as infections, anemia, or lung disease. They may also need to check caffeine levels in babies who were previously given theophylline, or whose mothers consumed caffeine before delivery, since these can affect blood caffeine levels.
What should caregivers watch for while their baby is on Cafirate Injection?
While the baby is on Cafirate Injection treatment, parents or caregivers should immediately contact the doctor if the baby develops a swollen belly, vomiting, bloody stools, unusual sleepiness, or seems unwell. These may be signs of serious complications such as necrotizing enterocolitis.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- O’Brien CP. Drug Addiction. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 663.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 179-83.
- Tulane University: School of Medicine. Caffeine. [Accessed 29 Jan. 2019] (online) Available from:
- Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Caffeine. [Updated 2019 Jun 30]. [Accessed 20 Feb. 2020] (online) Available from:
Marketer details
Name: Sun Pharmaceutical Industries Ltd
Address: Plot no 107/108,Namli block , Ranipool, East Sikkim 737135
Country of origin: India
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₹244
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