Aurocarpine 0.5% Injection

Reviewed By Dr. Mekhala Chandra, MD, MBBS

Last updated on 25 Nov 2025 | 03:05 PM (IST)

Aurocarpine 0.5% Injection is used in the treatment of dry mouth after radiotherapy of head and neck cancer. It works by reducing abnormal dryness of the mouth which makes speaking and swallowing easier.

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General Information

Contains

Pilocarpine (0.5% w/v)

Marketer

Aurolab

Storage

Store below 30°C

The content is shown in English

Product introduction

Aurocarpine 0.5% Injection must be administered by a healthcare professional in the hospital or in a clinical setting. You should not self administer this medicine at home.

The most common side effects of this medicine are headache, sweating, frequent urge to urinate, and flu syndrome. If you experience such symptoms that persist or worsen, or any other symptoms which you think may be due to this medicine, inform your doctor.

It is not advised to drive after using this injection as it may decrease your alertness and make you feel dizzy.

Uses of Aurocarpine Injection

Dry mouth after radiotherapy of head and neck cancer

Benefits of Aurocarpine Injection

Dry mouth after radiotherapy of head and neck cancer
Radiation therapy to the head, face, or neck may also cause dry mouth. It can take 6 months or longer after radiation therapy ends for the salivary glands to start producing saliva again. Aurocarpine 0.5% Injection helps to increase the secretions of body fluids, particularly saliva and this helps to improve dry mouth due to radiation therapy. It is given as an injection by a doctor or nurse and should not be self-administered.

Side effects of Aurocarpine Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Aurocarpine

Flu-like symptoms
Headache
Sweating
Frequent urge to urinate

How to use Aurocarpine Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Aurocarpine Injection works

Aurocarpine 0.5% Injection is a cholinergic agonist. It works by reducing abnormal dryness of the mouth that may occur in certain immune disorders or due to radiation therapy for head and neck cancer.

Quick tips

Inform your doctor if you have eye inflammation, suffer from asthma, liver, kidney or heart diseases, Parkinson’s disease, stomach ulcer, have problems in passing urine, high blood pressure, narrow angle glaucoma (increased eyeball pressure due to obstruction to the outflow of fluid).
Drink sufficient water to reduce dehydration due to excessive sweating caused by Aurocarpine 0.5% Injection.
The back layer of your eye (fundus) may be examined before starting Aurocarpine 0.5% Injection therapy.
Do not drive or operate machinery as Aurocarpine 0.5% Injection causes dizziness and blurring of vision especially in the night.
Tell your doctor if you are pregnant, planning to become pregnant or are breastfeeding.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Aurocarpine 0.5% Injection. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Aurocarpine 0.5% Injection during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CONSULT YOUR DOCTOR

Aurocarpine 0.5% Injection may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.

Driving

UNSAFE

Aurocarpine 0.5% Injection may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Aurocarpine 0.5% Injection should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

CAUTION

Aurocarpine 0.5% Injection should be used with caution in patients with liver disease. Dose adjustment may be needed.
Use of Aurocarpine 0.5% Injection is not recommended in patients with severe liver disease.

Interaction with drugs

Taking Aurocarpine with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Donepezil (Oral Route)

If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations.

Moderate

Galantamine (Oral Route)

If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations. Pilocarpine may increase the effect of Galantamine.

Moderate

Rivastigmine (Transdermal Route)

If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations.

Moderate

Rivastigmine (Oral Route)

If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations.

Moderate

Octreotide acetate (Injection Route)

If concurrent use is essential, your doctor may monitor cardiac function and may modify the doses if required.

Frequently asked questions

Does Aurocarpine 0.5% Injection increase or decrease heart rate?

Aurocarpine 0.5% Injection can decrease the heart rate. However, it does not increase the heart rate.

Does Aurocarpine 0.5% Injection cause weight gain/increase blood pressure?

Aurocarpine 0.5% Injection increases blood pressure. However, no clinically relevant effect on weight has been reported with the use of Aurocarpine 0.5% Injection.

Does Aurocarpine 0.5% Injection help dry eyes?

Yes, Aurocarpine 0.5% Injection helps dry eyes by increasing the production of tears.

Does Aurocarpine 0.5% Injection work?

Aurocarpine 0.5% Injection acts by increasing the activity of chemical acetylcholine, thereby, increasing the secretion from various glands including salivary glands and tear glands. Due to its cholinergic effect, it also constricts the pupil of the eye and improves the outflow of aqueous humor (fluid in within the eye) contributing to reduction in eyeball pressure.

Does Aurocarpine 0.5% Injection cause blurred vision/hair loss?

Yes, Aurocarpine 0.5% Injection causes blurred vision. But, it does not cause hair loss.

How does Aurocarpine 0.5% Injection affect heart rate?

Aurocarpine 0.5% Injection decreases heart rate by increasing the effect of a chemical called as acetylcholine.

How does Aurocarpine 0.5% Injection lower intraocular pressure?

Aurocarpine 0.5% Injection lowers intraocular pressure by constricting the ciliary muscle of the eyes, therefore increasing the outflow of fluid (aqueous humor) from posterior part of the eye.

Fact Box

Chemical Class

Alkaloid derivative

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Cholinomimetic Alkaloids- Pilocarpine

References

Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1120-21.
PubChem. Pilocarpine. [Accessed 04 Apr. 2019] (online) Available from:
Pilocarpine hydrochloride. Luxembourg: Merus Labs Luxco S.a.R.L.; 2001 [revised 01 Apr. 2016]. [Accessed 28 Jan. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 03 Apr. 2019] (online) Available from:
Pilocarpine Hydrochloride Ophthalmic Solution [Prescribing Information]. Fort Worth, TX: Alcon laboratories, Inc.; 2011. [Accessed 25 Jul. 2024] (online) Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Aurolab
Address: No: 1 , Sivagangai Main Road, Veerapanjan, Madurai - 625 020, Tamil Nadu, India.

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Aurocarpine 0.5% Injection

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Aurocarpine Injection

Benefits of Aurocarpine Injection

Side effects of Aurocarpine Injection

How to use Aurocarpine Injection

How Aurocarpine Injection works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Donepezil (Oral Route)

Galantamine (Oral Route)

Rivastigmine (Transdermal Route)

Rivastigmine (Oral Route)

Octreotide acetate (Injection Route)

Frequently asked questions

Does Aurocarpine 0.5% Injection increase or decrease heart rate?

Does Aurocarpine 0.5% Injection cause weight gain/increase blood pressure?

Does Aurocarpine 0.5% Injection help dry eyes?

Does Aurocarpine 0.5% Injection work?

Does Aurocarpine 0.5% Injection cause blurred vision/hair loss?

How does Aurocarpine 0.5% Injection affect heart rate?

How does Aurocarpine 0.5% Injection lower intraocular pressure?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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