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Alfadrops 0.5% Eye Drop

Apraclonidine (0.5%)
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Alfadrops 0.5% Eye Drop is used in the treatment of ocular hypertension (pressure in the eye) and glaucoma. It helps to lower high pressure in the eye by decreasing the production of fluid. This reduces the risk of vision loss.

Written By Dr. Anuj Saini, MMST, MBBS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 10 Aug 2026 | 10:53 AM (IST)
₹33.8 MRP ₹37.510% off 
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General Information

The content is shown in English
Alfadrops 0.5% Eye Drop image
Alfadrops 0.5% Eye Drop image

Product introduction

Alfadrops 0.5% Eye Drop is for external use only. Use it in the dose and duration as advised by the doctor. If you wear contact lenses, remove them before using the medication. Avoid touching the tip of the dropper to any surface as it may contaminate the eye drop.

For best results, use it daily in the evening or at night. The most common side effects of this medicine include itching and inflammation of eyes, watery eyes, eye inflammation, and dry eyes. You may also experience other side effects like headache, rhinitis, and dry mouth. If these side effects persist for a longer duration, inform your doctor. Do no drive right after using the medicine, as it may blur the eye for some time.

Uses of Alfadrops Eye Drop

Benefits of Alfadrops Eye Drop

Glaucoma
Alfadrops 0.5% Eye Drop is a medicine used to reduce pressure in your eyes (ocular hypertension). This pressure can lead to an illness called glaucoma. If the pressure in your eye is too high, it can damage your sight. This medicine works by helping the fluid to flow from inside the eye into your bloodstream. It may be used alone or with other eye drops. Do not use it too often as that can make it less effective. You should only use it in the affected eye and take it regularly as prescribed by your doctor. If you stop taking it, the pressure in your eye will not be controlled. This could lead to a loss of sight.
Ocular hypertension
Alfadrops 0.5% Eye Drop belongs to a group of medicines called prostaglandin analogue. It is used to reduce pressure in your eyes. It increases the flow of fluid from inside the eye into the bloodstream thereby lowering the increased eye pressure. If the pressure in your eye is too high, it can damage your sight. You should only use it in the affected eye and take it regularly as prescribed by your doctor. If you stop taking it, the pressure in your eye will not be controlled.

Side effects of Alfadrops Eye Drop

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Alfadrops
  • Eye itching
  • Conjunctivitis
  • Ocular hyperemia

How to use Alfadrops Eye Drop

This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Hold the dropper close to the eye without touching it. Gently squeeze the dropper and place the medicine inside the lower eyelid. Wipe off the extra liquid.

How Alfadrops Eye Drop works

Alfadrops 0.5% Eye Drop works by stimulating alpha-2 receptors, which reduces the production of aqueous humour (the fluid inside the eye) and also helps increase its outflow. This action lowers raised pressure inside the eye. It reduces intraocular pressure, helps protect the optic nerve.

Quick tips

  • Alfadrops 0.5% Eye Drop helps lower high pressure in the eye and reduces the risk of vision loss.
  • For best results, put one drop 2-3 times daily in the affected eye(s).
  • Apply pressure on the corner of the eye (close to the nose) for about 1 minute, immediately after instilling the drop.
  • Remove contact lenses before using Alfadrops 0.5% Eye Drop and allow at least 15 minutes before re-inserting them.
  • Do not touch the tip of the dropper to any surface, or to your eye, to avoid contaminating the eye drops.
  • Wait for at least 5-10 minutes before delivering the next medication in the same eye to avoid dilution.
  • It may cause short term blurring of vision when first used. Use caution before driving or using machines.
  • It may cause temporary burning or itching sensation in the eye. Inform your doctor if this does not go away.
  • Make sure to use within 4 weeks of opening the bottle.
  • Alfadrops 0.5% Eye Drop helps lower high pressure in the eye and reduces the risk of vision loss.
  • For best results, put one drop 2-3 times daily in the affected eye(s).
  • Apply pressure on the corner of the eye (close to the nose) for about 1 minute, immediately after instilling the drop.
  • Remove contact lenses before using Alfadrops 0.5% Eye Drop and allow at least 15 minutes before re-inserting them.
  • Do not touch the tip of the dropper to any surface, or to your eye, to avoid contaminating the eye drops.
  • Wait for at least 5-10 minutes before delivering the next medication in the same eye to avoid dilution.
  • It may cause short term blurring of vision when first used. Use caution before driving or using machines.
  • It may cause temporary burning or itching sensation in the eye. Inform your doctor if this does not go away.
  • Make sure to use within 4 weeks of opening the bottle.

Safety advice

Alcohol

Alcohol

No interaction found/established
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of Alfadrops 0.5% Eye Drop during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

CAUTION
Alfadrops 0.5% Eye Drop should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.
To reduce the amount of Alfadrops 0.5% Eye Drop that reaches the breastmilk, place pressure over the corner of the eye for 1 minute or more, then remove the excess solution with an absorbent tissue.
Driving

Driving

UNSAFE
Alfadrops 0.5% Eye Drop may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

No interaction found/established
Liver

Liver

No interaction found/established
All

Interaction with drugs

Taking Alfadrops with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Mild

Alfuzosin (Oral Route)

Monitor your blood pressure regularly and talk to your doctor if you notice persistently low blood pressure or its symptoms such as dizziness, fatigue, nausea, etc.
Mild

Amlodipine (Oral Route)

Monitor your blood pressure regularly and talk to your doctor if you notice persistently low blood pressure or its symptoms such as dizziness, fatigue, nausea, etc.
Mild

Atenolol (Oral Route)

Monitor your blood pressure regularly and talk to your doctor if you notice persistently low blood pressure or its symptoms such as dizziness, fatigue, nausea, etc.
Mild

Atenolol (Injection Route)

Monitor your blood pressure regularly and talk to your doctor if you notice persistently low blood pressure or its symptoms such as dizziness, fatigue, nausea, etc.
Mild

Benazepril (Oral Route)

Monitor your blood pressure regularly and talk to your doctor if you notice persistently low blood pressure or its symptoms such as dizziness, fatigue, nausea, etc.

Frequently asked questions

Ideally, you should use the drops regularly, three times a day, or as prescribed by your doctor.
When you instill the eye drops for the first time, it can make your eyes watery and may sometimes cause blurred vision. If this happens, it will quickly clear. Make sure you can see clearly again before you drive, or use tools or machines.
Yes, headache is a common side-effect of Alfadrops 0.5% Eye Drop. You may ask your doctor to recommend a suitable painkiller. If the headache continues, speak with your doctor.
You should contact your doctor immediately if you develop an eye infection, conjunctivitis, or an eyelid reaction. Also, you should inform the doctor if you have an eye injury or eye surgery. Discuss with your doctor if you have to continue using Alfadrops 0.5% Eye Drop.
No, you should remove your contact lenses before instilling Alfadrops 0.5% Eye Drop. You can re-insert the lens 15 minutes after using Alfadrops 0.5% Eye Drop. Contact your doctor if there is any eye irritation that persists.
Always consult your doctor before using any other eye drops along with Alfadrops 0.5% Eye Drop. It is advisable to give a gap of atleast 10-15 minutes between the two medications.
Use of Alfadrops 0.5% Eye Drop should be avoided in patients who are allergic to it or any of its components. However, if you are not aware of any allergy or if you are using this medicine for the first time, consult your doctor.
You do not need to refrigerate Alfadrops 0.5% Eye Drop after opening the bottle. However, store it in a cool place and below 30℃. Make sure to use it within 4 weeks of opening the bottle.

Fact Box

Chemical Class

Dichlorobenzenes

Habit Forming

No

Therapeutic Class

OPHTHAL

Action Class

Ocular Sympathomimetics

References

  1. Westfall TC, WestfallIn DP. Adrenergic Agonists and Antagonists. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 297.
  2. Biaggioni I, Robertson D. Adrenoreceptor Agonists & Sympathomimetic Drugs. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 144.
  3. ScienceDirect. Apraclonidine. [Accessed 04 Apr. 2019] (online) Available from:
  4. Central Drugs Standard Control Organisation (CDSCO). [Accessed 04 Apr. 2019] (online) Available from:
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Cipla Ltd
Address: Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013

Vendor Details

Country of origin: India
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