Aklief Cream

Trifarotene (50mcg/gm)

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Aklief Cream is a medicine used in the treatment of acne. It works by decreasing the swelling and inflammation caused by acne. This way it reduces the severity of pimples and speeds up the healing process.

Written By Dr. Syeda Aafia, MBA, BDS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 23 Aug 2026 | 01:06 AM (IST)

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General Information

Contains

Trifarotene (50mcg/gm)

Marketer

Galderma India Pvt Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Aklief Cream is for external use only. Read the instructions and use it exactly as your doctor prescribed. Use it only on the affected areas and do not apply on healthy skin. Clean and dry the affected area before applying the medicine. Wash your hands thoroughly before and after application. Use it regularly to get the maximum benefits. You can help this medication work better by keeping the affected areas clean.

Common side effects of this medicine include irritation and itching at the site of application and sunburn. These are usually temporary and usually resolve with time. Consult your doctor if these side effects persist for a longer duration. Avoid direct contact of the cream or ointment with your eyes. In case of direct contact, wash your eyes with water and seek immediate medical attention.

Avoid sun exposure and cover the treated areas with clothing or use a sunscreen before stepping out in the sun. Before taking this medicine, you should tell your doctor if you are pregnant, planning pregnancy or breastfeeding to make sure it is safe for you.

Uses of Aklief Cream

Treatment of Acne

Benefits of Aklief Cream

Treatment of Acne
Aklief Cream helps treat acne (commonly called pimples) by reducing inflammation and targeting other important factors that cause acne. It may take a few weeks to have a noticeable effect so keep using it even if it appears not to be working. Sometimes acne may get worse before it gets better, however, with proper use, your skin will get clearer. The earlier you start using it, the less likely you are to get scars. This medicine will help improve your mood and uplift your confidence as your skin becomes acne free.

Side effects of Aklief Cream

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Aklief

Application site irritation
Application site itching
Sunburn

How to use Aklief Cream

This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the cream. Wash your hands after applying, unless hands are the affected area.

How Aklief Cream works

Aklief Cream works by specifically targeting the retinoic acid receptor gamma (RAR-γ) receptor present in the skin, to reduce inflammation and target other important factors that cause acne. The exact process by which Aklief Cream mitigates acne is unknown.

Quick tips

Aklief Cream is applied on the skin to treat acne.
Avoid using Aklief Cream on skin areas with cuts, abrasions, eczema, or on sunburned skin.
Apply a thin layer of Aklief Cream over the affected areas one time each day, in the evening or as recommended by your doctor.
Minimize exposure to sunlight.
Avoid the use of “waxing” as a hair removal method on skin treated with Aklief Cream.
Breastfeeding women should not apply Aklief Cream to the nipple and areola to avoid contact with your baby.

Safety advice

Alcohol

No interaction found/established

Pregnancy

UNSAFE

Aklief Cream is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.

Breast feeding

SAFE IF PRESCRIBED

Aklief Cream may be safe to use during breastfeeding. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

Driving

No interaction found/established

Kidney

No interaction found/established

Liver

No interaction found/established

Frequently asked questions

What is Aklief Cream used for?

Aklief Cream is used on the skin to treat acne (acne vulgaris) in people 9 years of age and older. It helps clear pimples, blackheads, and whiteheads on the face, chest, shoulders, and back.

When should I not use Aklief Cream?

There are no known absolute contraindications, but you should not use Aklief Cream if you are allergic to trifarotene or any of its ingredients. Always check the ingredient list, and talk to your doctor before use if you have sensitive skin or past allergic reactions to retinoids.

Can Aklief Cream cause skin irritation or redness?

During the first few weeks of Aklief Cream use, some patients may notice redness, dryness, scaling, or a burning/stinging sensation. This is common, and often improves as your skin adjusts. Using a gentle moisturizer and avoiding over-application can help reduce irritation.

What should I do if my skin becomes too irritated after applying Aklief Cream?

After applying Aklief Cream, if your skin feels very dry or irritated, you can apply a moisturizer regularly, use Aklief Cream less often (for example, every other night), and temporarily stop using it if irritation continues. Contact your doctor if symptoms are severe or do not improve.

Can I go out in the sun while using Aklief Cream?

You should avoid too much sun exposure while using Aklief Cream. This medicine can make your skin more sensitive to sunlight and sunburn. Always use sunscreen, wear protective clothing, and avoid sunlamps or tanning beds.

What serious side effects of Aklief Cream should I watch out for?

Although they are rare, serious side effects of Aklief Cream may include severe redness, swelling, or blistering, signs of an allergic reaction (itching, rash, hives, swelling), and pain, or worsening of acne over time. Reach out to your doctor immediately if you experience any of these symptoms.

Can teenagers and pre-teens use Aklief Cream?

Yes. Aklief Cream has been shown to be safe and effective for children aged 9 years and above. It should be used under medical supervision, especially for younger users.

How long does it take to see results with Aklief Cream?

The exact time Aklief Cream takes to show improvement in acne is not known. However, visible improvements often appear after 8 to 12 weeks of regular use. Some people may see early changes sooner, but full results take consistent use as directed.

What should I avoid while using Aklief Cream?

While using Aklief Cream, you should avoid overexposure to sunlight or UV lamps, applying to cuts or irritated skin, waxing treated areas (it can cause skin damage), and using strong exfoliants or acne peels without medical advice.

Fact Box

Chemical Class

M- terphenyls

Habit Forming

Therapeutic Class

DERMA

References

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Galderma India Pvt Ltd
Address: Lotus Corporate Park, D Wing Unit 801\802 , Off Western Express Highway, Goregaon (East), Mumbai 400 063, India.

Vendor Details

Country of origin: France

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Derma

Topical Anti Acne Preparations

Aklief Cream

Aklief Cream

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Aklief Cream

Benefits of Aklief Cream

Side effects of Aklief Cream

How to use Aklief Cream

How Aklief Cream works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Frequently asked questions

What is Aklief Cream used for?

When should I not use Aklief Cream?

Can Aklief Cream cause skin irritation or redness?

What should I do if my skin becomes too irritated after applying Aklief Cream?

Can I go out in the sun while using Aklief Cream?

What serious side effects of Aklief Cream should I watch out for?

Can teenagers and pre-teens use Aklief Cream?

How long does it take to see results with Aklief Cream?

What should I avoid while using Aklief Cream?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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