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MD (Pharmacology), MBBS
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20 Feb 2020 | 07:19 PM (IST)
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Afinitor 5mg Tablet

Prescription Required
Manufacturer
SALT COMPOSITION
Storage
Store at room temperature (10-30°C)

Overview

Introduction

Afinitor 5mg Tablet is used for the prevention of organ rejection in transplant patients. It regulates the body’s immune response, so the body can accept the new organ. It is also used in combination with other medicines to treat cancers of breast, pancreas, lungs and kidney.

Afinitor 5mg Tablet must be taken in a dose and duration as per the prescription. It can be taken with or without food but make sure to take it at about the same time every day. An overdose of this medicine may have serious side effects on the body.

The common side effects of this medicine are weakness, sinus inflammation, infection, fever, cough, etc. If any of the side effects persist or bother you, consult the doctor immediately. Inform the doctor immediately if you experience any allergic reactions (rash, shortness of breath, coughing, swelling, etc.). Always seek medical advice if you have increased thirst or increased frequency of urination, suffer from shortness of breath, cough or fever, or need to receive any vaccination after taking this medication.

Before taking this medicine, it is important to consult your doctor if you have any ongoing medication for any underlying disease. Pregnant and breastfeeding women must inform the doctor prior to the initiation of this treatment. During the treatment, your doctor may advise you for some laboratory tests to know the effects of the medicine in the body. It may affect male or female fertility, so consult the doctor if you are planning to have a child.

Side effects of Afinitor Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Afinitor

  • Weakness
  • Sinus inflammation
  • Infection
  • Fever
  • Cough
  • Fatigue
  • Stomatitis (Inflammation of the mouth)
  • Otitis media (infection of ear)
  • Diarrhea
  • Upper respiratory tract infection

How to cope with side effects?

The occurrence of side effects varies from person to person. The following are a few ways of dealing with some of the common side effects. However, consult your doctor if these persist.

  • Coping with Weakness and Fatigue
    Make sure you rest and drink plenty of fluids. Eat a well-balanced diet to keep your energy levels up. Do not drink too much alcohol. Do not drive or use tools or machinery until you feel better. Other things that can help include doing some gentle exercise every day, prioritizing and pacing your activities and having a short nap if you need to. If you are still having problems after a week, speak to your doctor, as they may want to change you to a different type of medicine.
  • Coping with Infection
    If you have a low level of white blood cells, you are more likely to get infections. There are several ways to reduce your chances of catching or spreading an infection. Avoid unnecessary exposure to germs when you can. Wash your hands frequently and thoroughly with soap or use a sanitiser. Avoid crowds and avoid contact with people who are ill or have infections. Use disposable tissues for coughs and sneezes. Consider using an appropriate face mask. Do not share personal items like cutlery, glasses, towels or toothbrushes with others. Get enough rest and eat a well balanced healthy diet.
  • Coping with Cough
    Get plenty of rest as exhausting or stressing out yourself could aggravate your condition. You should drink plenty of fluids as it will keep your throat moist and comfortable. Try taking steam inhalation. The moisture can ease your breathing and loosen mucus. You can consider sipping warm water or tea with honey and lemon. This will keep your nose and throat from being too dry. Using an air humidifier may also help. You can also gargle with salt water several times a day. See your doctor if your symptoms last longer than 3 weeks or get worse quickly. Avoid alcohol and do not smoke as they can aggravate your conditions.
  • Coping with Diarrhea
    Keep up your intake of fluids and electrolytes (sugars and salts) to avoid getting dehydrated. Eat less fiber (avoid raw fruits, fruit juice and vegetables). Talk to your doctor about possible medication to manage diarrhea. Ask about reducing the dosage of your drug or other suitable treatments.

How to use Afinitor Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Afinitor 5mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Afinitor Tablet works

Afinitor 5mg Tablet suppresses the activity of body's immune system and prevents rejection of the transplanted organ.

Safety Advice

Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Afinitor 5mg Tablet. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Afinitor 5mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breastfeeding
CONSULT YOUR DOCTOR
Afinitor 5mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
UNSAFE
Afinitor 5mg Tablet may cause side effects which could affect your ability to drive.
As fatigue is a common side effect with Afinitor 5mg Tablet and this may affect your ability to drive
Kidney
SAFE IF PRESCRIBED
Afinitor 5mg Tablet is safe to use in patients with kidney disease. No dose adjustment of Afinitor 5mg Tablet is recommended.
Liver
CAUTION
Afinitor 5mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Afinitor 5mg Tablet may be needed. Please consult your doctor.
Use of Afinitor 5mg Tablet is not recommended in patients with severe liver disease.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Afinitor 5mg Tablet
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Quick Tips

  • Do not start everolimus and consult your doctor if you have liver problems, diabetes, high blood cholesterol, had a recent surgery or have unhealed wound after surgery, have infection, previously had hepatitis, are pregnant or breast-feeding or have intolerance to some sugars.
  • Seek medical advice if you have increased thirst or increased frequency of urination, if you get any infection, suffer from shortness of breath, cough or fever, need to receive any vaccination after taking everolimus.
  • Everolimus may affect male or female fertility; consult your doctor if you are planning to have a child.
  • Do not drive or operate machinery while taking everolimus as it may cause fatigue.

Fact Box

Chemical Class
Macrolide Lactams
Habit Forming
No

Patient Concerns

arrow
I want to know the symptoms of cancer as I am a smoker
Dr. Vijay Sharnangat
Medical Oncology and Hematology
Symptoms for cancer depends upon which organ involved. For smokers , definitely chronic , they have possibility to develop lung cancer, head and neck cancers, oesophagus cancer, pancreatic cancer, stomach cancer and so more on. General symptoms would be like loss of appetite, weight loss, low grade fever in some cases, chronic cough for long time.
If any symtom of brest cancer if have whats the cure
Dr. Sanjay Singh Rai
Medical Oncology and Hematology
First is confirmation of breast cancerChance of cure depends on stage of cancer
arrow
Do you have any questions related to Afinitor 5mg Tablet ?

User Feedback


FAQs

Q. Is any monitoring required while taking Afinitor?

Regular monitoring is required while you are on Afinitor. The doctor will advise blood tests to see the counts of red blood cells, white blood cells, and platelets since the counts may decrease during treatment with Afinitor. Also, blood tests will be required to check your kidney function, liver function, blood glucose levels, and cholesterol levels.

Q. What should I avoid while taking Afinitor?

You should avoid grapefruit or grapefruit juice while taking Afinitor. This is because taking them together may increase the levels of Afinitor in your blood to harmful levels. Avoid the use of live vaccinations and any possible contact with individuals who have received live vaccinations.

Q. What is the most important information I need to know about Afinitor?

Afinitor can cause serious side effects which include severe allergic reactions, angioedema, and kidney failure which can be severe and can lead to death. It is possible that you may develop an infection or problems related to lung such as breathing problems.

Q. Is Afinitor a chemotherapy?

Afinitor is an anticancer medicine. It belongs to kinase inhibitor class of medicines. It works by reducing the blood supply to the tumor, which slows down the growth and spread of cancer cells.

Q. How is Afinitor administered?

Usually, Afinitor is taken once or twice daily. The medicine should always either be taken with food or always be taken without food. Afinitor should be swallowed whole with water and should not be crushed or chewed.

Q. How long can you take Afinitor?

There is no definite duration of treatment with Afinitor. Afinitor is continued till clinical benefit is seen or unacceptable toxicity or side effects occur.

Q. How will I know that Afinitor is shrinking my brain tumor?

The effect of Afinitor in shrinking the size of tumor can only be checked by getting regular brain scans. It should be done as advised by your doctor and your treatment plan.

Q. Is Afinitor cytotoxic?

Yes, Afinitor is cytotoxic against human cancer cells of breast, stomach, prostate, and kidneys (renal cell carcinoma).

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Disclaimer:

1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Krensky AM, Bennett WM, Vincenti F. Immunosuppressants, Tolerogens, and Immunostimulants. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. New York, New York: McGraw-Hill Medical; 2011. p. 1013.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 526.
  3. Everolimus. East Hanover, New Jersey: Novartis Pharmaceuticals Corporation; 2009 [revised Apr. 2018]. [Accessed 06 Apr. 2019] (online) Available from:External Link
  4. Everolimus. Camberley, Surrey: Novartis Pharmaceuticals UK Ltd.; 2011 [revised 12 Jul 2018]. [Accessed 22 Jan. 2019] (online) Available from:External Link

Manufacturer/Marketer Address

Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India
36527
MRP60146.43  39% OFF
10 tablets in 1 strip
SOLD OUT

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