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Vasculitis Panel

Also referred as

Vasculitis profile

Vasculitis blood tests

c-ANCA

p-ANCA

anti-GBM by LIA

For men & women

Earliest reports in

48 hours

Contains

3 tests

Know more about this test

The Vasculitis Panel is tailored to assess various forms of vasculitis, an inflammation of the blood vessels. This profile includes tests for specific autoantibodies and markers, such as PR3, MPO, and GBM, which are essential for diagnosing, differentiating and managing types of vasculitis.

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Understanding Vasculitis Panel

Vasculitis encompasses a range of disorders characterized by inflammation of blood vessels, which can cause significant damage to various organs and tissues throughout the body. The inflammation caused by vasculitis can result in symptoms ranging from mild, such as fever and fatigue, to severe, including organ dysfunction and life-threatening complications. Given the diverse nature and potential severity of vasculitis, accurate diagnosis and effective management are critical for improving patient outcomes.

The Vasculitis Panel is crucial for diagnosing, managing, and monitoring vasculitis through a series of specialized blood tests that identify specific autoantibodies and biomarkers linked to various types of vasculitis. This profile includes tests for PR3 (Proteinase 3), MPO (myeloperoxidase anti-neutrophil cytoplasmic antibodies), and GBM (glomerular basement membrane antibodies). PR3 and MPO are key in diagnosing ANCA-associated vasculitides (AAV), such as granulomatosis with polyangiitis (formerly Wegener's granulomatosis) and microscopic polyangiitis, with elevated levels indicating these conditions, guiding treatment decisions and monitoring disease progression. On the other hand, GBM antibodies are associated with Goodpasture syndrome, which affects the kidneys and lungs. Detecting GBM antibodies helps confirm this diagnosis and helps formulate treatment strategies. Effective management may involve immunosuppressive therapies and regular monitoring to assess treatment response and disease progression.

No special preparation is required for this panel. However, it is crucial to inform your doctor about any medications or supplements you are taking, as they might affect test results.

Lab test results may vary across different laboratories. Abnormal test results require an expert interpretation, therefore, never try to self-medicate at home based solely on these results, and always consult a doctor for proper understanding of the test results.

What does Vasculitis Panel measure?

Contains 3 tests

The Vasculitis Panel measures specific biomarkers to help diagnose and manage vasculitis. It includes tests for Proteinase 3 (PR3), where elevated levels are associated with granulomatosis with polyangiitis (Wegener's granulomatosis) and other ANCA-associated vasculitides; Myeloperoxidase Anti-Neutrophil Cytoplasmic Antibodies (MPO) test, with elevated levels indicating conditions such as microscopic polyangiitis and other ANCA-associated vasculitides; and Glomerular Basement Membrane Antibodies (GBM), whose presence suggests Goodpasture syndrome, a condition affecting both the kidneys and lungs. By evaluating these specific biomarkers, the vasculitis panel provides crucial insights into the presence, type, and activity of vasculitis, enabling the development of targeted and personalized treatment strategies to manage the disease effectively.

PR3

The PR3, also known as the Proteinase 3 (PR3) antibody test, measures the presence of antibodies directed against proteinase 3, which is an enzyme found in neutrophils (a type of white blood cell). The presence of these antibodies are often associated with autoimmune conditions, particularly granulomatosis with polyangiitis (GPA), a form of vasculitis. Elevated PR3 antibody levels can indicate active disease and may help in monitoring both the progression of the condition and the response to treatment.

Know more about PR3

MPO

The MPO (Myeloperoxidase Anti-Neutrophil Cytoplasmic Antibodies) test detects autoantibodies against myeloperoxidase (MPO), an enzyme found in neutrophils (a type of white blood cell). These autoantibodies, called anti-MPO antibodies, are associated with autoimmune diseases like Vasculitis, especially Granulomatosis with Polyangiitis (GPA) and Microscopic Polyangiitis (MPA). A positive result is commonly seen in these types of vasculitis, aiding in diagnosis and treatment planning. The test is especially useful for differentiating GPA and MPA from other vasculitis forms, providing valuable insight for effective management.

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GBM

The GBM, (Glomerular Basement Membrane) test detects antibodies against the glomerular basement membrane, associated with Goodpasture's Syndrome, an autoimmune disorder affecting the kidneys and lungs. A positive result indicates the presence of antibodies that damage kidney tissue, leading to glomerulonephritis or pulmonary hemorrhages. The test is crucial for diagnosing Goodpasture’s Syndrome, distinguishing it from other kidney conditions, and guiding treatment to prevent further organ damage.

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FAQs related to Vasculitis Panel

What is the Vasculitis Panel?

The Vasculitis Panel is a set of blood tests used to detect specific autoantibodies associated with different types of vasculitis. It typically includes tests for PR3-ANCA, MPO-ANCA, and GBM antibodies, which help diagnose and manage various forms of vasculitis.

Why would I need the Vasculitis Panel?

You may need the Vasculitis Panel if you have symptoms suggestive of vasculitis, such as unexplained fever, weight loss, joint pain, skin rashes, or respiratory issues. It is also used to monitor disease activity or response to treatment in individuals already diagnosed with vasculitis.

How should I prepare for the test?

No special preparation is needed for the Vasculitis Panel. Follow your doctor’s instructions, and inform them of any medications or supplements you are taking, as these might affect test results.

What does each test in this panel measure?

The Vasculitis Panel includes PR3-ANCA (Anti-Proteinase 3 Antibody) test that detects antibodies against proteinase 3, with elevated levels potentially indicating Granulomatosis with Polyangiitis (GPA); MPO-ANCA (Anti-Myeloperoxidase Antibody) test that measures antibodies against myeloperoxidase, which are commonly linked to Microscopic Polyangiitis (MPA) and GBM Antibodies (Glomerular Basement Membrane) test to identify antibodies against the glomerular basement membrane, a marker that can suggest Goodpasture’s Syndrome.

What does a positive result mean?

A positive result for PR3-ANCA may indicate Granulomatosis with Polyangiitis, while a positive MPO-ANCA result is suggestive of Microscopic Polyangiitis or other small-vessel vasculitides. A positive GBM Antibodies result supports a diagnosis of Goodpasture’s Syndrome. However, it is important to interpret positive results in conjunction with clinical symptoms and other diagnostic findings for a comprehensive assessment.

What does a negative result mean?

A negative result means that the specific antibodies tested for were not detected. However, this does not completely rule out vasculitis, as some patients with vasculitis may test negative for these specific antibodies. Further testing or clinical evaluation may be necessary.

Are there any risks or side effects associated with the test?

No, the Vasculitis Panel is generally safe with minimal risks. However, you may feel slight discomfort during blood sample collection but chances of serious complications are extremely rare.

How often should I have the Vasculitis Panel tested?

The frequency of testing depends on your individual health condition, disease progression, and treatment plan. Your healthcare provider will determine the appropriate intervals for testing based on your specific situation.

Can this panel diagnose all types of vasculitis?

The Vasculitis Panel is useful for diagnosing certain types of vasculitis, such as Granulomatosis with Polyangiitis, Microscopic Polyangiitis, and Goodpasture’s Syndrome. It may not detect all forms of vasculitis, so additional testing and clinical evaluation may be necessary for a comprehensive diagnosis.

How does Tata 1mg ensure accurate lab test results?

Tata 1mg ensures accurate lab test results through certified laboratories that use advanced technology and adhere to stringent quality control measures. This commitment to high standards guarantees reliable results.

Content created by

Dr. Swati Gupta (Anand)

MBBS, MD Lab Medicine

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Last Updated

16th Dec 2025