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Protein Electrophoresis, Serum

Protein Electrophoresis, Serum

Also referred as
Serum protein electrophoresis
Protein electrophoresis
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For men & women
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The Protein Electrophoresis, Serum test checks different proteins in the blood. It sorts proteins by size and electrical charge to help find health problems like infections, liver/kidney issues, or certain types of cancer.

 

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Understanding Protein Electrophoresis, Serum

The Protein Electrophoresis, Serum test checks the different proteins in the blood to help diagnose health problems. The blood contains important proteins like albumin (which carries nutrients) and globulins (which help fight infections).

During the test, a small blood sample is placed on a special gel, and an electric current separates the proteins into groups based on their size and charge. Doctors then look at these groups to spot unusual patterns, like too much of one protein or missing proteins. This test helps diagnose conditions such as multiple myeloma (a type of blood cancer), liver or kidney disease, and long-term infections. 

The test might be needed if there are symptoms like constant tiredness, swelling, or unexplained weight loss, or if other blood tests show abnormal protein levels. 

No special preparation is required for this test. Tell the doctor about any medicines being taken, as they could affect the results. 

Test result ranges are approximate and may differ slightly between labs. The doctor will explain what the results mean and whether further tests or treatment are needed.

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What does Protein Electrophoresis, Serum measure?

The Protein Electrophoresis, Serum test measures the concentration and distribution of specific proteins (like albumin, alpha globulins, beta globulins, and gamma globulins) in the blood. Each of these plays a vital role in bodily functions. This test aids in the detection of abnormal proteins, particularly monoclonal (M) proteins. The presence of M proteins may indicate plasma cell disorders such as multiple myeloma (a blood cancer that affects plasma cells in the bone marrow). Also, this test helps diagnose and monitor various blood disorders.

FAQs related to Protein Electrophoresis, Serum

The Protein Electrophoresis, Serum test is a blood test used to separate and measure different proteins in the blood. It helps identify and quantify specific proteins, including albumin, globulins, and immunoglobulins.
Your doctor may order this test to diagnose or monitor conditions that affect protein levels, such as multiple myeloma, Waldenström's macroglobulinemia, amyloidosis, liver disease, kidney disease, or nutritional imbalances. It may also be used to track the effectiveness of treatments for certain conditions.
No special preparation is typically required for this test. However, let your doctor know about any medications, supplements, or health conditions you have, as they may impact the results.
The test is done by taking a blood sample from a vein in your arm. The sample is then analyzed in a lab, where proteins are separated based on their size, shape, and charge.
No fasting is required before this test. You can eat and drink as usual unless otherwise instructed by your healthcare provider.
The Protein Electrophoresis, Serum test is a normal blood test and carries minimal risk. You may feel slight discomfort, bruising, or swelling at the blood draw site.
The test results show the concentration and distribution of different protein fractions. Abnormal levels may suggest conditions like multiple myeloma, liver or kidney disease, inflammation, or malnutrition. Your doctor will interpret the results based on your health and symptoms.
The test can detect protein abnormalities that may suggest cancers like multiple myeloma, but it’s not a definitive cancer test. Further tests may be needed for a full diagnosis.
Additional tests may also be needed, including urine protein electrophoresis, serum immunofixation, bone marrow biopsy, immunotyping to identify the type of M proteins present, complete blood count, blood calcium and electrolyte tests, and kidney and liver function tests.
Tata 1mg ensures accurate lab test results through certified laboratories. Tata 1mg uses advanced technology and adheres to stringent quality control measures. This commitment to high standards guarantees reliable results.
Content created by
Written by:
Shweta Prakash
MSc, BSc
Reviewed by:
Dr. Hitesh Tiwari
MD Pathology, MBBS
Want to know moreRead our editorial policy
Last Updated8th Dec 2025

Protein Electrophoresis, Serum test price for other cities

Price inBangaloreRs. 919
Price inKolkataRs. 719
Price inNew DelhiRs. 719
Price inMumbaiRs. 989
Price inPuneRs. 769

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Contains 1 test
Protein Electrophoresis, Serum