An HIV Combo (Antigen And Antibody) Test simultaneously detects HIV p24 antigen and antibodies associated with HIV 1 & 2. The HIV p24 antigen is the most abundant HIV protein. Its detection is used clinically to diagnose an HIV infection early on since HIV-specific antibodies are not detectable in a very recently acquired infection.
HIV-1 was discovered first and is the most widespread. HIV-2 is more than 55% genetically different from HIV-1. The transmission rate of HIV-2 is also slower than HIV-1.
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