
Herpes Simplex Virus 1 & 2, IgG









The Herpes Simplex Virus 1 & 2, IgG test is performed to confirm if a person has been previously exposed to herpes simplex virus (HSV) 1 & 2 which causes herpes infection. It does so by detecting the presence of IgG antibodies (specific proteins) that are produced in response to a past or prolonged infection. Getting tested helps manage herpes infection and prevent it from spreading further.













Understanding Herpes Simplex Virus 1 & 2, IgG
Herpes simplex virus (HSV), known as herpes, causes infections related to the skin. Herpes is highly contagious and can be spread through sexual contact or skin-to-skin contact with an infected person. The infection lasts a lifetime, and it causes painful or itchy sores and blisters that come and go. While herpes is not curable, it can be well managed with medicines.
Herpes can be of two types based on the types of herpes simplex virus which are HSV-1 or HSV-2. HSV-1 is commonly known as oral herpes which usually causes cold sores and blisters on your mouth or the face. It can spread through contact with saliva such as kissing. On the other hand, HSV-2 can lead to genital herpes as it is usually transmitted through sexual contact. However, either type can infect any area of the body.
Most individuals with herpes have no symptoms or experience only mild symptoms. While many individuals do not know that they have herpes infection, they may unknowingly pass the virus on to others. Those who exhibit symptoms may experience painful, recurring blisters or ulcers, fever, body aches, sore throat, and swollen lymph nodes. Symptoms may also be different during the first episode (outbreak) of infection than during a recurrent episode.
Your doctor may recommend the Herpes Simplex Virus 1 & 2, IgG test when you are experiencing symptoms suggestive of herpes infection. This test checks for the presence of IgG antibodies against HSV-1 and HSV-2 that your body produces in response to the viral infection. Usually, no specific preparation is needed to get this test done. You can eat and drink normally before the test.
Talk to your doctor about your specific test results. Narrate your complete medical history and symptoms to help them correlate your clinical and laboratory findings and formulate your treatment plan. Negative results may not exclude an eventual infection, in case of equivocal results, a repeat test is recommended after 8-14 days.
What does Herpes Simplex Virus 1 & 2, IgG measure?
The Herpes Simplex Virus 1 & 2, IgG test determines the presence of IgG antibodies against HSV-1 and HSV-2 in response to the Herpes infection. Your body begins to make two relevant types of HSV-1 antibody or HSV-2 antibody around 18 to 21 days after you are exposed to the virus and remains in the body for life. The presence of IgG antibodies generally indicates past exposure and immunity against Herpes infection.





FAQs related to Herpes Simplex Virus 1 & 2, IgG
- Genital Herpes – CDC Basic Fact Sheet [Internet]. CDC; 03 Jan. 2022 [Accessed 18 Jan. 2024]. Available From:
- Genital Herpes Screening FAQ [Internet]. CDC; 11 Jul. 2022 [Accessed 18 Jan. 2024]. Available from:
- Herpes simplex virus [Internet]. WHO; 05 Apr. 2023 [Accessed 18 Jan. 2024]. Available from:
- Tada DG, Khandelwal N. Serum HSV-1 and 2 IgM in Sexually Transmitted Diseases - More for Screening Less for Diagnosis: An Evaluation of Clinical Manifestation. J Glob Infect Dis. 2012 Jul;4(3):S1-4. [Accessed 18 Jan. 2024]. Available from:
- Nath P, Kabir MA, Doust SK, Ray A. Diagnosis of Herpes Simplex Virus: Laboratory and Point-of-Care Techniques. Infect Dis Rep. 2021 Jun 2;13(2):518-539. [Accessed 18 Jan. 2024]. Available from:
- Saleh D, Yarrarapu SNS, Sharma S. Herpes Simplex Type 1. [Updated 2023 Aug 28]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from:
- Sauerbrei A. Herpes Genitalis: Diagnosis, Treatment and Prevention. Geburtshilfe Frauenheilkd. 2016 Dec;76(12):1310-1317. [Accessed 18 Jan. 2024]. Available from:
- Katz D, Hilliard JK, Mirkovic RR, Word RA. ELISA for detection of IgG and IgM antibodies to HSV-1 and HSV-2 in human sera. J Virol Methods. 1986 Aug;14(1):43-55. [Accessed 18 Jan. 2024]. Available from:
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