Scl-70 Antibody near me in Mumbai

The Scl-70 Antibody test detects anti-topoisomerase I antibodies in the blood. These autoantibodies target topoisomerase I, an enzyme essential for unwinding DNA during cell replication. Their presence indicates an autoimmune reaction, where the immune system mistakenly attacks the body’s own tissues.

SCL-70 antibodies are found in about 40% of patients with progressive systemic sclerosis (PSS). A positive result suggests a higher likelihood of systemic sclerosis, particularly the diffuse cutaneous type, which is more often associated with lung and internal organ involvement. However, not all patients with systemic sclerosis test positive for SCL-70 antibodies, and in some cases, these antibodies may also appear in other connective tissue diseases. A negative result does not rule out systemic sclerosis but makes the diagnosis less likely. Results must always be interpreted in combination with symptoms, physical findings, and other laboratory and imaging studies, not standalone.