
PNH by FLAER- High Sensitivity near me in Agra







The PNH by FLAER- High Sensitivity test is an advanced flow cytometry test that aids in diagnosing Paroxysmal Nocturnal Hemoglobinuria (PNH), a rare blood disorder resulting from a genetic mutation that affects blood cell membranes. This test detects even tiny populations of abnormal cells, allowing early diagnosis and accurate monitoring of disease progression and treatment response. It is widely available with Tata 1mg labs at an affordable price in Agra. This high-sensitivity test can find even very small numbers of PNH cells, which helps in early diagnosis, monitoring the disease, and checking how well treatment is working.








What does PNH by FLAER- High Sensitivity measure?
The PNH by FLAER- High Sensitivity test measures the presence and proportion of blood cells lacking specific surface proteins that protect them from destruction by the immune system. It helps detect the PNH clone, a population of abnormal red and white blood cells missing certain protective proteins due to a mutation in the PIGA gene.
Using flow cytometry, the test analyzes multiple markers on different blood cell types:
- WBC (White Blood Cells): FLAER, CD45, CD24, CD15, CD33, CD64, and CD14
- RBC (Red Blood Cells): CD59 and CD235a
These markers help identify cells deficient in glycosylphosphatidylinositol (GPI)-anchored proteins, a hallmark of PNH. A significant proportion of GPI-deficient cells confirms the diagnosis. The test also aids in evaluating patients with unexplained hemolysis, thrombosis, or bone marrow failure disorders like aplastic anemia or myelodysplastic syndrome (MDS).





- Brando B, Gatti A, Preijers F. Flow Cytometric Diagnosis of Paroxysmal Nocturnal Hemoglobinuria: Pearls and Pitfalls - A Critical Review Article. EJIFCC. 2019 Nov 25;30(4):355-370. PMID: 31814811; PMCID: PMC6893893. [Accesses 06 Nov. 2025]. Available From:
- Mishra P, Tripathi P, Halder R, Saxena R, Tyagi S, Mahapatra M, Pati HP. Clinico-Hematological Profile of Paroxysmal Nocturnal Hemoglobinuria in Indian Patients: FLAER Flow Cytometry Based Experience from an Indian Tertiary Care Centre. Indian J Hematol Blood Transfus. 2021 Apr;37(2):220-225. [Accesses 06 Nov. 2025]. Available From:
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