PLA2 Receptor antibody - Quantitative

The PLA2 Receptor antibody - Quantitative test is used to detect and measure antibodies against the M-type phospholipase A2 receptor (PLA2R), a protein found on specialized kidney cells called podocytes, which play a key role in filtering blood and preventing protein loss in urine. PLA2R is part of the phospholipase A2 (PLA2) family, a group of enzymes involved in breaking down certain fats (phospholipids) to produce molecules important for inflammation and cell signaling.

In a healthy body, PLA2R supports the normal function of kidney filters. However, in idiopathic membranous nephropathy (iMN), the immune system mistakenly produces antibodies that attack the PLA2R protein, damaging the kidney's filtering barrier and causing protein leakage into urine, known as proteinuria.

Doctors may recommend the PLA2 Receptor antibody - Quantitative test if signs of nephrotic syndrome are present, such as swelling in the legs, ankles, or around the eyes, foamy urine, weight gain, and low blood albumin levels. These are indicators that kidney function may be impaired.

The PLA2 Receptor antibody - Quantitative test helps in the early and accurate diagnosis of iMN, and can distinguish it from secondary membranous nephropathy, which can occur due to infections, autoimmune diseases like lupus, or cancer. It also helps in monitoring disease activity and evaluating response to treatment, especially immunosuppressive therapy.

No special preparation is required for the PLA2 Receptor antibody - Quantitative test. Inform the doctor about all medications or supplements currently being taken, as some of them may affect the test results, potentially requiring dosage adjustments or temporary discontinuation before the test.

Test result ranges are approximate and may differ slightly between labs depending on the methodology and laboratory guidelines. Do not self-medicate, and always consult a doctor to understand the test results correctly.

Please note: This is an outsourced test. The sample for this test is collected by TATA 1MG and processed at a NABL accredited partnered lab.