
Protein/Creatinine Ratio










The Protein/Creatinine Ratio test helps calculate the amount of protein relative to creatinine in a urine sample. It helps screen, assess, and monitor kidney function. It helps in the diagnosis of kidney damage or diseases, among several other conditions that can affect kidney health.













Understanding Protein/Creatinine Ratio
The Protein/Creatinine Ratio test is used to evaluate kidney health by determining the levels of protein excreted in urine relative to creatinine, a waste product generated by muscle metabolism. While there are often no signs and symptoms of early kidney damage, increasing amounts of protein in the urine can be an indicator.
The Protein/Creatinine Ratio test is a key indicator of kidney dysfunction and helps detect conditions such as proteinuria (an excess of protein in the urine). This condition can signal various kidney diseases, including glomerulonephritis (inflammation of the filtering part of the kidneys), diabetic nephropathy (a kidney disease caused by diabetes), and renal hypertension (high blood pressure caused by problems with the kidneys).
Consider getting tested if you are pregnant with a high risk of preeclampsia (a pregnancy complication characterized by high blood pressure), are taking medications that may impact the kidneys, or if a child has high urine protein levels. The Protein/Creatinine Ratio test is frequently done as a screening test whenever a urinalysis is performed, which may be part of a routine physical, a pregnancy workup, an evaluation for a urinary tract infection, a hospital admission, or any situation where a doctor wants to assess the kidney function.
A random mid-stream (part of urine that comes after the first and before the last stream) urine sample is usually collected for this test. However, it is essential to ensure that the urine sample is collected properly, avoiding any contamination. Ask your doctor about any specific dietary restrictions or test timings, if applicable, before undertaking the Protein/Creatinine Ratio test. Inform your doctor about all the medications or supplements that you are taking as these may affect the test results.
Lab test results may vary across laboratories. Do not self-medicate at home solely based on these results and always consult the doctor for proper understanding of the test results. By comparing protein/ creatinine ratio doctors can monitor kidney function, track disease progression, and assess the treatment effectiveness.
What does Protein/Creatinine Ratio measure?
The Protein/Creatinine Ratio test measures the amount of protein in the urine relative to the amount of creatinine, a waste product also found in the urine. This test is commonly done to assess kidney function and to detect kidney damage or disease. Normally, only a small amount of protein is present in the urine, but if the kidneys are impaired, they may allow more protein to pass through into the urine. By comparing the level of protein to creatinine, the Protein/Creatinine Ratio test provides a more nuanced assessment of how much protein is being excreted by the kidneys. Elevated levels of protein in the urine (proteinuria), can indicate various kidney conditions such as glomerulonephritis, diabetic nephropathy, renal hypertension etc. Monitoring the protein/ creatinine ratio helps doctors diagnose and manage these conditions, as well as assess the treatment response over time.





FAQs related to Protein/Creatinine Ratio
- Kamińska J, Dymicka-Piekarska V, Tomaszewska J, Matowicka-Karna J, Koper-Lenkiewicz OM. Diagnostic utility of protein to creatinine ratio (P/C ratio) in spot urine sample within routine clinical practice. Crit Rev Clin Lab Sci. 2020 Aug;57(5):345-364. [Accessed 03 Jun. 2024]. Available from:
- Haider MZ, Aslam A. Proteinuria. [Updated 2023 Sep 4]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from:
- Evans TRJ, Kudo M, Finn RS, Han KH, Cheng AL, Ikeda M, Kraljevic S, Ren M, Dutcus CE, Piscaglia F, Sung MW. Urine protein:creatinine ratio vs 24-hour urine protein for proteinuria management: analysis from the phase 3 REFLECT study of lenvatinib vs sorafenib in hepatocellular carcinoma. Br J Cancer. 2019 Jul;121(3):218-221. doi: 10.1038/s41416-019-0506-6. Epub 2019 Jun 28. Erratum in: Br J Cancer. 2019 Oct;121(7):625. [Accessed 03 Jun. 2024]. Available from:
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- LFT (Liver Function Test)
- KFT (Kidney Function Test)
- TSH (Thyroid Stimulating Hormone) Ultrasensitive
- ESR (Erythrocyte Sedimentation Rate)
- Uric Acid, Serum
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- Serum Electrolytes
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- Diabetes Screening (HbA1C & Fasting Sugar)
- KFT with Electrolytes (Kidney Function Test with Electrolytes)
- Cholesterol - Total
- Hb (Hemoglobin)
- Complete Hemogram (CBC & ESR)





















