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PR3 (c-ANCA)

PR3 (c-ANCA)

Also referred as
c-ANCA
SERIN PROTEINASE 3 ANTIBODIES
Proteinase 3
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The PR3 (c-ANCA) test is a blood test that helps diagnose certain autoimmune diseases, such as granulomatosis with polyangiitis (GPA), previously called Wegener's granulomatosis, and other forms of vasculitis (inflammation of blood vessels). It helps measure the antibodies against a specific protein called proteinase 3 (PR3), which is found in neutrophils (a type of white blood cell) that help fight off infections. It facilitates the prompt detection of these diseases and helps prevent organ damage by enabling timely treatment.

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Understanding PR3 (c-ANCA)

PR3 antibodies are formed when the immune system mistakenly attacks the PR3 enzyme, found inside neutrophils. These antibodies are also called c-ANCA (cytoplasmic antineutrophil cytoplasmic antibodies) due to their staining pattern (diffuse, granular appearance of cytoplasm) during lab tests.

The PR3 (c-ANCA) test helps diagnose autoimmune diseases such as GPA and other forms of vasculitis, monitor disease activity, guide treatment decisions, and rule out other conditions that can cause similar symptoms, such as infections or other autoimmune diseases.

A doctor may advise a PR3 (c-ANCA) test when there are symptoms of autoimmune vasculitis. General symptoms may include fever, fatigue, headache, weight loss, aches and pains, etc. Other symptoms depend on the parts of the body affected.

No special preparation is required for the PR3 (c-ANCA) test. Inform a doctor about all the medications (e.g., immunosuppressants, steroids, etc.) and supplements (e.g., biotin, etc.) that are currently being taken, as some of them may affect the test results, potentially requiring dosage adjustments or temporary discontinuation before the test.

Test result ranges are approximate and may differ slightly between labs depending on the methodology and laboratory guidelines. Do not self-medicate, and always consult a doctor to understand the test results correctly.

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What does PR3 (c-ANCA) measure?

The PR3 (c-ANCA) is a blood test that measures the levels of autoantibodies targeting the proteinase 3 (PR3) enzyme (located inside neutrophils). These autoantibodies are associated with autoimmune vasculitis disorders, particularly granulomatosis with polyangiitis (GPA), and other forms of vasculitis, where the immune system mistakenly attacks small blood vessels. This test helps diagnose these diseases, track disease activity, evaluate treatment response, and predict flare-ups.

Active inflammation is usually suggested by high PR3-ANCA levels, whereas a decline in their levels can indicate the effectiveness of treatment. Results should, however, be interpreted in conjunction with clinical symptoms, as not all individuals with these diseases are positive, and false positive results may occur with other conditions such as infections.

FAQs related to PR3 (c-ANCA)

The PR3 (c-ANCA) test detects autoantibodies targeting the PR3 enzyme in neutrophils. It helps diagnose and monitor autoimmune vasculitis disorders, particularly granulomatosis with polyangiitis (GPA).
No special preparation is required for this test.
The test is done by taking a blood sample from a vein in your arm. The sample is then analyzed for the levels of PR3 (c-ANCA) in the lab.
No, the PR3 (c-ANCA) test is generally safe with minimal risks. You may feel slight discomfort, bruising, or swelling at the blood draw site, which resolves on its own and is not bothersome.
A: Positive result: Indicates GPA or related vasculitis, but warrants further testing for confirmation. B: Negative result: Makes autoimmune vasculitis less likely, but does not rule it out entirely (some patients test negative). C: Fluctuating levels: May indicate a flare-up, while decreasing levels often reflect treatment success.
Yes, conditions such as infections (e.g., endocarditis, tuberculosis) or other autoimmune diseases (e.g., lupus) can cause false-positive results. Also, certain medications ( e.g., hydralazine) can trigger ANCA antibodies. Always consult a doctor to understand the test results correctly.
Tata 1mg ensures accurate lab test results through certified laboratories that use advanced technology and adhere to stringent quality control measures. This commitment to high standards guarantees reliable results.
Content created by
Written by:
Dr. Lipika Khurana
PGDHHM, BDS
Reviewed by:
Dr. Swati Gupta (Anand)
MBBS, MD Lab Medicine
Want to know moreRead our editorial policy
Last Updated23rd Nov 2025

PR3 (c-ANCA) test price for other cities

Price inNew DelhiRs. 1329
Price inGurgaonRs. 1329
Price inBangaloreRs. 1629
Price inHyderabadRs. 1900
Price inPuneRs. 1709

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Contains 1 test
PR3 (c-ANCA)