
MPN Panel 3







The MPN Panel 3 is a genetic test that detects vital mutations associated with myeloproliferative neoplasms (MPNs), a type of blood cancer. It helps doctors diagnose and classify MPNs, plan treatment, and monitor disease progression.









Understanding MPN Panel 3
Chronic myeloproliferative neoplasms (MPNs) are blood disorders in which the bone marrow produces too many red blood cells, white blood cells, or platelets. The {tet_name} is a comprehensive blood test used to evaluate genetic changes in blood cells that are characteristic of MPNs.
The MPN Panel Advanced detects key genetic mutations and fusions, including CALR, JAK2 (exons 12–15), MPL, and the BCR-ABL fusion. This helps doctors identify and classify different types of myeloproliferative neoplasms (MPNs), including both BCR-ABL1–positive and BCR-ABL1–negative conditions such as chronic myeloid leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF).
Doctors may recommend this panel if you experience symptoms such as fatigue, weakness, night sweats, or an enlarged spleen, or if you have abnormal blood counts. It is also advised for individuals with a family history of MPNs or known genetic risk factors. This test helps diagnose specific MPNs, differentiate between subtypes for appropriate treatment, monitor therapy response, and assess complication risks.
For this test, it is important to submit the clinical history, histopathology report, previous test results, and a doctor’s prescription at the time of sample collection. The Tata 1mg consolidated Test Requisition Form (TRF) must also be duly filled and submitted.
Lab test results may vary across different laboratories. Abnormal test results require an expert interpretation. Therefore, never try to self-medicate at home based solely on these results, and always consult a doctor for proper understanding of the test results.
What does MPN Panel 3 measure?
Contains 4 testsThe MPN Panel 3 detects important genetic mutations and gene fusions that help diagnose and classify myeloproliferative neoplasms (MPNs). This includes CALR mutations, JAK2 mutations (exons 12–15), MPL mutations, and the BCR-ABL1 fusion, which is essential for identifying chronic myeloid leukemia (CML). By analyzing these mutations and fusions, the test provides a comprehensive genetic profile, enabling doctors to accurately diagnose, classify, and manage both BCR-ABL1–positive and BCR-ABL1–negative MPNs.
Abnormal results may indicate the presence of specific MPNs: BCR-ABL1 fusion may suggest CML, JAK2 mutations may indicate polycythemia vera (PV) or essential thrombocythemia (ET), and CALR or MPL mutations may point to primary myelofibrosis (PMF). Further evaluation and consultation with a hematologist are necessary for accurate diagnosis and appropriate treatment.
The BCR-ABL Qualitative PCR test checks a blood or bone marrow sample for the presence or absence of BCR-ABL mRNA transcripts, which are produced due to a chromosomal change called t(9;22), also known as the Philadelphia chromosome. If the test is positive, it can identify the specific transcript type, such as p210 (e13a2/e14a2) or p190 (e1a2), which helps doctors understand the type of leukemia and plan treatment accordingly.
Know more about BCR-ABL Qualitative PCR





FAQs related to MPN Panel 3
- Fowlkes S, Murray C, Fulford A, De Gelder T, Siddiq N. Myeloproliferative neoplasms (MPNs) - Part 1: An overview of the diagnosis and treatment of the "classical" MPNs. Can Oncol Nurs J. 2018 Oct 1;28(4):262-268. [Accessed 14 Oct. 2025]. Available from:
- Rapado I, Grande S, Albizua E, Ayala R, Hernández JA, Gallardo M, Gilsanz F, Martinez-Lopez J. High resolution melting analysis for JAK2 Exon 14 and Exon 12 mutations: a diagnostic tool for myeloproliferative neoplasms. J Mol Diagn. 2009 Mar;11(2):155-61. [Accessed 14 Oct. 2025]. Available from:
- Thapa B, Fazal S, Parsi M, et al. Myeloproliferative Neoplasms. [Updated 2023 Aug 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from:
- Stock W, Yu D, Karrison T, Sher D, Stone RM, Larson RA, Bloomfield CD. Quantitative real-time RT-PCR monitoring of BCR-ABL in chronic myelogenous leukemia shows lack of agreement in blood and bone marrow samples. Int J Oncol. 2006 May;28(5):1099-103. PMID: 16596225. [Accessed 14 Oct. 2025]. Available From:
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