
Mean Corpuscular Hemoglobin Concentration (MCHC)









The Mean Corpuscular Hemoglobin Concentration (MCHC) test helps measure the concentration of hemoglobin in the red blood cells (RBCs). This test is a key indicator to check for signs of anemia and other blood disorders. It is often done as part of a complete blood count test that also measures other types of blood cells.













Understanding Mean Corpuscular Hemoglobin Concentration (MCHC)
Hemoglobin is an iron-containing protein that helps carry oxygen in your body. By measuring the amount of hemoglobin in your RBCs, the MCHC test can help diagnose several medical conditions, including iron deficiency anemia, macrocytic anemia, hemolytic anemia, thalassemia, etc. This test provides information on how effectively oxygen is being distributed throughout your body.
Low levels of MCHC may indicate anemia like iron deficiency anemia, thalassemia etc or another condition that affects your red blood cells. Whereas, high levels of MCHC indicate a high concentration of hemoglobin within your RBCs. It can occur in conditions where RBCs are fragile or destroyed, or when RBCs get agglutinated (clumping of RBCs). No special preparation is required for an MCHC test; eat or drink as per your daily routine.
Test result ranges are approximate and may differ slightly between different labs depending on the methodology and laboratory guidelines. Talk to your doctor about your specific test results. The results will help them determine your medical condition and formulate your overall treatment plan.
What does Mean Corpuscular Hemoglobin Concentration (MCHC) measure?
The MCHC test measures the average amount of hemoglobin in a given volume of RBCs. MCHC is calculated by dividing the amount of hemoglobin by hematocrit (volume of blood made up of RBCs) and then multiplying it by 100.





FAQs related to Mean Corpuscular Hemoglobin Concentration (MCHC)
- Sato K, Inoue S, Ishibashi Y, Ota T, Murano H, Furuyama K, Yang S, Machida H, Nakano H, Sato M, Nemoto T, Nishiwaki M, Yamauchi K, Igarashi A, Watanabe M. Association between low mean corpuscular hemoglobin and prognosis in patients with exacerbation of chronic obstructive pulmonary disease. Respir Investig. 2021;59(4):498-504. [Accessed 29 Aug. 2024]. Available from:
- Constantino BT, Cogionis B. High Mean Corpuscular Hemoglobin Concentration: Its Causes and Effects on Automated CBC Results. Can J Med Lab Sci. 2007;69(3):113-126. [Accessed 29 Aug. 2024]. Available from:
- Lokwani DP. The ABC of CBC: Interpretation of Complete Blood Count & Histograms. 1st ed. Jaypee Brothers Medical Publishers; 2013.
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