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Understanding the Test
Test Measures
Interpreting Results
FAQ's
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References
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Dr. Shreya Gupta
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hsCRP (High Sensitive CRP)

Also known as High Sensitivity C-Reactive Protein
609800 23% Off
You need to provide
Blood
This test is for
Male, Female
Test Preparation
  1. Overnight fasting is preferred.

Understanding hsCRP (High Sensitive CRP)


What is hsCRP (High Sensitive CRP)?

An hsCRP (High Sensitive CRP) test measures even a slight increase in CRP (C-reactive protein) levels. This sensitive test helps evaluate the risk of cardiovascular disease (CVD) in an individual. It derives its name from its greater sensitivity to CRP levels, even within the normal range. CRP levels increase in the blood with inflammation, infection as well as after a heart attack, surgery, or trauma. 

High-sensitive C-reactive protein (hsCRP) predicts the risk of myocardial infarction (heart attack), stroke, peripheral artery disease, and sudden cardiac death in healthy people without a history of any heart-related issues. Since an hsCRP (High Sensitive CRP) test detects minor elevations in the normal range of CRP, it is a more specific variation of the standard CRP test. In easy terms, the higher the hsCRP, the higher the risk of cardiovascular diseases. 

An hsCRP (High Sensitive CRP) test may be used in combination with other tests like a lipid profile or other cardiac risk markers, such as lipoprotein-associated phospholipase A2 (Lp-PLA2) test, to determine the additional risk of developing heart disease. Moreover, this test is also used in the diagnosis of heart attacks to know whether an individual is at risk of experiencing it again. Depending upon your lipid levels and previous history or family history of heart attack, an hsCRP test can be advised.

Usually, overnight fasting (8-12 hours) is preferred for this test. Do not eat or drink anything, except water, before the test. Your doctor will also look at your results based on your age, diet, cholesterol levels, blood pressure, and other factors. Narrate your complete medical history to help them correlate your clinical and laboratory findings. The results will help the doctor determine your medical condition, make recommendations such as lifestyle modifications including diet, exercise, etc., to manage your overall health, and formulate your treatment plan. 

What is hsCRP (High Sensitive CRP) used for?

An hsCRP (High Sensitive CRP) test is done to:

  • Evaluate your risk of cardiovascular disease or stroke.  

  • Check for bacterial or viral infections if you have symptoms such as fever, chills, redness, swelling, nausea, vomiting, rapid breathing, and/or rapid heart rate.

  • Detect and monitor the flare-ups of autoimmune diseases, like rheumatoid arthritis, lupus, inflammatory bowel disease (IBD), etc.

  • Assess the treatment efficacy of chronic inflammatory conditions.

  • Check for sepsis, a serious life-threatening medical emergency resulting from the body's extreme response to an infection.

What does hsCRP (High Sensitive CRP) measure?

An hsCRP (High Sensitive CRP) test is a state-of-the-art biochemical marker to predict potential risks of future diseases. This test is more sensitive than the standard CRP test and can detect lower levels of the protein. Its accuracy in predicting cardiovascular issues, autoimmune disorders, and other health issues makes it an excellent test to detect asymptomatic conditions with limited diagnosis.

Interpreting hsCRP (High Sensitive CRP) results


Interpretations

A desirable blood level of Hs-CRP is less than 1 mg/ml.

Low risk: less than 1.0 mg/L

Average risk: 1.0 to 3.0 mg/L

High risk: above 3.0 mg/L

Above 10 mg/mL: indicates acute inflammation

Answers to Patient Concerns & Frequently Asked Questions (FAQs) about hsCRP (High Sensitive CRP)


Frequently Asked Questions about hsCRP (High Sensitive CRP)

Q. What does high levels of hsCRP mean?

An hsCRP (High Sensitive CRP) test is a CVD risk screening test; Hence, the high levels of hsCRP indicate the increased risk of developing heart disease and its complications such as heart attacks, strokes, peripheral vascular disease, and sudden cardiac death.

Q. What are the risk factors for cardiovascular diseases?

Age, gender, and a family history of early heart disease are some of the risk factors for cardiovascular disease that cannot be controlled. However, there are some other risk factors including high blood pressure, high cholesterol, obesity, or diabetes that can be controlled to reduce the risk of cardiovascular disease.

Q. What can be the possible causes for high hsCRP levels?

One major cause of high hsCRP levels is obesity. Adipose or fat tissue produces cytokines that cause inflammation throughout the body. Conditions such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) or other autoimmune conditions, infections like pancreatitis or bronchitis, acute/chronic bacterial and viral infections, or major trauma can cause high hsCRP levels.

Q. What is the difference between a CRP test and an hsCRP test?

A standard CRP test measures markedly high levels of CRP to detect diseases that cause significant inflammation. However, the high-sensitivity CRP test detects even lower levels of CRP than the standard CRP test and therefore helps in evaluating an individual’s risk of developing cardiovascular disease (CVD) or similar conditions.

Q. Is the hsCRP specific for predicting heart diseases?

No, the hsCRP is not specific for predicting heart disease. It is a marker of inflammation and can increase in various other medical conditions such as chronic inflammatory conditions (rheumatological disease, lupus, vasculitis), inflammatory bowel disease, infections (such as pneumonia, tuberculosis), surgery, drug reaction, burns, oral contraceptive pill use, or trauma. Recent studies have shown that having CRP in the high range may also be associated with other diseases such as colon cancer, complications of diabetes, and obesity.

Q. What additional tests can be prescribed by the doctor in case the result of an hsCRP test is not normal?

Additional tests that may be prescribed in case your hsCRP test shows abnormal results are the erythrocyte sedimentation rate (ESR), rheumatoid factor (RF) test, and anti-cyclic citrullinated peptide (anti-CCP) antibody test.

Q. What are chronic inflammatory diseases?

Chronic inflammatory diseases are conditions that lead to the development of long-lasting or frequently recurring inflammation, such as rheumatoid arthritis, lupus, and inflammatory bowel disease.

Q. How can I naturally reduce my hsCRP levels?

Always consult your doctor if your hsCRP levels are high. However, some lifestyle modifications such as making healthy food choices, adding fiber and vitamin-rich foods to your daily diet, exercising regularly to maintain a healthy body weight, limiting alcohol intake and smoking, and managing stress may help you reduce your CRP levels naturally.
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hsCRP (High Sensitive CRP) test price for other cities


Price inMumbaiRs. 409
Price inBangaloreRs. 609
Price inGurgaonRs. 609
Price inPuneRs. 409
Price inKolkataRs. 609
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References

  1. Kamath DY, Xavier D, Sigamani A, Pais P. High sensitivity C-reactive protein (hsCRP) & cardiovascular disease: An Indian perspective. Indian J Med Res. 2015 Sep;142(3):261-8. [Accessed 25 Sept. 2023]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669860/ External Link
  2. Understanding your risk for heart disease. Internet]. NIH; 24 Mar. 2022. [Accessed 25 Sept. 2023]. Available from: https://www.nhlbi.nih.gov/health/heart-healthy-living/risks External Link
  3. Yousuf O, Mohanty BD, Martin SS, Joshi PH, Blaha MJ, Nasir K, Blumenthal RS, Budoff MJ. High-sensitivity C-reactive protein and cardiovascular disease: a resolute belief or an elusive link? J Am Coll Cardiol. 2013 Jul 30;62(5):397-408. [Accessed 25 Sept. 2023]. Available from: https://pubmed.ncbi.nlm.nih.gov/23727085/ External Link
  4. Banait T, Wanjari A, Danade V, Banait S, Jain J. Role of High-Sensitivity C-reactive Protein (hs-CRP) in Non-communicable Diseases: A Review. Cureus. 2022 Oct 12;14(10):e30225. [Accessed 25 Sept. 2023]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650935/ External Link
  5. Ridker PM. Inflammation, high-sensitivity C-reactive protein, and vascular protection. Tex Heart Inst J. 2010;37(1):40-1. [Accessed 25 Sept. 2023]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829802/ External Link
  6. Bassuk SS, Rifai N, Ridker PM. High-sensitivity C-reactive protein: clinical importance. Curr Probl Cardiol. 2004 Aug;29(8):439-93. [Accessed 25 Sept. 2023]. Available from: https://pubmed.ncbi.nlm.nih.gov/15258556/#:~:text=High%2Dsensitivity%20C%2Dreactive%20protein%20(hsCRP)%20is%20a,patients%20with%20acute%20or%20stable External Link
  7. C-Reactive Protein (Blood) [Internet]. Rochester, NY: University of Rochester Medical Center; [Accessed 25 Sept. 2023]. Available from: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=c_reactive_protein_serumExternal Link

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