Factor V Leiden Mutant Detection (G1691A Mutation)

Also referred as

Factor V Leiden Mutation Test

G1691A Mutation Test

Factor V R506Q Mutation Test

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The Factor V Leiden Mutant Detection (G1691A Mutation) test is a blood test that identifies the presence of a specific genetic mutation called factor V Leiden. This mutation can increase the risk of abnormal blood clot formation, helping doctors evaluate the likelihood of venous thrombosis and related conditions.

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Understanding Factor V Leiden Mutant Detection (G1691A Mutation)

Factor V is a protein that plays a central role in blood clotting. Normally, activated protein C regulates clot formation by inactivating factor V to prevent excessive clotting. However, a mutation in the factor V Leiden gene (G1691A) makes the factor V protein resistant to being inactivated, which can lead to a higher risk of developing abnormal blood clots, such as deep vein thrombosis (DVT) or venous thromboembolism (VTE).

Identifying the presence of the Factor V Leiden mutation is important because it helps explain why some individuals are more prone to abnormal clotting.

The Factor V Leiden Mutant Detection (G1691A Mutation) test is especially useful for individuals with unexplained or recurrent episodes of blood clots, including deep vein thrombosis (DVT) or venous thromboembolism (VTE). It is recommended for patients with a personal or family history of the factor V Leiden mutation or those with a family background of blood-clotting disorders. Women experiencing recurrent miscarriages or pregnancy complications linked to abnormal clotting may also benefit from this test, as the mutation can contribute to pregnancy loss. In addition, it is valuable in cases of clinically suspected thrombophilia, where an inherited gene mutation may increase the risk of abnormal clot formation. By identifying whether a person carries the factor V Leiden mutation, doctors can assess the risk of thrombosis and guide appropriate preventive measures and treatment strategies.

No special preparation is needed for getting the Factor V Leiden Mutant Detection (G1691A Mutation) test done. However, it is preferred that you share your clinical history, current medications, and supplement use with your doctor before giving the sample, as these may influence the results.

Test result ranges are approximate and may differ slightly between labs depending on the methodology and laboratory guidelines. Do not self-medicate, and always consult a doctor to understand the test results correctly.

Please note: This is an outsourced test. The sample for this test is collected by TATA 1MG and processed at a NABL accredited partnered lab.

What does Factor V Leiden Mutant Detection (G1691A Mutation) measure?

The Factor V Leiden Mutant Detection (G1691A Mutation) test determines whether a person carries the specific genetic change in the factor V gene known as the G1691A mutation. This mutation alters the way factor V functions by making it resistant to inactivation by activated protein C (APC), a natural regulator that normally helps control clot formation. When factor V cannot be properly switched off, the balance between clot formation and breakdown is disrupted, leading to an increased tendency for abnormal blood clots to develop in the veins.

By detecting the presence or absence of this mutation, the test helps doctors determine an individual’s inherited risk of venous thrombosis, including deep vein thrombosis (DVT) and venous thromboembolism (VTE). It also provides useful information for patients with a family history of clotting disorders or those with unexplained episodes of thrombosis. Identifying this genetic risk factor allows healthcare providers to recommend preventive measures, lifestyle modifications, or medical treatment to reduce the likelihood of future clot-related complications.

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Test Information is reviewed by: Dr. Swati Gupta (Anand), MBBS, MD Lab Medicine and written by Dr. Lipika Khurana, PGDHHM, BDS . The test details are for information purpose only. Consult a doctor before taking any test. Last updated on: 18th Sep 2026

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Factor V Leiden Mutant Detection (G1691A Mutation) test price for other cities

Price in	Mumbai	Rs. 5539
Price in	Bangalore	Rs. 5849
Price in	New Delhi	Rs. 6600
Price in	Thane	Rs. 5539
Price in	Kolkata	Rs. 5309

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FAQs related to Factor V Leiden Mutant Detection (G1691A Mutation)

What is the Factor V Leiden Mutant Detection (G1691A Mutation) test?

It is a blood test that looks for a specific genetic mutation (G1691A) in the factor V gene, which increases the risk of abnormal blood clots.

Why is this test done?

The test is done to check if you have inherited the factor V Leiden mutation, which can make you more likely to develop conditions like deep vein thrombosis (DVT) or venous thromboembolism (VTE).

Who should get this test done?

This test is advised if you have unexplained blood clots, a family history of clotting disorders, recurrent miscarriages, or if your doctor suspects thrombophilia.

How is the test performed?

A small blood sample is taken from a vein and analyzed in the lab using real-time PCR technology to detect the mutation.

Do I need to fast before this test?

No, fasting is not required for this test.

What does a positive test result mean?

A positive result means the factor V Leiden mutation is present, which increases your risk of developing blood clots.

Can I have the mutation without any symptoms?

Yes, some people carry the mutation but may never develop clots. However, their risk is higher compared to people without the mutation.

What does a negative test result mean?

A negative result means you do not carry the factor V Leiden mutation, and your risk of inherited thrombophilia from this mutation is low.

Is the factor V Leiden mutation inherited?

Yes, the factor V Leiden mutation is passed from parents to children. You can inherit one or two copies of the mutated gene.

What is the difference between having one copy or two copies of the mutation?

Having one copy (heterozygous) increases your risk moderately, while having two copies (homozygous) increases your risk of clotting much more.

Can this test help with pregnancy complications?

Yes, it is useful in cases of recurrent miscarriages or pregnancy problems linked to abnormal clotting.

Can this mutation be treated or cured?

The mutation itself cannot be cured, but its risks can be managed with proper medical care and preventive measures.

How does Tata 1mg ensure accurate lab test results?

Tata 1mg ensures accurate lab test results through certified laboratories that use advanced technology and adhere to stringent quality control measures. This commitment to high standards guarantees reliable results.

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