
DPD/DPYD Mutation Analysis near me in Pune







The DPD/DPYD Mutation Analysis test detects mutations in the DPYD gene, which provides instructions for making the enzyme Dihydropyrimidine Dehydrogenase (DPD). This enzyme is essential for breaking down certain chemotherapy medicines like 5-Fluorouracil (5-FU) and Capecitabine. The test helps identify individuals who may have DPD deficiency, a condition that can cause severe or even life-threatening side effects when treated with standard doses of these medicines. Early detection allows doctors to adjust chemotherapy doses or choose alternative treatments for safer and more effective care. This test is widely available with Tata 1mg labs at an affordable price in Pune.








What does DPD/DPYD Mutation Analysis measure?
The DPD/DPYD Mutation Analysis test examines the DPYD gene for mutations that affect the production or function of the Dihydropyrimidine Dehydrogenase (DPD) enzyme.
This enzyme is crucial for metabolizing chemotherapy medicines like 5-Fluorouracil and Capecitabine. When DPD activity is reduced or absent, the body cannot properly break down these medicines, leading to an increased risk of severe toxicity.
Normal result indicates no significant mutation and normal DPD enzyme activity, standard chemotherapy dosing is generally safe. Abnormal results suggest reduced or absent DPD enzyme activity. Dosage adjustment or an alternate chemotherapy regimen may be recommended.
By identifying these mutations, the test helps doctors tailor chemotherapy safely, minimizing side effects and improving treatment outcomes.





- Patil VM, Noronha V, Joshi A, Zanwar S, Ramaswamy A, Arya S, Mahajan A, Bhattacharjee A, Prabhash K. Dihydropyrimidine dehydrogenase mutation in neoadjuvant chemotherapy in head and neck cancers: Myth or reality? South Asian J Cancer. 2016 Oct-Dec;5(4):182-185.
- Cancer Research UK. DPD deficiency [Internet]. London: Cancer Research UK; updated 11 July 2023; [Accessed 04 Nov 2025]. Available from:
Other tests
- Comprehensive Gold Full Body Checkup with Smart Report in Pune
- Comprehensive Silver Full Body Checkup with Smart Report in Pune
- PPBS (Postprandial Blood Sugar) in Pune
- CBC (Complete Blood Count) in Pune
- HbA1c (Glycosylated Hemoglobin) in Pune
- FBS (Fasting Blood Sugar) in Pune
- Good Health Gold Package with Smart Report in Pune
- Urine R/M (Urine Routine & Microscopy) in Pune
- Thyroid Profile Total (T3, T4 & TSH) in Pune
- Lipid Profile in Pune
- Comprehensive Check-up in Pune
- CRP (C-Reactive Protein), Quantitative in Pune
- Vitamin B12 in Pune
- TW-EYGDS HC in Pune
- Magnesium in Pune
- Good Health Platinum Package with Smart Report in Pune
- Fever Package Advanced (includes Dengue, Malaria & Typhoid Tests) in Pune
- Senior Citizen Health Checkup with Smart Report in Pune
- Men Health Checkup Premium with Smart Report in Pune
- Men Health Checkup Advanced with Smart Report in Pune
- PT INR (Prothrombin Time with INR) in Pune
- Women Health Checkup Advanced with Smart Report in Pune
- HIV 1 and 2 Antibody, Rapid Screening Test in Pune
- Super Employee Health Check-up in Pune
- Vitamin D, B12 & Calcium in Pune
- CBC (Complete Blood Count)
- FBS (Fasting Blood Sugar)
- Thyroid Profile Total (T3, T4 & TSH)
- HbA1c (Glycosylated Hemoglobin)
- PPBS (Postprandial Blood Sugar)
- Lipid Profile
- Vitamin D (25-Hydroxy)
- Urine R/M (Urine Routine & Microscopy)
- Coronavirus Covid -19 test- RT PCR
- LFT (Liver Function Test)
- KFT (Kidney Function Test)
- TSH (Thyroid Stimulating Hormone) Ultrasensitive
- ESR (Erythrocyte Sedimentation Rate)
- Uric Acid, Serum
- Vitamin B12
- CRP (C-Reactive Protein), Quantitative
- Urine C/S (Urine Culture and Sensitivity)
- Serum Electrolytes
- Serum Calcium
- Serum Creatinine
- Diabetes Screening (HbA1C & Fasting Sugar)
- KFT with Electrolytes (Kidney Function Test with Electrolytes)
- Cholesterol - Total
- Hb (Hemoglobin)
- Complete Hemogram (CBC & ESR)















