DPD/DPYD Mutation Analysis near me in Bangalore

The DPD/DPYD Mutation Analysis test is a genetic test used to identify mutations in the DPYD gene, which codes for the Dihydropyrimidine Dehydrogenase (DPD) enzyme. This enzyme plays a vital role in breaking down and removing fluoropyrimidine-based chemotherapy medicines, such as 5-Fluorouracil (5-FU) and Capecitabine, from the body.

Some people are born with reduced or absent DPD enzyme activity due to inherited DPYD gene mutations. When such individuals receive standard doses of fluoropyrimidine chemotherapy, their bodies are unable to metabolize the medicine efficiently. This leads to toxic buildup and can cause severe side effects such as bone marrow suppression, mouth ulcers, diarrhea, neurotoxicity, and, in extreme cases, life-threatening complications.

Testing for DPYD gene mutations before starting chemotherapy helps doctors predict the patient’s ability to tolerate fluoropyrimidine medicines. Based on the test results, the chemotherapy dosage can be adjusted, or an alternative medicine can be selected to prevent toxicity while maintaining treatment effectiveness.

Doctors may recommend this test for individuals who are:

• About to begin treatment with 5-FU or Capecitabine
• Experiencing unexpected severe side effects after starting fluoropyrimidine-based chemotherapy
• Having a family history of DPD deficiency or treatment-related toxicity

For this test, it is important to submit the clinical history, histopathology report, previous test results, and a doctor’s prescription at the time of sample collection. The Tata 1mg consolidated Test Requisition Form (TRF) must also be duly filled and submitted.

Lab test results may vary across different laboratories. Abnormal test results require an expert interpretation. Therefore, never try to self-medicate at home based solely on these results, and always consult a doctor for a proper understanding of the test results.